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Find Clinical Drug Pipeline Developments & Deals by Amylyx Pharmaceuticals

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (taurursodiol and sodium phenylbutyrate) is a glutamine chelator small molecule drug candidate, being evaluated for the treatment of wolfram syndrome.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 17, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (taurursodiol and sodium phenylbutyrate) is a glutamine chelator small molecule drug candidate, being evaluated for the treatment of wolfram syndrome.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 02, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Amylyx Pharmaceuticals acquires Eiger BioPharmaceuticals' experimental drug Avexitide, GLP-1 antagonist. Currently, it is being evaluated for the treatment of Post Bariatric Hypoglycemia.

                          Brand Name : Exendin 9-39

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          July 10, 2024

                          Lead Product(s) : Avexitide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Recipient : Eiger BioPharmaceuticals

                          Deal Size : $35.1 million

                          Deal Type : Acquisition

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Amylyx Pharmaceuticals will acquire Eiger BioPharmaceuticals' experimental drug Avexitide, GLP-1 antagonist. Currently, it is being evaluated for the treatment of Post Bariatric Hypoglycemia.

                          Brand Name : Exendin 9-39

                          Molecule Type : Peptide

                          Upfront Cash : Undisclosed

                          June 22, 2024

                          Lead Product(s) : Avexitide

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Phase II

                          Recipient : Eiger BioPharmaceuticals

                          Deal Size : $35.1 million

                          Deal Type : Acquisition

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (taurursodiol and sodium phenylbutyrate) is an oral small molecule drug candidate under evaluation for treating Wolfram syndrome.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 10, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (sodium phenylbutyrate and taurursodiol) is an oral fixed-dose medication for ALS, with FDA and Health Canada discussions for voluntary discontinuation of marketing authorizations.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 05, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (sodium phenylbutyrate and taurursodiol) is a specially formulated oral fixed-dose combination, which is being evaluated for the treatment of Amyotrophic Lateral Sclerosis.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 08, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Relyvrio (sodium phenylbutyrate and taurursodiol) is an oral, fixed-dose combination. It is a HDAC inhibitor which is being evaluated in phase 2 clinical trials for the treatment of Wolfram syndrome.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 08, 2024

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Amylyx investigational product Relyvrio (sodium phenylbutyrate) with Taurursodiol, is an oral, fixed-dose combination therapy. It is being evaluated in the Phase III clinical trial studies with patient for the treatment of Progressive Supranuclear Palsy.

                          Brand Name : Relyvrio

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 22, 2023

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : AMX0035 (sodium phenylbutyrate and ursodoxicoltaurine [also known as taurursodiol]), under the trade name Albrioza, received negative opinion from CHMP, for the treatment of amyotrophic lateral sclerosis (ALS).

                          Brand Name : AMX0035

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 13, 2023

                          Lead Product(s) : Sodium Phenylbutyrate,Tauroursodeoxycholic Acid

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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