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Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Aptevo Therapeutics \/ Piper Sandler","highestDevelopmentStatusID":"15","companyTruncated":"Aptevo Therapeutics \/ Piper Sandler"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Midcap Financial Trust","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Financing","leadProduct":"Azacitidine","moa":"||CD3","graph1":"Oncology","graph2":"Phase I","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Midcap Financial Trust","highestDevelopmentStatusID":"6","companyTruncated":"Aptevo Therapeutics \/ Midcap Financial Trust"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Alliance Global Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2023","type":"Public Offering","leadProduct":"Azacitidine","moa":"||CD3","graph1":"Oncology","graph2":"Phase I","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Alliance Global Partners","highestDevelopmentStatusID":"6","companyTruncated":"Aptevo Therapeutics \/ Alliance Global Partners"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Roth Capital Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2024","type":"Public Offering","leadProduct":"Mipletamig","moa":"CD3","graph1":"Oncology","graph2":"Phase I","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2024","type":"Public Offering","leadProduct":"Mipletamig","moa":"CD3","graph1":"Oncology","graph2":"Phase I","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Roth Capital Partners","highestDevelopmentStatusID":"6","companyTruncated":"Aptevo Therapeutics \/ Roth Capital Partners"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Roth Capital Partners","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2024","type":"Public Offering","leadProduct":"Mipletamig","moa":"CD3","graph1":"Oncology","graph2":"Phase I","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2020","type":"Acquisition","leadProduct":"Recombinant Coagulation Factor Ix","moa":"Factor IX","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Medexus Pharmaceuticals","highestDevelopmentStatusID":"15","companyTruncated":"Aptevo Therapeutics \/ Medexus Pharmaceuticals"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"XOMA","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Protein","year":"2023","type":"Agreement","leadProduct":"Recombinant Coagulation Factor Ix","moa":"Factor IX","graph1":"Genetic Disease","graph2":"Approved FDF","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ XOMA","highestDevelopmentStatusID":"15","companyTruncated":"Aptevo Therapeutics \/ XOMA"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Pfizer Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2020","type":"Agreement","leadProduct":"Rituximab","moa":"CD20","graph1":"Oncology","graph2":"Approved FDF","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Aptevo Therapeutics \/ Pfizer Inc","highestDevelopmentStatusID":"15","companyTruncated":"Aptevo Therapeutics \/ Pfizer Inc"},{"orgOrder":0,"company":"Aptevo 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I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Aptevo Therapeutics \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : APVO436 (mipletamig) is a CD3/123 bispefic antibody, currently being evaluated for the treatment of Acute Myeloid Leukemia, in combination with venetoclax and azacitidine.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 12, 2024

                          Lead Product(s) : Mipletamig,Azacitidine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : APVO436 (mipletamig) is a CD3/123 bispefic antibody, currently being evaluated for the treatment of Acute Myeloid Leukemia, in combination with venetoclax and azacitidine.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          November 20, 2024

                          Lead Product(s) : Mipletamig,Azacitidine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The company intends to use the net proceeds from the offering for the continued clinical development of its product candidate APVO436 for the treatment of acute myeloid leukemia.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          November 04, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $4.6 million

                          Deal Type : Public Offering

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                          04

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : ALG.APV-527 is a bispecific antibody targeting the 4-1BB receptor on immune cells, being evaluated for solid tumors in the ADAPTIR™ format with a silenced IgG1 Fc domain.

                          Product Name : ALG.APV-527

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 04, 2024

                          Lead Product(s) : ALG.APV-527

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Alligator Bioscience

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The net proceeds will fund the clinical development of the company's lead product APVO436, which is being evaluated in the early stage trial for the treatment of Acute myeloid leukemia.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          September 18, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $3.0 million

                          Deal Type : Public Offering

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                          06

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The net proceeds will fund the clinical development of the company's lead product APVO436, which is being evaluated in the early stage trial for the treatment of Acute myeloid leukemia.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          September 16, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $3.0 million

                          Deal Type : Public Offering

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                          07

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : ALG.APV-527 is a human bispecific antibody with a silenced IgG1 Fc domain targeting the co-stimulatory receptor 4-1BB. It is being evaluated for the treatment of solid tumors.

                          Product Name : ALG.APV-527

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          September 16, 2024

                          Lead Product(s) : ALG.APV-527

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Alligator Bioscience

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The net proceeds will be used for the development of APVO436, a recombinant T cell-engaging humanized bispecific antibody, for relapsed or refractory AML.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          June 28, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $2.7 million

                          Deal Type : Public Offering

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                          09

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : The company intends to use the net proceeds from the offering to advance the clinical development of its product candidate APVO436 for treating acute myeloid leukemia.

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          April 15, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $4.6 million

                          Deal Type : Public Offering

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                          10

                          Interphex
                          Not Confirmed
                          Interphex
                          Not Confirmed

                          Details : APVO436 is a bispecific CD3xCD123 ADAPTIR drug candidate. The Company previously reported positive Phase 1b expansion trial results in AML and is planning to initiate Phase 2 trials in relapsed/refractory and frontline patients in 2H23 and 1H24 respectiv...

                          Product Name : APVO436

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          July 18, 2023

                          Lead Product(s) : Mipletamig,Azacitidine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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