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                          Antibody Engineering
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                          Antibody Engineering
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                          Details : ALX148 (evorpacept), a next generation CD47 blocker and SARCLISA (isatuximab), Sanofi’s monoclonal antibody that targets CD38 receptor are being investigates as combination for R/R Multiple Myeloma.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 04, 2024

                          Lead Product(s) : Evorpacept,Isatuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Sanofi

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 31, 2024

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX 148 (evorpacept) is a highly differentiated anti-CD47 blocker with an inactive Fc effector function. It is being evaluated for untreated HPV-mediated oropharyngeal cancer.

                          Brand Name : ALX 148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 30, 2024

                          Lead Product(s) : Evorpacept,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept), ALX Oncology’s lead candidate, is being tested with Rituximab and Lenalidomide for relapsed or refractory B-cell non-Hodgkin lymphoma.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 09, 2024

                          Lead Product(s) : Evorpacept,Rituximab,Lenalidomide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 10, 2023

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Piper Sandler

                          Deal Size : $63.2 million

                          Deal Type : Public Offering

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 05, 2023

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Piper Sandler

                          Deal Size : $55.0 million

                          Deal Type : Public Offering

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX Oncology will use the proceeds to fund ongoing development of ALX148 (evorpacept), a next generation CD47 blocking therapeutic that combines a high-affinity CD47 binding domain with an inactivated, proprietary Fc domain, for hematologic and solid mal...

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 04, 2023

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Piper Sandler

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in combination with trastuzumab in patients with HER2-positive gastric/gastroesophageal junction (“GEJ”) cancer.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 03, 2023

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept) is a fusion protein comprised of an engineered high affinity CD47 binding domain of SIRPα linked to an inactive Fc region of human immunoglobulin, being developed for the treatment of myelodysplastic syndromes.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 10, 2023

                          Lead Product(s) : Evorpacept,Azacitidine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALX148 (evorpacept) is a next generation CD47 blocker, which is being investigated in patients with gastric cancer and gastroesophageal junction adenocarcinoma.

                          Brand Name : ALX148

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 26, 2023

                          Lead Product(s) : Evorpacept,Trastuzumab,Ramucirumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Eli Lilly

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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