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    [{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"CANADA","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"CG-806","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Aptose Biosciences","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Aptose Biosciences \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Aptose Biosciences \/ Not Applicable"},{"orgOrder":0,"company":"Aptose Biosciences","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"CG-806","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Aptose Biosciences","amount2":0,"highestDevelopmentShortName":"Ph 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                            01

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Financing

                            DEALS_DEV arrow-down

                            Aptose Receives $10M and Negotiates Partnership with Hanmi For Tuspetinib

                            Details : Aptose will use the proceeds from such loan for the development of HM43239 (tuspetinib), a highly differentiated oral kinase inhibitor for the treatment of patients with acute myeloid leukemia (AML).

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            August 30, 2024

                            Lead Product(s) : Tuspetinib,Azacitidine,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : Undisclosed

                            Deal Type : Financing

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                            02

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $13.7 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aptose Closes $9.7 Mn Offering and $4 Mn Private Placement with Hanmi Pharmaceutical

                            Details : The net proceeds will be used for the manufacturing and clinical trials of potent inhibitor known as HM43239 (tuspetinib) for patients with relapsed or refractory acute myeloid leukemia (AML).

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            January 31, 2024

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $13.7 million

                            Deal Type : Public Offering

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                            03

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Newbridge Securities Corporation

                            Deal Size : $8.4 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Aptose Announces Pricing Of $8.4 Million Public Offering and $4 Million Placement

                            Details : The net proceeds to support clinical trials for HM43239, a daily oral therapy being studied as monotherapy and in combination therapy for relapsed or refractory acute myeloid leukemia.

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            January 26, 2024

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Newbridge Securities Corporation

                            Deal Size : $8.4 million

                            Deal Type : Public Offering

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                            04

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Aptose Announces Closing of $3 Million Investment by Hanmi Pharmaceutical

                            Details : The proceeds will be used for Aptose’s lead hematology drug, tuspetinib, formerly HM43239, an orally active small molecule inhibitor of FLT3, currently in Phase 1/2 trial in which patients with R/R AML receive tuspetinib monotherapy or in combination w...

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 06, 2023

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Hanmi Pharmaceutical

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

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                            05

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aptose Initiates Dosing of Tuspetinib in APTIVATE Expansion Trial in Patients with Acute Myeloid Leukemia

                            Details : HM43239 (tuspetinib), once daily oral agent which inhibts SYK, JAK1/2, FLT3, and other kinases operative in AML, by inhibiting tyrosine kinase, tucatinib exerts anti-tumor activity, reducing the size of HER-2 positive breast cancer tumors.

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 30, 2023

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aptose Announces Updated Clinical Responses, Breadth of Activity, and Safety Across Four Dose Levels of Tuspet...

                            Details : HM43239 (tuspetinib), a once daily oral agent designed to target FLT3, SYK, and JAK kinases but avoid targets that drive toxicities, safely delivered complete remissions as a monotherapy across four dose levels (40mg, 80mg, 120mg, and 160mg) in acute mye...

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 11, 2022

                            Lead Product(s) : Tuspetinib,Venetoclax

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Aptose Biosciences

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                            Lead Product(s) : Tuspetinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aptose Receives Fast Track Designation for HM43239 in Relapsed/Refractory AML Patients and FLT3 Mutation

                            Details : HM43239 is a potent oral genotype-agnostic small molecule inhibitor of a constellation of kinases operative in myeloid malignancies and known to be involved in tumor proliferation, resistance to therapy, and differentiation.

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 04, 2022

                            Lead Product(s) : Tuspetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Aptose Biosciences

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                            Lead Product(s) : Luxeptinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Luxeptinib Preclinical Data Extend Potential Applications from Oncology to Inflammation

                            Details : CG-806 (luxeptinib) is an orally bioavailable kinase inhibitor with potency against select kinases including BTK, inhibits NLRP3 inflammasome function in THP-1 monocytes and bone marrow-derived macrophages.

                            Brand Name : CG-806

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 02, 2022

                            Lead Product(s) : Luxeptinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Aptose Biosciences

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                            Lead Product(s) : APTO-253

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Aptose Provides Update on APTO-253 Program

                            Details : APTO-253 remains an interesting product that has demonstrated MYC repression, which creates optionality across the wider oncology spectrum. Clinical development of the MYC repressor APTO-253 will be discontinued.

                            Brand Name : APTO-253

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 20, 2021

                            Lead Product(s) : APTO-253

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Tuspetinib

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            HM43239 Demonstrates Durable Clinical Benefit in Acute Myeloid Leukemia

                            Details : In earlier preclinical studies, HM43239 demonstrated potent in vitro and in vivo activity against FLT3 ITD mutated as well as resistance-conferring D835 and gatekeeper (F691) TKD mutated AML.

                            Brand Name : HM43239

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 13, 2021

                            Lead Product(s) : Tuspetinib

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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