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Find Clinical Drug Pipeline Developments & Deals by Antios Therapeutics

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                          01

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : Following 90 days of dosing, ATI-2173, in combination with tenofovir disoproxil fumarate (TDF), was generally well-tolerated with alanine aminotransferase (ALT) normalization and no ALT flares off-treatment.

                          Brand Name : ATI-2173

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 25, 2022

                          Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : ATI-1428 and ATI-1645 are 4th generation, class II capsid assembly modulators (CAMs), both with a novel and unique ultra-potent mechanism of action design that may provide for a more targeted, productive antiviral response by the immune system.

                          Brand Name : ATI-1428

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 08, 2022

                          Lead Product(s) : ATI-1428

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : ATI-2173, once-daily, oral drug candidate for treating HBV, is an investigational phosphoramidate prodrug of clevudine monophosphate, only active site polymerase inhibitor nucleotide for HBV in clinical development.

                          Brand Name : ATI-2173

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 26, 2022

                          Lead Product(s) : Clevudine Monophosphate Prodrug,Tenofovir,Vebicorvir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : The data showed that ATI-2173 alone, or in combination with tenofovir disoproxil fumarate (TDF), was generally well-tolerated among the cohorts, and ATI-2173 and TDF suppressed HBV DNA and induced declines in biomarkers of cccDNA activity.

                          Brand Name : ATI-2173

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 30, 2022

                          Lead Product(s) : Clevudine Monophosphate Prp,Tenofovir Disoproxil Fumarate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : Under the agreement, Antios will purchase the IP rights to a novel series of fourth-generation capsid assembly modulators (CAMs) which is being developed for the treatment of HBV.

                          Brand Name : Undisclosed

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 15, 2021

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Recipient : IRBM

                          Deal Size : $50.0 million

                          Deal Type : Acquisition

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                          06

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : The proceeds from this financing will be used to advance the clinical development of ATI-2173, Antios’ lead Phase 2b clinical candidate. ATI-2173 is the only Active Site Polymerase Inhibitor Nucleotide (ASPIN) in clinical development.

                          Brand Name : ATI-2173

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          November 03, 2021

                          Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate,AB-729

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : GordonMD Global Investments

                          Deal Size : $75.0 million

                          Deal Type : Series B Financing

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                          07

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : ATI-2173 has, to date, demonstrated a generally well-tolerated safety profile, leveraging a unique ASPIN mechanism in clinical development to empower combination therapy.

                          Brand Name : ATI-2173

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          October 19, 2021

                          Lead Product(s) : ATI-2173,Vebicorvir

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Recipient : Assembly Biosciences

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          08

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : The multi-center, double-blinded, placebo-controlled, multiple-dose cohort will evaluate the safety, pharmacokinetics, immunogenicity, and antiviral activity of the combination of ATI-2173, AB-729 and Viread.

                          Brand Name : GalNAc-RNAi

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 30, 2021

                          Lead Product(s) : AB-729,ATI-2173,Tenofovir Disoproxil Fumarate

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Recipient : Arbutus Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : The double-blind randomized controlled trial plans to enroll 30 patients and will assess the safety and efficacy of 25mg and 50mg doses of ATI-2173 in combination with tenofovir (TDF) compared with TDF plus ATI-placebo (control) in chronic HBV-infected s...

                          Brand Name : ATI-2173

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 21, 2021

                          Lead Product(s) : ATI-2173

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Compamed
                          Not Confirmed
                          Compamed
                          Not Confirmed

                          Details : The proceeds from this financing will support the ongoing Phase 2 clinical program which is evaluating the potential for the Company’s lead clinical candidate, ATI-2173, to be a backbone of a once-daily curative regimen for chronic hepatitis B.

                          Brand Name : ATI-2173

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          April 13, 2021

                          Lead Product(s) : ATI-2173

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : RA Capital Management

                          Deal Size : $96.0 million

                          Deal Type : Series B Financing

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