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    [{"orgOrder":0,"company":"Alcon Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Netarsudil Mesylate","moa":"Rho-associated protein kinase","graph1":"Ophthalmology","graph2":"Approved","graph3":"Alcon Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Ophthalmic Solution","sponsorNew":"Alcon Inc \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Alcon Inc \/ Not Applicable"},{"orgOrder":0,"company":"Alcon Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Dexamethasone","moa":"Glucocorticoid receptor","graph1":"Ophthalmology","graph2":"Phase II","graph3":"Alcon 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Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Alcon Inc \/ Ocumension Therapeutics","highestDevelopmentStatusID":"12","companyTruncated":"Alcon Inc \/ Ocumension Therapeutics"}]

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                            01

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : HYDROXYPROPYLMETHYLCELLULOSE,Glycerine,Dextrans

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : OcuMension Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            OcuMension Acquires Alcon Eye Drops with 16.7% Equity, Strategic Partnership Begins

                            Details : OcuMension will acquire outright, Tears Natural Forte, Bion Tears, Alcaine, Fluorescite, and Cyclogyl, in the Chinese market and AR-15512, a novel topical drug candidate for dry eye.

                            Brand Name : Tears Naturale Forte

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 12, 2024

                            Lead Product(s) : HYDROXYPROPYLMETHYLCELLULOSE,Glycerine,Dextrans

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : OcuMension Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            02

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon Completes Acquisition of Aerie Pharmaceuticals, Inc., Strengthening Company’s Ophthalmic Pharmaceutica...

                            Details : Alcon will add Rocklatan (netarsudil and latanoprost ophthalmic solution) and Rhopressa (netarsudil ophthalmic solution), as well as AR-15512, a Phase 3 candidate for dry eye disease, and a pipeline of several clinical and preclinical ophthalmic pharmace...

                            Brand Name : Rocklatan

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

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                            03

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon Completes Acquisition of Aerie Pharmaceuticals, Inc., Strengthening Company’s Ophthalmic Pharmaceutica...

                            Details : Through the transaction, Alcon has added the commercial products Rocklatan (netarsudil and latanoprost ophthalmic solution) 0.02%/0.005% and Rhopressa (netarsudil ophthalmic solution) 0.02%, as well as AR-15512, a Phase 3 product candidate for dry eye di...

                            Brand Name : Rocklatan

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            November 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Alcon Inc

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            04

                            Alcon Inc

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                            Antibody Engineering
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                            Alcon Inc

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                            Antibody Engineering
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                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon to Acquire Aerie Pharmaceuticals, Inc., Enhancing its Ophthalmic Pharmaceutical Portfolio

                            Details : Alcon will add Rocklatan (netarsudil and latanoprost ophthalmic solution) and Rhopressa (netarsudil ophthalmic solution), as well as AR-15512, a Phase 3 candidate for dry eye disease, and a pipeline of several clinical and preclinical ophthalmic pharmace...

                            Brand Name : Rocklatan

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 22, 2022

                            Lead Product(s) : Netarsudil,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Alcon Inc

                            Deal Size : $930.0 million

                            Deal Type : Acquisition

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                            05

                            Alcon Inc

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                            Antibody Engineering
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                            Alcon Inc

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                            Antibody Engineering
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                            Lead Product(s) : AVX012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerie Pharmaceuticals Announces First Participant Dosed in the COMET-3 Study of AR-15512 for the Treatment of ...

                            Details : AR-15512 is a first-in-class TRPM8 agonist which acts as a cold thermoreceptor modulator to stimulate the cold sensing receptors found on the nerve endings that innervate the cornea and eyelids.

                            Brand Name : AR-15512

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 01, 2022

                            Lead Product(s) : AVX012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Alcon Inc

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                            Lead Product(s) : AVX012

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerie Pharmaceuticals Announces First Participant Dosed in the Phase 3 Registrational COMET-2 Study of AR-1551...

                            Details : AR-15512 (AVX012), is a first-in-class TRPM8 agonist which acts as a cold thermoreceptor modulator to stimulate the cold sensing receptors found on the nerve endings that innervate the cornea and eyelids.

                            Brand Name : AR-15512

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 24, 2022

                            Lead Product(s) : AVX012

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Alcon Inc

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                            Antibody Engineering
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                            Alcon Inc

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                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Recipient : Kala Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Alcon to Acquire EYSUVIS Adding to Its Ophthalmic Eye Drop Portfolio

                            Details : The acquisition will complement Alcon’s existing portfolio in the large and fast-growing dry eye category. EYSUVIS (Loteprednol Etabonate) will complement the Systane® family of eye drops which includes the recently launched Systane Preservative-Free ...

                            Brand Name : Eysuvis

                            Molecule Type : Small molecule

                            Upfront Cash : $60.0 million

                            May 23, 2022

                            Lead Product(s) : Loteprednol Etabonate

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Recipient : Kala Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            08

                            Alcon Inc

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                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aerie Pharmaceuticals Announces Presentations at the American Society of Cataract and Refractive Surgery (ASCR...

                            Details : Rocklatan (netarsudil and latanoprost), indicated for reduction of elevated IOP in patients with glaucoma or ocular hypertension, demonstrated consistent IOP reduction of ~9.5 mmHg and an average IOP reduction of 37% from baseline in European Phase 3B cl...

                            Brand Name : Rocklatan

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 20, 2022

                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $168.0 million

                            Deal Type : Expanded Collaboration

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                            Aerie Concludes Exclusive License Agreement With Santen for Rhopressa® and Rocklatan® in Europe and Several ...

                            Details : Santen will be responsible for all development and commercialization costs and activities related to the products in the territories covered by the agreement with the exception of a post-marketing clinical study to be conducted by Aerie in Europe for Rho...

                            Brand Name : Rhopressa

                            Molecule Type : Small molecule

                            Upfront Cash : $88.0 million

                            December 07, 2021

                            Lead Product(s) : Netarsudil

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Santen Pharmaceutical

                            Deal Size : $168.0 million

                            Deal Type : Expanded Collaboration

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                            Alcon Inc

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                            Alcon Inc

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                            Lead Product(s) : Netarsudil Mesylate,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Aerie Pharmaceuticals Announces Positive Phase 3 Topline Results for Netarsudil Ophthalmic Solution 0.02% Clin...

                            Details : Netarsudil 0.02% is known by the name Rhokiinsa® in the European Union, where it is approved for the reduction of elevated IOP in adult patients with primary open-angle glaucoma or ocular hypertension.

                            Brand Name : Roclanda

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 12, 2021

                            Lead Product(s) : Netarsudil Mesylate,Latanoprost

                            Therapeutic Area : Ophthalmology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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