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Diseases","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Horizon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Horizon Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Horizon Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Rare Diseases and Disorders","country":"IRELAND","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Inebilizumab","moa":"CD19","graph1":"Rare Diseases and Disorders","graph2":"Approved FDF","graph3":"Horizon Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Horizon Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Horizon Therapeutics \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by Amgen Inc

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                            01

                            Amgen Inc

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                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            US FDA Approves Amgen's Uplizna as First Treatment for Rare Immune Disorder

                            Details : Uplizna (inebilizumab) is a CD19-directed cytolytic antibody which is being investigated for the treatment of pattients with Immunoglobulin G4-related disease.

                            Product Name : Uplizna

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            April 03, 2025

                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Amgen Inc

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                            Lead Product(s) : Rocatinlimab

                            Therapeutic Area : Dermatology

                            Study Phase : Phase III

                            Sponsor : Kyowa Kirin

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen and Kyowa Kirin Report Top-Line Results from Rocatinlimab Phase 3 Study

                            Details : AMG 451 (rocatinlimab) is an anti-OX40 mAb that inhibits and reduces the number of OX40+ pathogenic T cells responsible for driving systemic and local atopic dermatitis inflammatory responses.

                            Product Name : AMG 451

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 08, 2025

                            Lead Product(s) : Rocatinlimab

                            Therapeutic Area : Dermatology

                            Highest Development Status : Phase III

                            Sponsor : Kyowa Kirin

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Amgen Inc

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                            Lead Product(s) : AMG 513

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen’s Early-Stage Obesity Asset Put on Clinical Hold by FDA

                            Details : AMG 513 is an injectable medicine being developed by Amgen for the treatment of cardiometabolic diseases like obesity. The mechanism of action is currently undefined.

                            Product Name : AMG 513

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            February 05, 2025

                            Lead Product(s) : AMG 513

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Amgen Inc

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                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            EU Approves Blincyto for CD19+ B-Cell ALL in Consolidation Phase

                            Details : Blincyto (blinatumomab, targets CD19/CD3) has been approved by FDA for adults with newly diagnosed Philadelphia chromosome-negative CD19-positive B-cell precursor acute lymphoblastic leukemia (B-ALL).

                            Product Name : Blincyto

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 29, 2025

                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Amgen Inc

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                            Lead Product(s) : Sotorasib,Panitumumab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Approves Lumakras® with Vectibix® for Kras G12C-Mutated CRC

                            Details : Lumakras (sotorasib) is a small molecule, KRAS G12C inhibitor. FDA declined approval for KRAS G12C-mutated locally advanced or metastatic colorectal cancer in combination with panitumumab.

                            Product Name : Lumakras

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 16, 2025

                            Lead Product(s) : Sotorasib,Panitumumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

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                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen’s IMDYLLTRA® Granted Marketing Authorisation in UK for SCLC Treatment

                            Details : Imdylltra (tarlatamab) is the first and only DLL3-targeting bispecific T-cell Engager therapy. It is approved as third line treatment for adult patients with extensive-stage small cell lung cancer.

                            Product Name : Imdylltra

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 06, 2025

                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Amgen Inc

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                            Lead Product(s) : Maridebart Cafraglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen's Weight-Loss Drug Fails to Impress in Study; Shares Plunge

                            Details : MariTide (maridebart cafraglutide) is a bispecific GLP-1 agonist & GIPR antagonist antibody peptide conjugate, being evaluated for the treatment of obesity.

                            Product Name : MariTide

                            Product Type : Peptide

                            Upfront Cash : Inapplicable

                            November 26, 2024

                            Lead Product(s) : Maridebart Cafraglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Amgen Inc

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                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen, AZ's Tezspire Excels in Phase 3 Rhinosinusitis Trial

                            Details : Tezspire (tezepelumab) is a thymic stromal lymphopoietin blocker, human monoclonal antibody (IgG2λ). Currently it is being investigated for adults having chronic rhinosinusitis with nasal polyps.

                            Product Name : Tezspire

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            August 11, 2024

                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Amgen Inc

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                            Lead Product(s) : Blinatumomab,Cyclophosphamide,Cytarabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            BLINCYTO® Plus Chemotherapy Improves Survival in Pediatric B-Cell Precursor ALL Patients

                            Details : Blincyto (blinatumomab) is a bispecific CD19-directed CD3 T-cell engager indicated for the treatment of adult and pediatric patients one month or older with CD19-+ve Philadelphia chromosome-ve B-ALL.

                            Product Name : Blincyto

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            July 12, 2024

                            Lead Product(s) : Blinatumomab,Cyclophosphamide,Cytarabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Amgen Inc

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                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Approves BLINCYTO for B-ALL in Consolidation Phase

                            Details : Blincyto (blinatumomab) is a bispecific CD19-directed CD3 T-cell engager indicated for the treatment of adult and pediatric patients one month or older with CD19-+ve Philadelphia chromosome-ve B-ALL.

                            Product Name : Blincyto

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            June 14, 2024

                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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