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KOREA","productType":"Antibody-drug Conjugate","year":"2022","type":"Collaboration","leadProduct":"Undisclosed","moa":"CIDEB","graph1":"Oncology","graph2":"Discovery","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Amgen Inc \/ Amgen Inc","highestDevelopmentStatusID":"2","companyTruncated":"Amgen Inc \/ Amgen Inc"}]

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                            01

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                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            EU Approves Blincyto for CD19+ B-Cell ALL in Consolidation Phase

                            Details : Blincyto (blinatumomab, targets CD19/CD3) has been approved by FDA for adults with newly diagnosed Philadelphia chromosome-negative CD19-positive B-cell precursor acute lymphoblastic leukemia (B-ALL).

                            Product Name : Blincyto

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 29, 2025

                            Lead Product(s) : Blinatumomab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Lead Product(s) : Sotorasib,Panitumumab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            FDA Approves Lumakras® with Vectibix® for Kras G12C-Mutated CRC

                            Details : Lumakras (sotorasib) is a small molecule, KRAS G12C inhibitor. FDA declined approval for KRAS G12C-mutated locally advanced or metastatic colorectal cancer in combination with panitumumab.

                            Product Name : Lumakras

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            January 16, 2025

                            Lead Product(s) : Sotorasib,Panitumumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Lead Product(s) : Etakafusp Alfa,Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : Asher Biotherapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Asher Bio, BeiGene Collaborate on AB248, T-Cell Engager for Lung Cancer

                            Details : As part of this collaboration agreement, Amgen will sponsor a global Phase 1b study to evaluate the early efficacy of AB248 (etakafusp alfa) in combination with Imdelltra in patients with ES-SCLC.

                            Product Name : AB248

                            Product Type : Protein

                            Upfront Cash : Undisclosed

                            January 08, 2025

                            Lead Product(s) : Etakafusp Alfa,Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : Asher Biotherapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            04

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                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Amgen’s IMDYLLTRA® Granted Marketing Authorisation in UK for SCLC Treatment

                            Details : Imdylltra (tarlatamab) is the first and only DLL3-targeting bispecific T-cell Engager therapy. It is approved as third line treatment for adult patients with extensive-stage small cell lung cancer.

                            Product Name : Imdylltra

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 06, 2025

                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            Lead Product(s) : Blinatumomab,Cyclophosphamide,Cytarabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            BLINCYTO® Plus Chemotherapy Improves Survival in Pediatric B-Cell Precursor ALL Patients

                            Details : Blincyto (blinatumomab) is a bispecific CD19-directed CD3 T-cell engager indicated for the treatment of adult and pediatric patients one month or older with CD19-+ve Philadelphia chromosome-ve B-ALL.

                            Product Name : Blincyto

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 07, 2024

                            Lead Product(s) : Blinatumomab,Cyclophosphamide,Cytarabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Maridebart Cafraglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen's Weight-Loss Drug Fails to Impress in Study; Shares Plunge

                            Details : MariTide (maridebart cafraglutide) is a bispecific GLP-1 agonist & GIPR antagonist antibody peptide conjugate, being evaluated for the treatment of obesity.

                            Product Name : MariTide

                            Product Type : Peptide

                            Upfront Cash : Not Applicable

                            November 26, 2024

                            Lead Product(s) : Maridebart Cafraglutide

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen, AZ's Tezspire Excels in Phase 3 Rhinosinusitis Trial

                            Details : Tezspire (tezepelumab) is a thymic stromal lymphopoietin blocker, human monoclonal antibody (IgG2λ). Currently it is being investigated for adults having chronic rhinosinusitis with nasal polyps.

                            Product Name : Tezspire

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 08, 2024

                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen Inc

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                            Amgen Inc

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                            Lead Product(s) : YL201,Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : MediLink Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            MediLink And YL201 Collaborate on Global Clinical Trial And Supply Agreement

                            Details : Amgen will lead a global clinical study to evaluate the potential of the combination of MediLink's B7-H3-targeting ADC YL201 and Amgen's DLL3- and CD3-targeting BiTE® IMDELLTRA™ in ES-SCLC.

                            Product Name : YL201

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 07, 2024

                            Lead Product(s) : YL201,Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : MediLink Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            Amgen Inc

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                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen’s trial brings new hope for IgG4-RD patients

                            Details : Uplizna (inebilizumab-cdon) is a CD19-directed cytolytic antibody which is being investigated for the treatment of pattients with Immunoglobulin G4-related disease.

                            Product Name : Uplizna

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 06, 2024

                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen Inc

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                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen: Positive Uplizna Phase 3 Trial in Immunoglobulin G4-Related Disease

                            Details : Uplizna (inebilizumab-cdon) is a CD19-directed cytolytic antibody which is being investigated for the treatment of pattients with Immunoglobulin G4-related disease.

                            Product Name : Uplizna

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 05, 2024

                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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