[{"orgOrder":0,"company":"Alumis","sponsor":"Kaken Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Collaboration","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0.17999999999999999,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0.17999999999999999,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Kaken Pharmaceuticals","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Kaken Pharmaceuticals"},{"orgOrder":0,"company":"Alumis","sponsor":"Foresite Capital","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Series C Financing","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Foresite Capital","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Foresite Capital"},{"orgOrder":0,"company":"Alumis","sponsor":"Foresite Capital","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Series A Financing","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Foresite Capital","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Foresite Capital"},{"orgOrder":0,"company":"Alumis","sponsor":"AyurMaya","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Series B Financing","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ AyurMaya","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ AyurMaya"},{"orgOrder":0,"company":"Alumis","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Public Offering","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Morgan Stanley","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Morgan Stanley"},{"orgOrder":0,"company":"Alumis","sponsor":"Morgan Stanley","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Public Offering","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Morgan Stanley","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Morgan Stanley"},{"orgOrder":0,"company":"Alumis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"A-005","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Alumis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Alumis \/ Inapplicable"},{"orgOrder":0,"company":"Alumis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"A-005","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Alumis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Alumis \/ Inapplicable"},{"orgOrder":0,"company":"Alumis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"ESK-001","moa":"TYK2","graph1":"Dermatology","graph2":"Phase III","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Alumis \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Alumis \/ Inapplicable"},{"orgOrder":0,"company":"Alumis","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"A-005","moa":"Undisclosed","graph1":"Neurology","graph2":"Phase I","graph3":"Alumis","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Alumis \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Alumis \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals by Alumis

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : The collaboration aims to develop, manufacture and commercialize ESK-001, a highly selective, next-gen oral TYK2 inhibitor, for dermatology indications in Japan.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : $40.0 million

                          March 25, 2025

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase III

                          Sponsor : Kaken Pharmaceuticals

                          Deal Size : $180.0 million

                          Deal Type : Collaboration

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                          02

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : A-005 is a potential first-in-class, brain penetrant tyrosine kinase 2 (TYK2) inhibitor being developed for the treatment of multiple sclerosis (MS), Parkinson’s Disease.

                          Product Name : A-005

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 19, 2024

                          Lead Product(s) : A-005

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : An oral, allosteric TYK2 inhibitor called ESK-001, is being investigated into phase 3 clinical trial for the treatment of moderate to severe plaque psoriasis.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 29, 2024

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : The net proceeds from the offering are intended for the development of its lead asset, an allosteric TYK2 inhibitor called ESK-001, into multiple phase 3 trials in moderate to severe plaque psoriasis.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 27, 2024

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $250.0 million

                          Deal Type : Public Offering

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                          05

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : The proceeds will fund clinical development for company's product candidates, including ESK-001, a TYK2 inhibitor currently in clinical development for moderate to severe plaque psoriasis and SLE.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 27, 2024

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Morgan Stanley

                          Deal Size : $250.0 million

                          Deal Type : Public Offering

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                          06

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Alumis will use the financing proceeds to begin Phase 3 clinical trials for ESK-001, a highly selective allosteric TYK2 inhibitor, developed for moderate to severe plaque psoriasis patients.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 03, 2024

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase II

                          Sponsor : Foresite Capital

                          Deal Size : $259.0 million

                          Deal Type : Series C Financing

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                          07

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : A-005 is a potential first-in-class CNS penetrant tyrosine kinase 2 inhibitor being developed for neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and parkinson’s disease.

                          Product Name : A-005

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 30, 2024

                          Lead Product(s) : A-005

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : A-005 is a potential first-in-class TYK2 inhibitor for treating multiple sclerosis, Parkinson’s Disease, and other neuroinflammatory diseases.

                          Product Name : A-005

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          January 03, 2024

                          Lead Product(s) : A-005

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Proceeds from the financing will be used to continue to advance Alumis’ pipeline, led by ESK-001, a highly selective and potentially best in class TYK2 inhibitor with greater selectivity for TYK2 over JAK1 compared to current therapies in clinical deve...

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          June 01, 2022

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : AyurMaya

                          Deal Size : $200.0 million

                          Deal Type : Series B Financing

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                          10

                          BePharma
                          Not Confirmed
                          BePharma
                          Not Confirmed

                          Details : Esker’s pipeline is led by ESK-001, a highly selective TYK2 inhibitor with greater selectivity for TYK2 over JAK1 compared to current therapies in development.

                          Product Name : ESK-001

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          May 05, 2021

                          Lead Product(s) : ESK-001

                          Therapeutic Area : Dermatology

                          Highest Development Status : Phase I

                          Sponsor : Foresite Capital

                          Deal Size : $70.0 million

                          Deal Type : Series A Financing

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