Lead Product(s) : ALRN-6924
Therapeutic Area : Dermatology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALRN-6924 is an MDM2/MDMX inhibitor that leverages Aileron’s proprietary peptide drug technology. The primary endpoint of the Phase 1b open-label trial was duration and incidence of severe neutropenia in cycle 1.
Brand Name : ALRN-6924
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 21, 2023
Lead Product(s) : ALRN-6924
Therapeutic Area : Dermatology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924
Therapeutic Area : Dermatology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The primary endpoints are duration and incidence of severe neutropenia (Grade 4) in cycle 1. Secondary endpoints include the chemoprotective effect of ALRN-6924 on chemotherapy-induced alopecia, as well as other hematologic and non-hematologic toxicities...
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 30, 2022
Lead Product(s) : ALRN-6924
Therapeutic Area : Dermatology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Enhancements to protocol, informed by recent ALRN-6924 data, are designed to improve the opportunity to demonstrate protection against chemotherapy-induced severe neutropenia, alopecia (hair loss) and potentially other toxicities in patients with p53-mut...
Brand Name : ALRN-6924
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 01, 2022
Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Carboplatin,Pemetrexed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALRN-6924, first-in-class MDM2/MDMX dual inhibitor, is designed to activate p53, which in turn upregulates p21, a known inhibitor of the cell replication cycle. ALRN-6924 is the only reported chemoprotective agent in clinical development to employ a biom...
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
June 29, 2022
Lead Product(s) : ALRN-6924,Carboplatin,Pemetrexed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Aileron is developing ALRN-6924 to protect patients with p53 mutated cancers against chemotherapy-induced bone marrow toxicities and other toxicities.
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
May 19, 2022
Lead Product(s) : ALRN-6924,Doxorubicin Hydrochloride,Cyclophosphamide
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Paclitaxel
Therapeutic Area : Dermatology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Non-clinical data demonstrated principle that ALRN-6924 can temporarily arrest cell cycle in human scalp hair follicles and their stem cells also ALRN-6924-induced cell cycle arrest protected hair follicles from paclitaxel-induced toxicity and irreversib...
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
May 10, 2022
Lead Product(s) : ALRN-6924,Paclitaxel
Therapeutic Area : Dermatology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ALRN-6924 is first-in-class MDM2/MDMX dual inhibitor, is designed to activate p53, which in turn upregulates p21
Brand Name : ALRN-6924
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 07, 2021
Lead Product(s) : ALRN-6924,Topotecan Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : A precision medicine-based chemoprotective agent, ALRN-6924 is designed to selectively activate p53 in normal cells, thereby upregulating p21, which pauses cell cycle in normal cells but not in p53-mutated cancer cells.
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 16, 2021
Lead Product(s) : ALRN-6924,Topotecan Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Carboplatin,Pemetrexed
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Initial findings from an ongoing study demonstrated that a 0.3 mg/kg dose of ALRN-6924 has been very well tolerated and resulted in p53-mediated induction of the cell cycle inhibitor p21 in normal bone marrow cells in healthy volunteers.
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Not Applicable
August 27, 2021
Lead Product(s) : ALRN-6924,Carboplatin,Pemetrexed
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ALRN-6924,Carboplatin
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Acorn Bioventures
Deal Size : $35.9 million
Deal Type : Public Offering
Aileron Therapeutics Announces Completion of $35.9 Million Registered Direct Offering
Details : Aileron is developing ALRN-6924 as a novel medicine to selectively protect healthy cells in patients with cancers that harbor p53 mutations to reduce or eliminate chemotherapy-induced side effects while preserving chemotherapy’s effects against cancer ...
Brand Name : ALRN-6924
Molecule Type : Peptide
Upfront Cash : Undisclosed
January 11, 2021
Lead Product(s) : ALRN-6924,Carboplatin
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Acorn Bioventures
Deal Size : $35.9 million
Deal Type : Public Offering
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