Alector Shares AL002 Phase 2 Data in Early Alzheimer’s Disease
Details : AL002 is a humanized monoclonal antibody that targets the triggering receptor expressed on myeloid cells 2 (TREM2). It was being investigated for early Alzheimer’s disease.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
November 26, 2024
Lead Product(s) : AL002
Therapeutic Area : Neurology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : AL002 is a patented method using a mutant-peptide sensitized cell as a cell-based therapeutic vaccine that reduces beta-amyloid plaque and seeks to restore the ability of the patient’s immunological system to combat Alzheimer’s disease.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
September 30, 2021
Lead Product(s) : AL002
Therapeutic Area : Neurology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : AL002
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : A five-dose GLP study with AL002-sensitized cells was completed using a transgenic (or genetically modified) mouse model of Alzheimer’s disease to investigate the tolerability of AL002.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
July 23, 2021
Lead Product(s) : AL002
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : AL002 is an investigational humanized monoclonal antibody that targets triggering receptor expressed on myeloid cells 2 (TREM2) with the most important genetic links to sporadic Alzheimer’s disease.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
January 25, 2021
Lead Product(s) : AL002
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Sanders-Brown Study Leads to Potential for a New Treatment Approach to Alzheimer’s Disease
Details : 5XFAD mice in the intracranial administration study were assigned to one of two injection groups: AL002a, a Trem2-agonizing antibody, or MOPC, an isotype-matched control antibody.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
August 25, 2020
Lead Product(s) : AL002
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Alector Announces Publication of Preclinical and Phase 1 Data Validating Potential of AL002
Details : AL002 was shown to be well-tolerated in a first-in-human Phase 1 SAD study in healthy volunteers and modulated cerebrospinal fluid biomarkers indicative of brain target engagement.
Product Name : AL002
Product Type : Antibody
Upfront Cash : Inapplicable
June 25, 2020