[{"orgOrder":0,"company":"Arctic Vision","sponsor":"Loyal Valley Capital","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2021","type":"Series B Financing","leadProduct":"Triamcinolone Acetonide","moa":"Glucocorticoid receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Arctic Vision","amount2":0.10000000000000001,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0.10000000000000001,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Arctic Vision \/ Loyal Valley Capital","highestDevelopmentStatusID":"10","companyTruncated":"Arctic Vision \/ Loyal Valley Capital"},{"orgOrder":0,"company":"Arctic Vision","sponsor":"ActualEyes","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Licensing Agreement","leadProduct":"Rho-associated kinase-Human corneal endothelial 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Kong"},{"orgOrder":0,"company":"Arctic Vision","sponsor":"Clearside Biomedical","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2021","type":"Licensing Agreement","leadProduct":"Triamcinolone Acetonide","moa":"Glucocorticoid receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Arctic Vision","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Suprachoroidal Injection","sponsorNew":"Arctic Vision \/ Clearside Biomedical","highestDevelopmentStatusID":"10","companyTruncated":"Arctic Vision \/ Clearside Biomedical"},{"orgOrder":0,"company":"Arctic Vision","sponsor":"Clearside Biomedical","pharmaFlowCategory":"D","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2021","type":"Licensing Agreement","leadProduct":"Triamcinolone Acetonide","moa":"Glucocorticoid 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Eyenovia"},{"orgOrder":0,"company":"Arctic Vision","sponsor":"Eyenovia","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Pilocarpine Hydrochloride","moa":"Muscarinic M3 receptor","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Arctic Vision","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Solution","sponsorNew":"Arctic Vision \/ Eyenovia","highestDevelopmentStatusID":"10","companyTruncated":"Arctic Vision \/ Eyenovia"},{"orgOrder":0,"company":"Arctic Vision","sponsor":"Clearside Biomedical","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Triamcinolone Acetonide","moa":"","graph1":"Ophthalmology","graph2":"Approved","graph3":"Arctic 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Find Clinical Drug Pipeline Developments & Deals by Arctic Vision

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                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Under the agreement, Arctic Vision has granted the rights of Arcatus (triamcinolone acetonide injectable suspension) to Santen to commercialize in China for macular edema associated with uveitis.

                          Brand Name : Arcatus

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 07, 2024

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Clearside Biomedical

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          02

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Arcatus is a proprietary suspension of the corticosteroid triamcinolone acetonide for administration to the suprachoroidal space for the treatment of macular edema associated with uveitis.

                          Brand Name : Arcatus

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 29, 2024

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Clearside Biomedical

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Arcatus is a proprietary suspension of the corticosteroid triamcinolone acetonide for administration to the suprachoroidal space for the treatment of macular edema associated with uveitis and is referred as Xipere, approved in United States.

                          Brand Name : Arcatus

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 10, 2023

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Clearside Biomedical

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : ARVN003 (pilocarpine microdose ophthalmic solution/Microline), a proprietary formulation based on microdosing platform Optejet® for the pharmacologic treatment for presbyopia.

                          Brand Name : MicroLine

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 06, 2022

                          Lead Product(s) : Pilocarpine Hydrochloride

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Eyenovia

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : XIPERE, referred to as ARVN001 by Arctic Vision, is a proprietary suspension of the corticosteroid triamcinolone acetonide formulated for administration to the suprachoroidal space (SCS®) using Clearside’s patented SCS Microinjector®.

                          Brand Name : Xipere

                          Molecule Type : Small molecule

                          Upfront Cash : $3.0 million

                          September 09, 2021

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Recipient : Clearside Biomedical

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          06

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : ARVN003 is a pharmacologic treatment for presbyopia. The product is developed based on Optejet, a proprietary micro-dosing administration device utilizing MAP technology, and pilocapine, the well-established ophthalmic medicine for temporary improvement ...

                          Brand Name : MicroLine

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 03, 2021

                          Lead Product(s) : Pilocarpine Hydrochloride

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Eyenovia

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : ARVN001 is a proprietary suspension of the corticosteroid triamcinolone acetonide formulated for administration to the suprachoroidal space (SCS®) through Clearside’s patented SCS Microinjector®.

                          Brand Name : Xipere

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 15, 2021

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Clearside Biomedical

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          08

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : ARVN601 Neuroprotection, in the form of non-IOP-related interventions to prevent or delay glaucomatous neurodegeneration, has been underscored to be an unmet need in the management of glaucoma ever since the 2010 World Glaucoma Association Consensus Meet...

                          Brand Name : ARVN601

                          Molecule Type : Undisclosed

                          Upfront Cash : Undisclosed

                          July 05, 2021

                          Lead Product(s) : ARVN601

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Sponsor : University of Hong Kong

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          09

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Arctic Vision will develop and market ActualEyes’ AE-101, for the treatment of corneal endothelial dysfunction in Greater China and South Korea. ARVN901 (AE-101) is a novel cell-injection therapy developed using cultured hCECs combined with a ROCK inhi...

                          Brand Name : AE101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          May 14, 2021

                          Lead Product(s) : Rho-associated kinase-Human corneal endothelial cells

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Preclinical

                          Recipient : ActualEyes

                          Deal Size : $35.0 million

                          Deal Type : Licensing Agreement

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                          10

                          Pharmtech & Ingredients
                          Not Confirmed
                          Pharmtech & Ingredients
                          Not Confirmed

                          Details : Arctic Vision currently has three late-stage in-licensed products: ARVN001 for uveitic macular edema (UME), ARVN002 for pediatric progressive myopia and ARVN003 for presbyopia.

                          Brand Name : ARVN001

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 10, 2021

                          Lead Product(s) : Triamcinolone Acetonide

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Loyal Valley Capital

                          Deal Size : $100.0 million

                          Deal Type : Series B Financing

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