Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Alector Shares AL002 Phase 2 Data in Early Alzheimer’s Disease
Details : AL002 is a humanized monoclonal antibody that targets the triggering receptor expressed on myeloid cells 2 (TREM2). It was being investigated for early Alzheimer’s disease.
Product Name : AL002
Product Type : Large molecule
Upfront Cash : Not Applicable
November 26, 2024
Alector Announces Closing of Public Offering
Details : Proceeds will fund research, development, and manufacturing of AL001 (latozinemab), a progranulin modulator for frontotemporal dementia with progranulin mutation.
Product Name : AL001
Product Type : Large molecule
Upfront Cash : Undisclosed
February 19, 2024
Alector Announces First Patient Dosed in Progress-Ad Phase 2 Clinical Trial
Details : AL101 (GSK4527226) is an investigational monoclonal antibody targeting the sortilin receptor, developed for treating early Alzheimer’s disease, including mild cognitive impairment and dementia.
Product Name : AL101
Product Type : Large molecule
Upfront Cash : Not Applicable
February 08, 2024
FDA Grants Breakthrough Designation To Latozinemab for FTD-GRN
Details : AL001 (latozinemab) is an investigational monoclonal antibody designed to modulate progranulin, developed for treating frontotemporal dementia due to a progranulin gene mutation.
Product Name : AL001
Product Type : Large molecule
Upfront Cash : Not Applicable
February 07, 2024
Alector Announces Pricing of Public Offering of Common Stock
Details : Proceeds will fund research, development, and manufacturing of AL001 (latozinemab), a progranulin modulator for frontotemporal dementia with progranulin mutation.
Product Name : AL001
Product Type : Large molecule
Upfront Cash : Undisclosed
January 17, 2024
Lead Product(s) : AL003
Therapeutic Area : Neurology
Study Phase : Phase I
Sponsor : AbbVie Inc
Deal Size : $225.0 million
Deal Type : Termination
AbbVie Dumps An Early-Alzheimer's Candidate Developing In Collaboration With Alector
Details : The Company, in collaboration with AbbVie pursuant to the AbbVie Agreement, continues to develop the Company’s AL003 program, which is focused on targeting Triggering Receptor Expressed on Myeloid cells 2 (TREM2), for the treatment of Alzheimer’s dis...
Product Name : AL003
Product Type : Large molecule
Upfront Cash : $205.0 million
June 30, 2022
Lead Product(s) : AL003
Therapeutic Area : Neurology
Highest Development Status : Phase I
Sponsor : AbbVie Inc
Deal Size : $225.0 million
Deal Type : Termination
Alector to Present New AL001 Data at AD/PD™ 2022
Details : AL001 is being studied in Phase 2 trial for the treatment of frontotemporal dementia patients with a C9orf72 mutation (FTD-C9orf72). FTD-C9orf72 is associated with abnormal accumulation of the protein TDP-43.
Product Name : AL001
Product Type : Large molecule
Upfront Cash : Not Applicable
March 08, 2022
Details : GSK and Alector to co-develop progranulin-elevating monoclonal antibodies, AL001 and AL101, for a range of neurodegenerative diseases, including frontotemporal dementia, amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease.
Product Name : AL001
Product Type : Large molecule
Upfront Cash : $700.0 million
July 02, 2021
Lead Product(s) : AL002
Therapeutic Area : Neurology
Study Phase : Phase II
Sponsor : AbbVie Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AL002 is an investigational humanized monoclonal antibody that targets triggering receptor expressed on myeloid cells 2 (TREM2) with the most important genetic links to sporadic Alzheimer’s disease.
Product Name : AL002
Product Type : Large molecule
Upfront Cash : Not Applicable
January 25, 2021
Lead Product(s) : AL002
Therapeutic Area : Neurology
Highest Development Status : Phase II
Sponsor : AbbVie Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Alector Announces Publication of Preclinical and Phase 1 Data Validating Potential of AL002
Details : AL002 was shown to be well-tolerated in a first-in-human Phase 1 SAD study in healthy volunteers and modulated cerebrospinal fluid biomarkers indicative of brain target engagement.
Product Name : AL002
Product Type : Large molecule
Upfront Cash : Not Applicable
June 25, 2020