Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase II/ Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition
AstraZeneca Closes Acquisition of Amolyt Pharma
Details : Through the acquisition, AstraZeneca leverages the AZP-3601 (neboparatide), peptide agonist of the PTH1 receptor. Currently, being evaluated for the treatment of Chronic Hypoparathyroidism.
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : $800.0 million
July 15, 2024
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase II/ Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Amolyt Pharma Granted FDA Fast Track for Eneboparatide in Hypoparathyroidism
Details : AZP-3601 (neboparatide) is a peptide agonist of the PTH1 receptor. Currently, being evaluated in the Phase III for Chronic Hypoparathyroidism, Endocrine System Diseases, and Parathyroid Diseases.
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Not Applicable
May 02, 2024
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition
Amolyt Pharma Enters into Definitive Agreement to be Acquired by AstraZeneca
Details : AstraZeneca leverages AZP-3601 (neboparatide), a peptide agonist of the PTH1 receptor, currently in Phase III for treating chronic hypoparathyroidism and related endocrine diseases.
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : $800.0 million
March 14, 2024
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase III
Sponsor : AstraZeneca
Deal Size : $1,050.0 million
Deal Type : Acquisition
Lead Product(s) : AZP-3813
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : PeptiDream
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AZP-3813, a peptide GHR antagonist, is being developed as a potential treatment for acromegaly to be used in combination with somatostatin analogues (SSAs) for patients who do not adequately respond to SSAs alone.
Brand Name : AZP-3813
Molecule Type : Peptide
Upfront Cash : Not Applicable
June 05, 2023
Lead Product(s) : AZP-3813
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : PeptiDream
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AZP-3601 (eneboparatide) targets PTH receptor to safely produce sustained blood levels of calcium and thereby manage the symptoms of hypoparathyroidism, and to limit urine calcium excretion by restoring calcium reabsorption by the kidney, preventing chro...
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Not Applicable
May 02, 2023
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AZP-40XX
Therapeutic Area : Endocrinology
Study Phase : Preclinical
Recipient : XOMA
Deal Size : Undisclosed
Deal Type : Agreement
Amolyt Pharma Announces Research Agreement and Licensing Option with XOMA
Details : Amolyt will advance pre-clinical development of AZP-40XX, an anti-PTHR1 monoclonal antibody, as potential treatments of primary hyperparathyroidism (PHPT) and humoral hypercalcemia of malignancy (HHM).
Brand Name : AZP-40XX
Molecule Type : Large molecule
Upfront Cash : Undisclosed
January 24, 2023
Lead Product(s) : AZP-40XX
Therapeutic Area : Endocrinology
Highest Development Status : Preclinical
Recipient : XOMA
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Sofinnova Partners
Deal Size : $138.0 million
Deal Type : Series C Financing
Details : Amolyt plans to use the proceeds to advance its pipeline of therapeutics for rare endocrine and related disorders, including AZP-3601, now known as eneboparatide, for the treatment of hypoparathyroidism, and AZP-3813 for the treatment of acromegaly.
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Undisclosed
January 06, 2023
Lead Product(s) : Eneboparatide
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Sofinnova Partners
Deal Size : $138.0 million
Deal Type : Series C Financing
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Amolyt Pharma to Present Full Phase 2a Data on AZP-3601 at Upcoming Conferences
Details : AZP-3601 is an investigational therapeutic peptide designed to target a specific conformation of the parathyroid hormone (PTH) receptor to safely produce sustained and stable levels of calcium in the blood and thereby manage the symptoms of hypoparathyro...
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Not Applicable
October 12, 2022
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AZP-3601 is an investigational therapeutic peptide designed to target a specific conformation of the parathyroid hormone (PTH) receptor to safely produce sustained and stable levels of calcium in the blood and thereby manage the symptoms of hypoparathyro...
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Not Applicable
October 12, 2022
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AZP-3601 is an investigational therapeutic peptide designed to target a specific conformation of the parathyroid hormone (PTH) receptor to safely produce sustained and stable levels of calcium in the blood and thereby manage the symptoms of hypoparathyro...
Brand Name : AZP-3601
Molecule Type : Peptide
Upfront Cash : Not Applicable
September 12, 2022
Lead Product(s) : AZP-3601
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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