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    [{"orgOrder":0,"company":"Alentis Therapeutics","sponsor":"Morningside Venture","pharmaFlowCategory":"D","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Large molecule","year":"2021","type":"Series B Financing","leadProduct":"ALE.F02","moa":"Claudin-1","graph1":"Hepatology (Liver, Pancreatic, Gall Bladder)","graph2":"Phase I","graph3":"Alentis Therapeutics","amount2":0.070000000000000007,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Hepatology","amount2New":0.070000000000000007,"dosageForm":"","sponsorNew":"Alentis Therapeutics \/ Morningside Venture","highestDevelopmentStatusID":"6","companyTruncated":"Alentis Therapeutics \/ Morningside Venture"},{"orgOrder":0,"company":"Alentis Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Hepatology (Liver, Pancreatic, Gall Bladder)","country":"","productType":"Large molecule","year":"2022","type":"Not 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                            01

                            Alentis Therapeutics

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                            Lead Product(s) : ALE.P02

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Receives FDA IND Clearance For ALE.P02 For Squamous Cancers

                            Details : ALE.P02 is a first-in-class ADC designed by linking a tubulin inhibitor, a potent cancer drug. It is being evaluated for the treatment of squamous cancers.

                            Brand Name : ALE.P02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 02, 2024

                            Lead Product(s) : ALE.P02

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Alentis Therapeutics

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                            Lead Product(s) : Lixudebart

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Receives FDA ODD for Lixudebart to Treat Idiopathic Pulmonary Fibrosis

                            Details : ALE.F02 (Lixudebart) is a claudin 1 inhibitor ADC, which is currently being evaluated for the treatment of Idiopathic Pulmonary Fibrosis.

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 29, 2024

                            Lead Product(s) : Lixudebart

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Alentis Therapeutics

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                            Lead Product(s) : Lixudebart,Rituximab,GlucoCorticoid

                            Therapeutic Area : Immunology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Doses First ANCA-Associated Vasculitis Rapidly Progressive Glomerulonephritis Patient in ...

                            Details : ALE.F02 (Lixudebart Rituximab GlucoCorticoid) is a claudin 1 inhibitor antibody drug candidate, which is currently being evaluated for the treatment of antineutrophil cytoplasmic antibody-associated vasculitis with rapidly progressive glomerulonephritis.

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 05, 2023

                            Lead Product(s) : Lixudebart,Rituximab,GlucoCorticoid

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Alentis Therapeutics

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                            Lead Product(s) : ALE.C04,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Doses First Patient in Phase 1/2 Clinical Trial of ALE.C04 in Head and Neck Squamous Cell...

                            Details : ALE.C04, a first-in-class monoclonal antibody developed to specifically target exposed CLDN1 on cancer cells, is being developed in Phase 1/2 as a single agent and in combination with pembrolizumab for recurrent or metastatic head and neck squamous cell ...

                            Brand Name : ALE.C04

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 16, 2023

                            Lead Product(s) : ALE.C04,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Alentis Therapeutics

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                            Lead Product(s) : ALE.C04

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Receives FDA Fast Track Designation for ALE.C04 for the Treatment of Claudin-1 Positive H...

                            Details : ALE.C04 is a first-in-class monoclonal antibody developed to specifically target exposed CLDN1 on cancer cells. This investigational antibody is designed to treat patients with recurrent or metastatic, CLDN1-positive HNSCC.

                            Brand Name : ALE.C04

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 24, 2023

                            Lead Product(s) : ALE.C04

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Reports Positive Topline Results From Phase 1 Multiple-ascending Dose Cohorts Study

                            Details : ALE.F02 is a mAb which works by targeting Claudin-1 (CLDN1), designed with a silenced effector function to target the stiff ECM of fibrotic tissues and organs and is currently under development for kidney, lung, and liver fibrosis.

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 26, 2023

                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Alentis Therapeutics

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                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I

                            Sponsor : Jeito Capital

                            Deal Size : $105.0 million

                            Deal Type : Series C Financing

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Closes $105 Million Series C Funding to Advance Transformational Medicines for Claudin-1

                            Details : The financing will support Phase II and Phase I programs of Alentis’ lead investigational products ALE.F02 and ALE.C04 respectively as well as the CLDN1 platform development.

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            April 13, 2023

                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I

                            Sponsor : Jeito Capital

                            Deal Size : $105.0 million

                            Deal Type : Series C Financing

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                            08

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                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Positive Results from Single Ascending Dose Phase 1 Study of ALE.F02 Targeting Claudin-1

                            Details : ALE.F02 is a highly selective anti-CLDN1 mAb that recognizes pathological overexpressed and conformation-dependent CLDN1 epitopes on transformed epithelial cells and is being investigated for the treatment of fibrotic disease in the kidney, lung and live...

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 09, 2023

                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Alentis Therapeutics

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                            Alentis Therapeutics

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                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Starts First-in-Human Clinical Trial for the Treatment of Liver and Kidney Fibrosis

                            Details : Alentis dosed first cohort of healthy participants in Phase 1 clinical trial of ALE.F02, a monoclonal antibody highly selective for Claudin-1 for treatment of liver and kidney fibrosis. ALE.F02 has demonstrated compelling safety and efficacy in preclinic...

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 04, 2022

                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Study Phase : Preclinical

                            Sponsor : Morningside Venture

                            Deal Size : $67.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Alentis Therapeutics Raises USD 67 Million in Series B Financing

                            Details : Alentis’ lead molecules ALE.F02 and ALE.C04 are highly selective anti-Claudin-1 mAb that recognize pathological overexpressed and conformation-dependent Claudin-1 epitopes in fibrotic disease and cancer.

                            Brand Name : ALE.F02

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            June 15, 2021

                            Lead Product(s) : ALE.F02

                            Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                            Highest Development Status : Preclinical

                            Sponsor : Morningside Venture

                            Deal Size : $67.0 million

                            Deal Type : Series B Financing

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