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Inc"},{"orgOrder":0,"company":"Arbor Biotechnologies, Inc","sponsor":"Allogene Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Licensing Agreement","leadProduct":"ALLO-329","moa":"","graph1":"Immunology","graph2":"IND Enabling","graph3":"Arbor Biotechnologies, Inc","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Immunology","amount2New":0,"dosageForm":"","sponsorNew":"Arbor Biotechnologies, Inc \/ Allogene Therapeutics","highestDevelopmentStatusID":"5","companyTruncated":"Arbor Biotechnologies, Inc \/ Allogene Therapeutics"},{"orgOrder":0,"company":"Arbor Biotechnologies, Inc","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"ABO-101","moa":"","graph1":"Genetic Disease","graph2":"Phase I","graph3":"Arbor Biotechnologies, Inc","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"Arbor Biotechnologies, Inc \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"Arbor Biotechnologies, Inc \/ Not Applicable"}]

Find Clinical Drug Pipeline Developments & Deals by Arbor Biotechnologies, Inc

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                          Therapeutic Area by Lead Product

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                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : ABO-101, a novel gene editing therapeutic, is currently being evaluated in phase 1 clinical trials. It is designed to treat patients suffering from primary hyperoxaluria type 1.

                          Brand Name : ABO-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 09, 2024

                          Lead Product(s) : ABO-101

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Under the agreement, Allogene will use Arbor’s proprietary CRISPR gene-editing technology in its next generation AlloCAR T platform, ALLO-329, for the treatment of autoimmune disease (AID).

                          Brand Name : ALLO-329

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 12, 2024

                          Lead Product(s) : ALLO-329

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : Allogene Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : 4DMT and Arbor will co-develop and co-commercialize up to six AAV-delivered CRISPR/Cas-based therapeutic candidates for central nervous system diseases, including amyotrophic lateral sclerosis.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 03, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Preclinical

                          Recipient : 4D Molecular Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          04

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Under the terms of the agreement, Vertex Pharmaceuticals incorporated will receive rights to Arbor’s novel precision editing technology for up to three diseases.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 11, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Discovery

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : $1,200.0 million

                          Deal Type : Expanded Collaboration

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                          05

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : As part of the agreement, the companies will combine the optimized delivery of Acuitas' highly validated LNP technology with Arbor’s differentiated, proprietary CRISPR gene editing technology designed for use in vivo in patients with rare liver disease...

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 25, 2022

                          Lead Product(s) : LNP-based Gene Therapy

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Undisclosed

                          Sponsor : Acuitas

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The collaboration leverages Arbor’s proprietary CRISPR gene-editing technology and TCR 2’s’ TRuC platform, which has demonstrated clinical activity in multiple treatment-refractory mesothelin-expressing solid tumor indications with its lead autolog...

                          Brand Name : Gavo-cel

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          January 04, 2022

                          Lead Product(s) : Gavocabtagene autoleucel,Fludarabine Phosphate,Cyclophosphamide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : TCR2 Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Arbor plans to use the proceeds to advance its lead programs in liver and CNS disease into the clinic and progress a pipeline of precision editing therapeutics, while continuing to invest in its novel discovery engine to develop the next generation of ge...

                          Brand Name : Undisclosed

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          November 09, 2021

                          Lead Product(s) : Nuclease Therapies

                          Therapeutic Area : Hepatology (Liver, Pancreatic, Gall Bladder)

                          Highest Development Status : Discovery

                          Sponsor : Temasek Life Sciences Laboratory

                          Deal Size : $215.0 million

                          Deal Type : Series B Financing

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                          08

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Under this new partnership, Vertex will receive rights to use Arbor’s technology to research and develop ex vivo engineered cell therapies towards Vertex’s goal of generating fully differentiated, insulin-producing hypoimmune islet cells for the trea...

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          August 24, 2021

                          Lead Product(s) : Ex-vivo Engineered Cell Therapies

                          Therapeutic Area : Endocrinology

                          Highest Development Status : Discovery Platform

                          Sponsor : Vertex Pharmaceuticals

                          Deal Size : $1,200.0 million

                          Deal Type : Collaboration

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                          09

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The agreement aims to utilize Arbor’s gene editing technologies to engineer hematopoietic stem cells, towards the goal of developing therapies for the treatment of blood cancers, such as acute myeloid leukemia.

                          Brand Name : VOR33

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          September 29, 2020

                          Lead Product(s) : Engineered hematopoietic stem cell

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Vor Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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