Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TH103
Therapeutic Area : Ophthalmology
Study Phase : Phase I
Sponsor : Kalaris Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
AlloVir & Kalaris Merge, Focus on Retinal Disease Therapies
Details : The combined company will focus on the development of TH103, a fully humanized, recombinant fusion protein, for patients with neovascular age-related macular degeneration.
Brand Name : TH103
Molecule Type : Large molecule
Upfront Cash : Undisclosed
November 08, 2024
Lead Product(s) : TH103
Therapeutic Area : Ophthalmology
Highest Development Status : Phase I
Sponsor : Kalaris Therapeutics
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALVR105 (posoleucel) is a T-lymphocyte cell therapy which is under phase 3 clinical development for the treatment of adenovirus infections, BK virus infections & Epstein-Barr virus infection.
Brand Name : ALVR105
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 22, 2023
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : J.P. Morgan
Deal Size : $7.5 million
Deal Type : Public Offering
AlloVir Announces Pricing of Public Offering of Common Stock
Details : The company intends to use the net proceeds to complete enrollment and achieve data readouts in all three of its ongoing Phase 3 trials of its lead multi-virus specific candidate, Viralym-M (posoleucel), an allogeneic, off-the-shelf multi-virus specific ...
Brand Name : Viralym-M
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
June 21, 2023
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : J.P. Morgan
Deal Size : $7.5 million
Deal Type : Public Offering
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Viralym-M (posoleucel) is a multi-virus specific T cell therapy (VST) targeting five viral pathogens ((BKV), (CMV), (AdV), (EBV), HHV-6). It is designed to play an important role in providing bridging immunity between conditioning and reconstitution of t...
Brand Name : Viralym-M
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
February 15, 2023
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
AlloVir Announces Plans to Complete Enrollment in Three Phase 3 Posoleucel Studies in 2023
Details : Viralym-M (posoleucel) is a multi-virus specific T cell therapy (VST) targeting five viral pathogens ((BKV), (CMV), (AdV), (EBV), HHV-6). It is designed to play an important role in providing bridging immunity between conditioning and reconstitution of t...
Brand Name : Viralym-M
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
January 09, 2023
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Kite Pharma
Deal Size : $126.6 million
Deal Type : Public Offering
AlloVir Announces $126.6 Million Registered Direct Offering
Details : AlloVir intends to use the net proceeds from the offering, to complete enrollment and achieve data readouts in all three of the Company’s ongoing Phase 3 trials of its lead multi-virus specific T-cell therapy candidate, posoleucel (Viralym-M).
Brand Name : Viralym-M
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
July 27, 2022
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Kite Pharma
Deal Size : $126.6 million
Deal Type : Public Offering
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AlloVir’s lead product, posoleucel (Viralym-M, ALVR105), is in late-stage clinical development as an allogeneic, off-the-shelf, multi-virus-specific T cell therapy targeting six viral pathogens in immunocompromised individuals.
Brand Name : ALVR105
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 07, 2022
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The new RMAT designation was based on initial data from an open-label Phase 2 study evaluating the potential for posoleucel to prevent life-threatening infections from six common viruses following allo-HCT.
Brand Name : ALVR105
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 20, 2022
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Updated, preliminary Phase 2 data presented at EBMT Annual Meeting continue to demonstrate substantial reduction in the expected rate of clinically significant infections with posoleucel therapy.
Brand Name : ALVR105
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 22, 2022
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The company’s Phase 3 study of posoleucel for the treatment of virus-associated HC is ongoing and enrolling adult and pediatric patients following allogeneic HSCT (allo-HSCT).
Brand Name : ALVR105
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
October 04, 2021
Lead Product(s) : Posoleucel
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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