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molecule","year":"2024","type":"Not Applicable","leadProduct":"Eculizumab","moa":"","graph1":"Rare Diseases and Disorders","graph2":"Approved","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Amgen Inc \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Amgen Inc \/ Not Applicable"},{"orgOrder":0,"company":"Amgen Inc","sponsor":"MediLink Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Collaboration","leadProduct":"Tarlatamab","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Amgen Inc","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Amgen Inc \/ Amgen Inc","highestDevelopmentStatusID":"14","companyTruncated":"Amgen Inc \/ Amgen Inc"}]

    Find Clinical Drug Pipeline Developments & Deals by Amgen Inc

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                            01

                            Amgen Inc

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                            Lead Product(s) : YL201,Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Recipient : MediLink Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            MediLink And YL201 Collaborate on Global Clinical Trial And Supply Agreement

                            Details : Amgen will lead a global clinical study to evaluate the potential of the combination of MediLink's B7-H3-targeting ADC YL201 and Amgen's DLL3- and CD3-targeting BiTE® IMDELLTRA™ in ES-SCLC.

                            Brand Name : YL201

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 07, 2024

                            Lead Product(s) : YL201,Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Recipient : MediLink Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            02

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                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen’s trial brings new hope for IgG4-RD patients

                            Details : Uplizna (inebilizumab-cdon) is a CD19-directed cytolytic antibody which is being investigated for the treatment of pattients with Immunoglobulin G4-related disease.

                            Brand Name : Uplizna

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 06, 2024

                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Amgen Inc

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                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen: Positive Uplizna Phase 3 Trial in Immunoglobulin G4-Related Disease

                            Details : Uplizna (inebilizumab-cdon) is a CD19-directed cytolytic antibody which is being investigated for the treatment of pattients with Immunoglobulin G4-related disease.

                            Brand Name : Uplizna

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 05, 2024

                            Lead Product(s) : Inebilizumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Amgen Inc

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                            Lead Product(s) : Eculizumab

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Approves First Interchangeable Biosimilar for Two Rare Diseases

                            Details : Bkemv (eculizumab) is approved by FDA as the first interchangeable biosimilar to Soliris to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

                            Brand Name : Bkemv

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 28, 2024

                            Lead Product(s) : Eculizumab

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

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                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            FDA Approves IMDELLTRA™ (TARLATAMAB-DLLE) for Small Cell Lung Cancer

                            Details : Imdelltra (tarlatamab-dlle) is the first and only DLL3-targeting Bispecific T-cell Engager therapy. It is approved for adult patients with extensive-stage small cell lung cancer (ES-SCLC).

                            Brand Name : Imdelltra

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 16, 2024

                            Lead Product(s) : Tarlatamab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : CX-904

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : CytomX Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            CytomX Announces Positive Phase 1a Data for Monotherapy CX-904 PROBODY® T-Cell Engager

                            Details : CX-904 is a PROBODY T-cell engager targeting EGFR on cancer cells and CD3 on T cells, being evaluated for advanced pancreatic cancer.

                            Brand Name : CX-904

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 08, 2024

                            Lead Product(s) : CX-904

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : CytomX Therapeutics

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Teprotumumab

                            Therapeutic Area : Immunology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen to Submit Teprotumumab MAA to European Medicines Agency

                            Details : Tepezza (teprotumumab) is a fully human anti-IGF-1R monoclonal antibody, which is currently being evaluated, for the treatment of thyroid eye disease.

                            Brand Name : Tepezza

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 26, 2024

                            Lead Product(s) : Teprotumumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen Inc

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                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Amgen to Present TEZSPIRE® Phase 2a Copd Data at ATS 2024

                            Details : Tezspire (tezepelumab) is a thymic stromal lymphopoietin (TSLP) blocker, human monoclonal antibody (IgG2λ). Currently it is being investigated for chronic obstructive pulmonary disease.

                            Brand Name : Tezspire

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 16, 2024

                            Lead Product(s) : Tezepelumab

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Amgen Inc

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                            Lead Product(s) : Denosumab

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            UK MHRA Approves New Formulation of Amgen’s XGEVA

                            Details : Xgeva (denosumab) is a human monoclonal antibody and a RANK ligand inhibitor. Its new formulation is indicated for the treatment of patients with bone metastases.

                            Brand Name : Xgeva

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 01, 2024

                            Lead Product(s) : Denosumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Teprotumumab

                            Therapeutic Area : Immunology

                            Study Phase : Preclinical

                            Recipient : Xeris Pharmaceuticals

                            Deal Size : $75.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Xeris Biopharma Signs Worldwide License Deal for Xeriject Formulation of Teprotumumab

                            Details : Under the agreement, Amgen will develop, manufacture, and commercialize a subcutaneous formulation of Tepezza (teprotumumab) using Xeris’ XeriJect® technology in Thyroid Eye Disease (TED).

                            Brand Name : Tepezza

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            January 10, 2024

                            Lead Product(s) : Teprotumumab

                            Therapeutic Area : Immunology

                            Highest Development Status : Preclinical

                            Recipient : Xeris Pharmaceuticals

                            Deal Size : $75.0 million

                            Deal Type : Licensing Agreement

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