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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Aspaveli (pegcetacoplan) is the first and only approved therapy for geographic atrophy. Now it is being evaluated for the treatment of C3 glomerulopathy & IC-MPGN.

                          Product Name : Aspaveli

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          February 20, 2025

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Nephrology

                          Highest Development Status : Phase III

                          Recipient : Swedish Orphan Biovitrum AB

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan) is the first and only approved therapy for geographic atrophy. It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Inapplicable

                          January 27, 2025

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan) is the first and only approved therapy for geographic atrophy. It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          September 20, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan injection) targets C3, being investigated for C3 glomerulopathy or primary immune complex membranoproliferative glomerulonephritis.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          August 08, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Swedish Orphan Biovitrum AB

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan) is the first and only approved therapy for geographic atrophy. It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          June 28, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan) is the first and only approved therapy for geographic atrophy. It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          June 10, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan) is the first and only approved therapy for geographic atrophy (GA). It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          April 26, 2024

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre (pegcetacoplan injection) is the first and only approved therapy for geographic atrophy (GA). It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          December 14, 2023

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Empaveli (pegcetacoplan) Injector is a compact, single-use, on-body device designed to enhance self-administration, which is indicated for treatment of adults with paroxysmal nocturnal hemoglobinuria (PNH).

                          Product Name : Empaveli

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          October 02, 2023

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          euroPLX 87
                          Not Confirmed
                          euroPLX 87
                          Not Confirmed

                          Details : Syfovre™ (pegcetacoplan injection) is the first and only approved therapy for geographic atrophy (GA). It targets C3 to provide comprehensive control of the complement cascade, part of the body’s immune system.

                          Product Name : Syfovre

                          Product Type : Peptide

                          Upfront Cash : Not Applicable

                          May 25, 2023

                          Lead Product(s) : Pegcetacoplan

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Swedish Orphan Biovitrum AB

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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