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Find Clinical Drug Pipeline Developments & Deals by Arcellx

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Under the expanded collaboration, Kite has exercised its option to negotiate a license for Arcellx's ARC-SparX program, ACLX-001, in multiple myeloma, which is comprised of ARC-T cells and SparX proteins that target BCMA.

                          Brand Name : ACLX-001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $85.0 million

                          November 15, 2023

                          Lead Product(s) : ACLX-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Kite Pharma

                          Deal Size : $285.0 million

                          Deal Type : Expanded Collaboration

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CART-ddBCMA is Arcellx's BCMA-specific CAR-modified T-cell therapy utilizing the company's novel BCMA-targeting binding domain for the treatment of patients with relapsed or refractory multiple myeloma.

                          Brand Name : CART-ddBCMA

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 14, 2023

                          Lead Product(s) : CART-ddBCMA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CART-ddBCMA is Arcellx's BCMA-specific CAR-modified T-cell therapy utilizing the company's novel BCMA-targeting binding domain for the treatment of patients with relapsed or refractory multiple myeloma.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 19, 2023

                          Lead Product(s) : CART-ddBCMA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Kite and Arcellx were jointly working to advance and commercialize the CART-ddBCMA asset for relapsed or refractory multiple myeloma in U.S., and Kite was supposed to commercialize outside the U.S.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $225.0 million

                          January 30, 2023

                          Lead Product(s) : CART-ddBCMA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Kite Pharma

                          Deal Size : $325.0 million

                          Deal Type : Termination

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : CART-ddBCMA is an investigational cell therapy product comprising autologous T cells that have been genetically modified to target multiple myeloma. CART-ddBCMA utilizes Arcellx’s novel D-Domain binder.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $225.0 million

                          December 09, 2022

                          Lead Product(s) : CART-ddBCMA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Kite Pharma

                          Deal Size : $4225.0 million

                          Deal Type : Collaboration

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : ACLX-001, ARC-SparX is a novel CAR-T cell therapy treatment designed to allow for controllability and adaptability to potentially reduce toxicities associated with serious dose-limiting adverse events and overcome tumor heterogeneity.

                          Brand Name : ACLX-001

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 10, 2022

                          Lead Product(s) : ACLX-001

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : The proceeds will support the company’s development of CART-ddBCMA, a BCMA-specific CAR-modified T-cell therapy currently in Phase 1 and anticipated to begin a pivotal trial in 2022.

                          Brand Name : CART-ddBCMA

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          April 13, 2021

                          Lead Product(s) : CART-ddBCMA

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Samsara BioCapital

                          Deal Size : $115.0 million

                          Deal Type : Series C Financing

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