Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Following 90 days of dosing, ATI-2173, in combination with tenofovir disoproxil fumarate (TDF), was generally well-tolerated with alanine aminotransferase (ALT) normalization and no ALT flares off-treatment.
Brand Name : ATI-2173
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 25, 2022
Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ATI-1428
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ATI-1428 and ATI-1645 are 4th generation, class II capsid assembly modulators (CAMs), both with a novel and unique ultra-potent mechanism of action design that may provide for a more targeted, productive antiviral response by the immune system.
Brand Name : ATI-1428
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 08, 2022
Lead Product(s) : ATI-1428
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Clevudine Monophosphate Prodrug,Tenofovir,Vebicorvir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ATI-2173, once-daily, oral drug candidate for treating HBV, is an investigational phosphoramidate prodrug of clevudine monophosphate, only active site polymerase inhibitor nucleotide for HBV in clinical development.
Brand Name : ATI-2173
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 26, 2022
Lead Product(s) : Clevudine Monophosphate Prodrug,Tenofovir,Vebicorvir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Clevudine Monophosphate Prp,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The data showed that ATI-2173 alone, or in combination with tenofovir disoproxil fumarate (TDF), was generally well-tolerated among the cohorts, and ATI-2173 and TDF suppressed HBV DNA and induced declines in biomarkers of cccDNA activity.
Brand Name : ATI-2173
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 30, 2022
Lead Product(s) : Clevudine Monophosphate Prp,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Recipient : IRBM
Deal Size : $50.0 million
Deal Type : Acquisition
Details : Under the agreement, Antios will purchase the IP rights to a novel series of fourth-generation capsid assembly modulators (CAMs) which is being developed for the treatment of HBV.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 15, 2021
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Recipient : IRBM
Deal Size : $50.0 million
Deal Type : Acquisition
Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate,AB-729
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : GordonMD Global Investments
Deal Size : $75.0 million
Deal Type : Series B Financing
Antios Therapeutics Raises $75 Million in a Series B-1 Funding to Advance Clinical Programs for HBV
Details : The proceeds from this financing will be used to advance the clinical development of ATI-2173, Antios’ lead Phase 2b clinical candidate. ATI-2173 is the only Active Site Polymerase Inhibitor Nucleotide (ASPIN) in clinical development.
Brand Name : ATI-2173
Molecule Type : Large molecule
Upfront Cash : Undisclosed
November 03, 2021
Lead Product(s) : ATI-2173,Tenofovir Disoproxil Fumarate,AB-729
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : GordonMD Global Investments
Deal Size : $75.0 million
Deal Type : Series B Financing
Lead Product(s) : ATI-2173,Vebicorvir
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Recipient : Assembly Biosciences
Deal Size : Undisclosed
Deal Type : Collaboration
Details : ATI-2173 has, to date, demonstrated a generally well-tolerated safety profile, leveraging a unique ASPIN mechanism in clinical development to empower combination therapy.
Brand Name : ATI-2173
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 19, 2021
Lead Product(s) : ATI-2173,Vebicorvir
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Recipient : Assembly Biosciences
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : AB-729,ATI-2173,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Recipient : Arbutus Biopharma
Deal Size : Undisclosed
Deal Type : Collaboration
Details : The multi-center, double-blinded, placebo-controlled, multiple-dose cohort will evaluate the safety, pharmacokinetics, immunogenicity, and antiviral activity of the combination of ATI-2173, AB-729 and Viread.
Brand Name : GalNAc-RNAi
Molecule Type : Large molecule
Upfront Cash : Undisclosed
June 30, 2021
Lead Product(s) : AB-729,ATI-2173,Tenofovir Disoproxil Fumarate
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Recipient : Arbutus Biopharma
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : ATI-2173
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The double-blind randomized controlled trial plans to enroll 30 patients and will assess the safety and efficacy of 25mg and 50mg doses of ATI-2173 in combination with tenofovir (TDF) compared with TDF plus ATI-placebo (control) in chronic HBV-infected s...
Brand Name : ATI-2173
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 21, 2021
Lead Product(s) : ATI-2173
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ATI-2173
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase II
Sponsor : RA Capital Management
Deal Size : $96.0 million
Deal Type : Series B Financing
Antios Therapeutics Raises $96 Million in a Series B Financing
Details : The proceeds from this financing will support the ongoing Phase 2 clinical program which is evaluating the potential for the Company’s lead clinical candidate, ATI-2173, to be a backbone of a once-daily curative regimen for chronic hepatitis B.
Brand Name : ATI-2173
Molecule Type : Small molecule
Upfront Cash : Undisclosed
April 13, 2021
Lead Product(s) : ATI-2173
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase II
Sponsor : RA Capital Management
Deal Size : $96.0 million
Deal Type : Series B Financing
LOOKING FOR A SUPPLIER?