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    [{"orgOrder":0,"company":"Applied DNA Sciences Inc","sponsor":"Takis Biotech","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"ITALY","productType":"Vaccine","year":"2020","type":"Collaboration","leadProduct":"Linear DNA vaccine","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Applied DNA Sciences Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Applied DNA Sciences Inc \/ Applied DNA","highestDevelopmentStatusID":"4","companyTruncated":"Applied DNA Sciences Inc \/ Applied DNA"},{"orgOrder":0,"company":"Applied DNA Sciences Inc","sponsor":"Takis Biotech","pharmaFlowCategory":"D","therapeuticArea":"Infections and Infectious Diseases","country":"ITALY","productType":"Vaccine","year":"2020","type":"Collaboration","leadProduct":"Linear DNA vaccine","moa":"","graph1":"Infections and Infectious 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Vaccine","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"Applied DNA Sciences Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Applied DNA Sciences Inc \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"Applied DNA Sciences Inc \/ Not Applicable"},{"orgOrder":0,"company":"Applied DNA Sciences Inc","sponsor":"\u00daHKT","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"CAR123","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Applied DNA Sciences Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Applied DNA Sciences Inc \/ \u00daHKT","highestDevelopmentStatusID":"6","companyTruncated":"Applied DNA Sciences Inc \/ \u00daHKT"}]

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                            01

                            Applied DNA Sciences Inc

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                            Applied DNA Sciences Inc

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                            Lead Product(s) : CAR123

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : ÚHKT

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA Customer ÚHKT Initiates Phase I CAR T-Cell Therapy Trial with Linea DNA

                            Details : CAR123 an investigational CD123-specific autologous CAR T-cell therapy by the ÚHKT for the treatment of relapsed and/or refractory acute myeloid leukemia (AML).

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            December 18, 2024

                            Lead Product(s) : CAR123

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : ÚHKT

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Applied DNA Sciences Inc

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                            Lead Product(s) : DNA-based Covid-19 Vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA Announces Publication of Peer-Reviewed Journal Article Validating Potential Use of linearDNA™ as...

                            Details : The study demonstrated safety and immunogenicity of a linear DNA vaccine candidate against SARS-CoV-2 in a cohort of family-owned felines. Prime-boost vaccinations were administered by electro-gene-transfer intramuscularly to the cohort.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            January 05, 2023

                            Lead Product(s) : DNA-based Covid-19 Vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Applied DNA Sciences Inc

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                            Lead Product(s) : LinearDNA COVID-19 vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : EvviVax

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA, EvviVax, and GVS Receive Regulatory Approval to Conduct Veterinary Clinical Trial for Linear COVI...

                            Details : On the assumption that both trials’ primary endpoints are met, the Company and EvviVax expect to apply for a USDA APHIS conditional license (9 CFR 102.6) for a LinearDNA COVID-19 vaccine candidate for domestic felines.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            November 30, 2020

                            Lead Product(s) : LinearDNA COVID-19 vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : EvviVax

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Applied DNA Sciences Inc

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                            Applied DNA Sciences Inc

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                            Lead Product(s) : LineaDNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA and Takis Report Positive Preclinical Results from LineaDNA™ Vaccine Candidates for COVID-19

                            Details : BALB/c mice received linear DNA at day 1 and a booster vaccination on day 21. All animals demonstrated seroconversion to producing IgG against SARS-CoV-2 Spike Protein already by day 14, and significantly enhanced responses by day 38.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            July 17, 2020

                            Lead Product(s) : LineaDNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Applied DNA Sciences Inc

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                            PharmScience R&D
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                            Applied DNA Sciences Inc

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                            Lead Product(s) : LineaDNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA, Takis Announce Positive Preclinical Results from LineaDNA Vaccine Candidates for COVID-19

                            Details : All animals demonstrated seroconversion to producing IgG against SARS-CoV-2 Spike Protein already by day 14, and significantly enhanced responses by day 38.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            July 17, 2020

                            Lead Product(s) : LineaDNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Applied DNA Sciences Inc

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                            PharmScience R&D
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                            Applied DNA Sciences Inc

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                            Lead Product(s) : DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA and Takis Biotech Announce the Production of Neutralizing Antibodies Against SARS-CoV-2 After DNA ...

                            Details : First injections of the DNA vaccine candidates against the Spike protein of the SARS-CoV-2 virus have produced neutralizing antibodies that block the infection of cultured human cells by SARS-CoV-2.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            May 04, 2020

                            Lead Product(s) : DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Applied DNA Sciences Inc

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                            PharmScience R&D
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                            Applied DNA Sciences Inc

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                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA Ships COVID-19 LinearDNA™ Vaccine Candidates to Italian Development Partner to Begin Preclinical...

                            Details : Preliminary testing of plasmid-based vaccine templates shows strong immune responses, catalyzes testing of linear dna-based constructs set to begin immediately.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            April 15, 2020

                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Applied DNA Sciences Inc

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                            PharmScience R&D
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                            Applied DNA Sciences Inc

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                            Lead Product(s) : DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Discovery

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Applied DNA and Takis Biotech Expand COVID-19 Vaccine Development Program to Include 5th Candidate

                            Details : The newly added 5th linear DNA vaccine candidate encodes an engineered fusion protein of a COVID-19 Spike domain with an immunomodulator moiety.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Not Applicable

                            April 02, 2020

                            Lead Product(s) : DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Discovery

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Applied DNA Sciences Inc

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                            The Generic Rx Session
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                            Applied DNA Sciences Inc

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                            The Generic Rx Session
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                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Applied DNA Sciences Updates on COVID-19 Collaboration with Takis Biotech, 4 Preclinical LinearDNA™ Vaccine ...

                            Details : Applied DNA is expected to enter large-scale production of candidates in march; preclinical testing in animals by takis biotech anticipated to begin in calendar Q2 2020.

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            March 02, 2020

                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            10

                            Applied DNA Sciences Inc

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                            BioAsia
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                            Applied DNA Sciences Inc

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                            BioAsia
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                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Applied DNA and Takis Biotech partner on coronavirus vaccine

                            Details : LineaRx, a subsidiary of Applied DNA, will work with Takis Biotech on preclinical development of a linear DNA vaccine based on polymerase chain reaction (PCR).

                            Product Name : Undisclosed

                            Product Type : Vaccine

                            Upfront Cash : Undisclosed

                            February 10, 2020

                            Lead Product(s) : Linear DNA vaccine

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Preclinical

                            Recipient : Takis Biotech

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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