Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : ACLX-001
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Kite Pharma
Deal Size : $285.0 million
Deal Type : Expanded Collaboration
Arcellx and Kite Announce Expansion in Strategic Partnership
Details : Under the expanded collaboration, Kite has exercised its option to negotiate a license for Arcellx's ARC-SparX program, ACLX-001, in multiple myeloma, which is comprised of ARC-T cells and SparX proteins that target BCMA.
Brand Name : ACLX-001
Molecule Type : Cell and Gene therapy
Upfront Cash : $85.0 million
November 15, 2023
Lead Product(s) : ACLX-001
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Kite Pharma
Deal Size : $285.0 million
Deal Type : Expanded Collaboration
Details : CART-ddBCMA is Arcellx's BCMA-specific CAR-modified T-cell therapy utilizing the company's novel BCMA-targeting binding domain for the treatment of patients with relapsed or refractory multiple myeloma.
Brand Name : CART-ddBCMA
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
August 14, 2023
Arcellx Announces Clinical Hold for Its IMMagine-1 Phase 2 Clinical Program
Details : CART-ddBCMA is Arcellx's BCMA-specific CAR-modified T-cell therapy utilizing the company's novel BCMA-targeting binding domain for the treatment of patients with relapsed or refractory multiple myeloma.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 19, 2023
Lead Product(s) : CART-ddBCMA
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Kite Pharma
Deal Size : $325.0 million
Deal Type : Termination
Details : Kite and Arcellx were jointly working to advance and commercialize the CART-ddBCMA asset for relapsed or refractory multiple myeloma in U.S., and Kite was supposed to commercialize outside the U.S.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : $225.0 million
January 30, 2023
Lead Product(s) : CART-ddBCMA
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Kite Pharma
Deal Size : $325.0 million
Deal Type : Termination
Lead Product(s) : CART-ddBCMA
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Kite Pharma
Deal Size : $4225.0 million
Deal Type : Collaboration
Details : CART-ddBCMA is an investigational cell therapy product comprising autologous T cells that have been genetically modified to target multiple myeloma. CART-ddBCMA utilizes Arcellx’s novel D-Domain binder.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : $225.0 million
December 09, 2022
Lead Product(s) : CART-ddBCMA
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Kite Pharma
Deal Size : $4225.0 million
Deal Type : Collaboration
Details : ACLX-001, ARC-SparX is a novel CAR-T cell therapy treatment designed to allow for controllability and adaptability to potentially reduce toxicities associated with serious dose-limiting adverse events and overcome tumor heterogeneity.
Brand Name : ACLX-001
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 10, 2022
Details : The proceeds will support the company’s development of CART-ddBCMA, a BCMA-specific CAR-modified T-cell therapy currently in Phase 1 and anticipated to begin a pivotal trial in 2022.
Brand Name : CART-ddBCMA
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
April 13, 2021
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