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Inapplicable"},{"orgOrder":0,"company":"Akeso","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Cadonilimab","moa":"PD-1\/CTLA-4","graph1":"Oncology","graph2":"Phase III","graph3":"Akeso","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Akeso \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Akeso \/ Inapplicable"},{"orgOrder":0,"company":"Akeso","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CHINA","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Ivonescimab","moa":"||PD-1\/VEGF","graph1":"Oncology","graph2":"Phase III","graph3":"Akeso","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Akeso \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Akeso \/ Inapplicable"}]

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                          01

                          BioAsia
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                          BioAsia
                          Not Confirmed

                          Details : AK112 (ivonescimab) a PD-1/VEGF bispecific antibody is being developed in combination with chemotherapy as the first-line treatment of triple-negative breast cancer.

                          Product Name : AK112

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          February 20, 2025

                          Lead Product(s) : Ivonescimab,Gemcitabine,Cisplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          BioAsia
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                          BioAsia
                          Not Confirmed

                          Details : AK104 (cadonilimab), a novel bispecific antibody targets PD-1 and CTLA-4, which is currently being evaluated for the treatment of unresectable locally advanced non-small cell lung cancer.

                          Product Name : AK104

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          February 12, 2025

                          Lead Product(s) : Cadonilimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : AK111 (gumokimab) is an innovative, humanized IL-17 (interleukin-17) monoclonal antibody being developed for the treatment of autoimmune diseases such as psoriasis and ankylosing spondylitis.

                          Product Name : AK111

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 26, 2025

                          Lead Product(s) : Gumokimab

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : Under the terms of the agreement, Sichuan Kelun is reponsible for the development of KL-A167 (tagitanlimab), antibody targeting PD-L1, following its recent marketing approval by China's NMPA.

                          Product Name : KL-A167

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          January 22, 2025

                          Lead Product(s) : Tagitanlimab,Cisplatin,Gemcitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : Sichuan Kelun Pharmaceutical

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          05

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : AK105 (penpulimab) is a differentiated PD-1 monoclonal antibody, which is being evaluated in combination with Anlotinib HCl for the first-line (1L) treatment of advanced hepatocellular carcinoma.

                          Product Name : AK105

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 22, 2024

                          Lead Product(s) : Penpulimab,Anlotinib Hydrochloride

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : AK112 (ivonescimab) a PD-1/VEGF bispecific antibody is being developed in combination with gemcitabine & cisplatin as the first-line treatment of advanced biliary tract cancers.

                          Product Name : AK112

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 31, 2024

                          Lead Product(s) : Ivonescimab,Gemcitabine,Cisplatin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : PD-1/VEGF bispecific antibody ivonescimab in combination with CD47 monoclonal antibody ligufalimab (AK117) is being investigated for PD-L1 positive recurrent/metastatic HNSCC.

                          Product Name : AK112

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 30, 2024

                          Lead Product(s) : Ivonescimab,Ligufalimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : The proceeds will be used in accelerating the global clinical development of innovative drugs developed internally by Akeso, including AK-104 (cadonilimab) for first-line treatment of cervical cancer.

                          Product Name : AK104

                          Product Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 13, 2024

                          Lead Product(s) : Cadonilimab,Cisplatin,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $250.0 million

                          Deal Type : Private Placement

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                          09

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : Cadonilimab, a novel bispecific antibody targets PD-1 and CTLA-4 has been approved in combination with chemotherapy for locally advanced unresectable or metastatic G/GEJ adenocarcinoma.

                          Product Name : AK104

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 30, 2024

                          Lead Product(s) : Cadonilimab,Fluoropyrimidine,Capecitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          BioAsia
                          Not Confirmed
                          BioAsia
                          Not Confirmed

                          Details : AK112 (ivonescimab) is a novel, potential first-in-class investigational bispecific antibody inhibiting PD-1 with VEGF is being investiated for PD-L1-positive NSCLC.

                          Product Name : AK112

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 08, 2024

                          Lead Product(s) : Ivonescimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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