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Applicable"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Medexus Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Acquisition","leadProduct":"Recombinant coagulation factor IX","moa":"Factor IX","graph1":"Genetic Disease","graph2":"Approved","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Aptevo Therapeutics \/ Medexus","highestDevelopmentStatusID":"12","companyTruncated":"Aptevo Therapeutics \/ Medexus"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Pfizer Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Agreement","leadProduct":"Rituximab","moa":"CD20","graph1":"Oncology","graph2":"Approved","graph3":"Aptevo Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"Aptevo Therapeutics \/ Pfizer Inc","highestDevelopmentStatusID":"12","companyTruncated":"Aptevo Therapeutics \/ Pfizer Inc"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"Piper Sandler","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Divestment","leadProduct":"Rituximab","moa":"CD20","graph1":"Oncology","graph2":"Approved","graph3":"Aptevo Therapeutics","amount2":0.01,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0.01,"dosageForm":"","sponsorNew":"Aptevo Therapeutics \/ Piper Sandler","highestDevelopmentStatusID":"12","companyTruncated":"Aptevo Therapeutics \/ Piper Sandler"},{"orgOrder":0,"company":"Aptevo Therapeutics","sponsor":"MidCap Financial 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Find Clinical Drug Pipeline Developments & Deals by Aptevo Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : APVO436 (mipletamig) is a CD3/123 bispefic antibody, currently being evaluated for the treatment of Acute Myeloid Leukemia, in combination with venetoclax and azacitidine.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 20, 2024

                          Lead Product(s) : Mipletamig,Venetoclax,Azacitidine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The net proceeds will fund the clinical development of the company's lead product APVO436, which is being evaluated in the early stage trial for the treatment of Acute myeloid leukemia.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 18, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $3.0 million

                          Deal Type : Public Offering

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The net proceeds will fund the clinical development of the company's lead product APVO436, which is being evaluated in the early stage trial for the treatment of Acute myeloid leukemia.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 16, 2024

                          Lead Product(s) : Mipletamig

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $3.0 million

                          Deal Type : Public Offering

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALG.APV-527 is a human bispecific antibody with a silenced IgG1 Fc domain targeting the co-stimulatory receptor 4-1BB. It is being evaluated for the treatment of solid tumors.

                          Brand Name : ALG.APV-527

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          September 16, 2024

                          Lead Product(s) : ALG.APV-527

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Alligator Bioscience

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The net proceeds will be used for the development of APVO436, a recombinant T cell-engaging humanized bispecific antibody, for relapsed or refractory AML.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          June 28, 2024

                          Lead Product(s) : APVO436

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $2.7 million

                          Deal Type : Public Offering

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The company intends to use the net proceeds from the offering to advance the clinical development of its product candidate APVO436 for treating acute myeloid leukemia.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 15, 2024

                          Lead Product(s) : APVO436

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $4.6 million

                          Deal Type : Public Offering

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The company intends to use the net proceeds from the offering for the continued clinical development of its product candidate APVO436 for the treatment of acute myeloid leukemia.

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          April 11, 2024

                          Lead Product(s) : APVO436

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Roth Capital Partners

                          Deal Size : $4.6 million

                          Deal Type : Public Offering

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ALG.APV-527 is a bispecific antibody targeting the 4-1BB receptor on immune cells, being evaluated for solid tumors in the ADAPTIR™ format with a silenced IgG1 Fc domain.

                          Brand Name : ALG.APV-527

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          April 10, 2024

                          Lead Product(s) : ALG.APV-527

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Alligator Bioscience

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The Company intends to use the net proceeds for the continued clinical development of its product candidates including

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 04, 2023

                          Lead Product(s) : APVO436

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Alliance Global Partners

                          Deal Size : $5.0 million

                          Deal Type : Public Offering

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : APVO436 is a bispecific CD3xCD123 ADAPTIR drug candidate. The Company previously reported positive Phase 1b expansion trial results in AML and is planning to initiate Phase 2 trials in relapsed/refractory and frontline patients in 2H23 and 1H24 respectiv...

                          Brand Name : APVO436

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 18, 2023

                          Lead Product(s) : APVO436

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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