Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Kaken Pharmaceuticals
Deal Size : $180.0 million
Deal Type : Collaboration
Alumis, Kaken Partner on ESK-001 for Dermatology in Japan
Details : The collaboration aims to develop, manufacture and commercialize ESK-001, a highly selective, next-gen oral TYK2 inhibitor, for dermatology indications in Japan.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : $40.0 million
March 25, 2025
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Kaken Pharmaceuticals
Deal Size : $180.0 million
Deal Type : Collaboration
Alumis Announces Positive Phase 1 Data for CNS Penetrant TYK2 Inhibitor, A-005
Details : A-005 is a potential first-in-class, brain penetrant tyrosine kinase 2 (TYK2) inhibitor being developed for the treatment of multiple sclerosis (MS), Parkinson’s Disease.
Product Name : A-005
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 19, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Alumis Initiates ONWARD Phase 3 Program for ESK-001 in Plaque Psoriasis
Details : An oral, allosteric TYK2 inhibitor called ESK-001, is being investigated into phase 3 clinical trial for the treatment of moderate to severe plaque psoriasis.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 29, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Morgan Stanley
Deal Size : $250.0 million
Deal Type : Public Offering
Alumis Announces Pricing of Initial Public Offering
Details : The net proceeds from the offering are intended for the development of its lead asset, an allosteric TYK2 inhibitor called ESK-001, into multiple phase 3 trials in moderate to severe plaque psoriasis.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 27, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Morgan Stanley
Deal Size : $250.0 million
Deal Type : Public Offering
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Morgan Stanley
Deal Size : $250.0 million
Deal Type : Public Offering
Therapy developer Alumis prices U.S. IPO at about $902M
Details : The proceeds will fund clinical development for company's product candidates, including ESK-001, a TYK2 inhibitor currently in clinical development for moderate to severe plaque psoriasis and SLE.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 27, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Morgan Stanley
Deal Size : $250.0 million
Deal Type : Public Offering
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase II
Sponsor : Foresite Capital
Deal Size : $259.0 million
Deal Type : Series C Financing
Alumis Secures $259M Series C Financing for Immune Dysfunction Therapies
Details : Alumis will use the financing proceeds to begin Phase 3 clinical trials for ESK-001, a highly selective allosteric TYK2 inhibitor, developed for moderate to severe plaque psoriasis patients.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 03, 2024
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase II
Sponsor : Foresite Capital
Deal Size : $259.0 million
Deal Type : Series C Financing
Alumis Doses First Participant in Phase 1 Trial of CNS TYK2 Inhibitor A-005
Details : A-005 is a potential first-in-class CNS penetrant tyrosine kinase 2 inhibitor being developed for neuroinflammatory and neurodegenerative diseases such as multiple sclerosis and parkinson’s disease.
Product Name : A-005
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 30, 2024
Lead Product(s) : A-005
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Alumis Presents Preclinical Data for Allosteric TYK2 Inhibitor A-005 at ACTRIMS
Details : A-005 is a potential first-in-class TYK2 inhibitor for treating multiple sclerosis, Parkinson’s Disease, and other neuroinflammatory diseases.
Product Name : A-005
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
January 03, 2024
Lead Product(s) : A-005
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase I
Sponsor : AyurMaya
Deal Size : $200.0 million
Deal Type : Series B Financing
Details : Proceeds from the financing will be used to continue to advance Alumis’ pipeline, led by ESK-001, a highly selective and potentially best in class TYK2 inhibitor with greater selectivity for TYK2 over JAK1 compared to current therapies in clinical deve...
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
June 01, 2022
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase I
Sponsor : AyurMaya
Deal Size : $200.0 million
Deal Type : Series B Financing
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Study Phase : Phase I
Sponsor : Foresite Capital
Deal Size : $70.0 million
Deal Type : Series A Financing
Esker Therapeutics Launches to Transform the Treatment of Autoimmune Diseases
Details : Esker’s pipeline is led by ESK-001, a highly selective TYK2 inhibitor with greater selectivity for TYK2 over JAK1 compared to current therapies in development.
Product Name : ESK-001
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
May 05, 2021
Lead Product(s) : ESK-001
Therapeutic Area : Dermatology
Highest Development Status : Phase I
Sponsor : Foresite Capital
Deal Size : $70.0 million
Deal Type : Series A Financing