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Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Aprea Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Aprea Therapeutics","sponsor":"Karolinska Development AB","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"APR-548","moa":"p53","graph1":"Oncology","graph2":"IND Enabling","graph3":"Aprea Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Aprea Therapeutics \/ Karolinska Development AB","highestDevelopmentStatusID":"5","companyTruncated":"Aprea Therapeutics \/ Karolinska Development AB"},{"orgOrder":0,"company":"Aprea Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small 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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : APR-1051 is a highly selective and potentially best-in-class oral WEE1 inhibitor. It is being evaluated for HPV+ head and neck squamous cell carcinoma (HNSCC).

                          Product Name : APR-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 31, 2025

                          Lead Product(s) : APR-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : ATRN-119 is a potent and highly selective first-in-class macrocyclic ATR inhibitor, which is being evaluated for the treatment of DDR-mutated advanced solid tumors.

                          Product Name : ATRN-119

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : ATRN-119

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : APR-1051 is a next-generation WEE1 kinase inhibitor, which is being evaluated for the treatment of patients with cyclin E overexpressing breast and ovarian cancers.

                          Product Name : APR-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 03, 2024

                          Lead Product(s) : APR-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : Aprea intends to use the net proceeds to fund clinical development of APR-1051, the Company’s oral, small molecule, WEE1 inhibitor product candidate which recently received IND clearance.

                          Product Name : APR-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          November 03, 2024

                          Lead Product(s) : APR-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Maxim Group LLC

                          Deal Size : $34.0 million

                          Deal Type : Private Placement

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                          05

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : APR-1051 is a next-generation WEE1 kinase inhibitor, which is being evaluated for the treatment of patients with CCNE1 or CCNE2 overexpressing solid tumor.

                          Product Name : APR-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 17, 2024

                          Lead Product(s) : APR-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : APR-1051 is a next generation, oral WEE1 Kinase inhibitor. It's IND-application is submitted after preclinical studies for the treatment of cancers including ovarian cancer.

                          Product Name : APR-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 02, 2024

                          Lead Product(s) : APR-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : ATRN-119 is the first and only macrocyclic small molecule ATR inhibitor in the clinic, in development as monotherapy in patients with advanced solid tumors harboring defined mutations in DDR pathways.

                          Product Name : ATRN-119

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 28, 2024

                          Lead Product(s) : ATRN-119

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : ATRN-1051 is an orally bioavailable small molecule inhibitor of WEE1 that is highly potent and selective, which is investigated for treatment of ovarian cancer.

                          Product Name : ATRN-1051

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 09, 2023

                          Lead Product(s) : ATRN-1051

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : ATRN-119 is an ATR inhibitor for the treatment of cancers with DDR mutations. It has demonstrated potent anti-proliferative activity against a variety of cancer cell lines, inhibited tumor growth in genetically defined ovarian, colon, pancreatic etc.

                          Product Name : ATRN-119

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          November 01, 2023

                          Lead Product(s) : ATRN-119

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          WRIB
                          Not Confirmed
                          WRIB
                          Not Confirmed

                          Details : The net proceeds received from the public offering will enable the Company to continue developing its clinical asset, ATRN-119, its pre-clinical asset ATRN-W1051 and for general corporate purposes.

                          Product Name : ATRN-119

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          February 27, 2023

                          Lead Product(s) : ATRN-119

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Maxim Group LLC

                          Deal Size : $5.5 million

                          Deal Type : Public Offering

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