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    [{"orgOrder":0,"company":"Apeiron Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"AUSTRIA","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"APN01","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Apeiron Biologics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Apeiron Biologics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Apeiron Biologics \/ Not Applicable"},{"orgOrder":0,"company":"Apeiron Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"AUSTRIA","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"APN01","moa":"ACE2","graph1":"Infections and Infectious 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Biologics","sponsor":"Bionomics","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"AUSTRALIA","productType":"Small molecule","year":"2021","type":"Financing","leadProduct":"BNC210","moa":"nAChR Alpha7","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"Apeiron Biologics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Oral suspension","sponsorNew":"Apeiron Biologics \/ Apeiron","highestDevelopmentStatusID":"8","companyTruncated":"Apeiron Biologics \/ Apeiron"},{"orgOrder":0,"company":"Apeiron Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"AUSTRIA","productType":"Large molecule","year":"2021","type":"Not Applicable","leadProduct":"Alunacedase Alfa","moa":"ACE2","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Apeiron Biologics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Inhalational","sponsorNew":"Apeiron Biologics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Apeiron Biologics \/ Not Applicable"},{"orgOrder":0,"company":"Apeiron Biologics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"AUSTRIA","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"Alunacedase Alfa","moa":"ACE2","graph1":"Infections and Infectious Diseases","graph2":"Phase II","graph3":"Apeiron Biologics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Solution","sponsorNew":"Apeiron Biologics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Apeiron Biologics \/ Not Applicable"},{"orgOrder":0,"company":"Apeiron Biologics","sponsor":"Ligand Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"AUSTRIA","productType":"Large molecule","year":"2024","type":"Acquisition","leadProduct":"Dinutuximab","moa":"","graph1":"Technology","graph2":"Approved","graph3":"Apeiron Biologics","amount2":0.13,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Technology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Apeiron Biologics \/ Ligand Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Apeiron Biologics \/ Ligand Pharmaceuticals"}]

    Find Clinical Drug Pipeline Developments & Deals by Apeiron Biologics

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                            01

                            Apeiron Biologics

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                            Lead Product(s) : Dinutuximab

                            Therapeutic Area : Oncology

                            Study Phase : Approved

                            Sponsor : Ligand Pharmaceuticals

                            Deal Size : $128.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Ligand to Acquire APEIRON Biologics AG for $100 Million

                            Details : Ligand acquires Apeiron Biologics pipeline which also includes Qarziba (dinutuximab beta), it is indicated for the treatment of high-risk neuroblastoma in patients aged 12 months and above.

                            Brand Name : Qarziba

                            Molecule Type : Large molecule

                            Upfront Cash : $100.0 million

                            July 08, 2024

                            Lead Product(s) : Dinutuximab

                            Therapeutic Area : Oncology

                            Highest Development Status : Approved

                            Sponsor : Ligand Pharmaceuticals

                            Deal Size : $128.0 million

                            Deal Type : Acquisition

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                            02

                            Apeiron Biologics

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                            Lead Product(s) : Alunacedase Alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            APEIRON Respiratory Therapies Announces Positive Results From Phase I Trial of Inhaled APN01

                            Details : The study met all primary and secondary endpoints, with all results indicating that the inhalation of APN01 (alunacedase alfa) at all dosage levels used in the trial is safe and well tolerated.

                            Brand Name : APN01

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 02, 2022

                            Lead Product(s) : Alunacedase Alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Apeiron Biologics

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                            Lead Product(s) : Alunacedase Alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Apeiron Biologics Begins Phase 1 Trial to Treat Covid-19 with Inhaled APN01

                            Details : Primary study objective is the evaluation of safety and tolerability of single ascending doses (SADs) and multiple ascending doses (MADs) of inhaled APN01 when administered via a jet nebulizer in healthy subjects.

                            Brand Name : APN01

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 12, 2021

                            Lead Product(s) : Alunacedase Alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Apeiron Biologics

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                            Lead Product(s) : BNC210

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Phase II

                            Recipient : Bionomics

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            $16 Million Capital Raise to Progress Bionomics BNC210 PTSD Trial

                            Details : Under the Subscription Agreement dated 2 June 2020 with Apeiron, Apeiron agreed to recapitalise the Company and assist in securing further equity capital to fund the Company's BNC210 Phase 2b Clinical trial for the treatment of post-traumatic stress diso...

                            Brand Name : BNC210

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            February 10, 2021

                            Lead Product(s) : BNC210

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Phase II

                            Recipient : Bionomics

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            05

                            Apeiron Biologics

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                            Lead Product(s) : SNS-301,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Recipient : Sensei Biotherapeutics

                            Deal Size : $30.0 million

                            Deal Type : Series B Financing

                            DEALS_DEV arrow-down

                            Sensei Biotherapeutics Announces $30 Million Financing to Advance Proprietary ImmunoPhage™ Platform and Onco...

                            Details : Sensei’s lead ImmunoPhage product candidate, SNS301, is being evaluated in a Phase 1/2 trial for the treatment of locally advanced unresectable or metastatic squamous cell carcinoma of the head and neck (SCCHN) in combination with pembrolizumab.

                            Brand Name : SNS-301

                            Molecule Type : Vaccine

                            Upfront Cash : Undisclosed

                            January 11, 2021

                            Lead Product(s) : SNS-301,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Recipient : Sensei Biotherapeutics

                            Deal Size : $30.0 million

                            Deal Type : Series B Financing

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                            06

                            Apeiron Biologics

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                            Apeiron Biologics

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                            Lead Product(s) : APN431

                            Therapeutic Area : Oncology

                            Study Phase : Discovery

                            Recipient : Domainex

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Expansion of APEIRON Biologics and Domainex Partnership will Advance Cancer Drug Discovery

                            Details : Domainex will provide its expertise in medicinal and computational chemistry, screening, structural biology and ADME/PK to advance APEIRON’s promising Cbl-b targeting compound series APN431 towards pre-clinical development.

                            Brand Name : APN431

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            November 09, 2020

                            Lead Product(s) : APN431

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery

                            Recipient : Domainex

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            07

                            Apeiron Biologics

                            Austria arrow
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                            Apeiron Biologics

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                            Lead Product(s) : Alunacedase alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            The Lancet Publishes Promising Data of Apeiron's APN01 (rhsACE2) to Treat COVID-19 in Named Patient Use

                            Details : Case study from promising first COVID-19 patient treatment with APN01 supports APEIRON’s ongoing pivotal Phase II clinical trial.

                            Brand Name : APN01

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 25, 2020

                            Lead Product(s) : Alunacedase alfa

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Apeiron Biologics

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                            Apeiron Biologics

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                            Lead Product(s) : APN401

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : MaxCyte

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            APEIRON Biologics and MaxCyte Enter Into Clinical and Commercial Licensing Agreement for APN401

                            Details : Under the terms of this licensing agreement, APEIRON to utilize MaxCyte's ExPERT® platform for siRNA-based cell therapy APN401 targeting solid tumors and secures manufacturing for upcoming clinical trials.

                            Brand Name : APN401

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            July 07, 2020

                            Lead Product(s) : APN401

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : MaxCyte

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            09

                            Apeiron Biologics

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                            Apeiron Biologics

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                            Lead Product(s) : APN01

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Apeiron Biologics gets regulatory approvals for Phase II Covid-19 trial

                            Details : Regulatory approvals obtained for the treatment of 200 COVID-19 patients in Austria, Germany and Denmark; Austrian government to provide significant financial support.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 02, 2020

                            Lead Product(s) : APN01

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Apeiron Biologics

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                            Lead Product(s) : APN01

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            APEIRON’s respiratory drug product to start pilot clinical trial to treat coronavirus disease COVID-19 in Ch...

                            Details : The randomized, unblinded trial will treat 24 patients for seven days to obtain preliminary data on the impact of rhACE2 on biological, physiologic, and clinical outcomes and safety in patients.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 26, 2020

                            Lead Product(s) : APN01

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Undisclosed

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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