[{"orgOrder":0,"company":"AriBio","sponsor":"SK Chemicals","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"CREB pathway","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ SK Chemicals","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ SK Chemicals"},{"orgOrder":0,"company":"AriBio","sponsor":"Cleveland Clinic","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"PDE5","graph1":"Neurology","graph2":"Phase II","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Cleveland Clinic Genomic Medicine Institute","highestDevelopmentStatusID":"8","companyTruncated":"AriBio \/ Cleveland Clinic Genomic Medicine Institute"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"PDE5","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Undisclosed","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Agreement","leadProduct":"Mirodenafil","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0.77000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0.77000000000000002,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Undisclosed","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Undisclosed"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Mirodenafil dihydrochloride","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Mirodenafil dihydrochloride","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"","sponsorNew":"AriBio \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"AriBio \/ Not Applicable"},{"orgOrder":0,"company":"AriBio","sponsor":"Adaptive Research","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Methylbenzylamine","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AriBio","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AriBio \/ Adaptive Research","highestDevelopmentStatusID":"14","companyTruncated":"AriBio \/ Adaptive Research"}]

Find Clinical Drug Pipeline Developments & Deals by AriBio

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 is a phosphodiesterase-5 (PDE5) inhibitor being developed as an oral agent for the treatment of early Alzheimer’s disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 30, 2024

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Adaptive Research

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 is a phosphodiesterase-5 (PDE5) inhibitor being developed as an investigational oral agent being investigated for the treatment of early Alzheimer’s disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 14, 2024

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 is a phosphodiesterase-5 (PDE5) inhibitor being developed as an investigational oral agent being investigated for the treatment of early Alzheimer’s disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 28, 2024

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AriBio has concluded an exclusive distribution agreement with a Chinese pharmaceutical company for AR1001 (mirodenafil), an oral PDE5 inhibitor, for the treatment for Alzheimer's disease, in China.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : $90.0 million

                          March 24, 2024

                          Lead Product(s) : Mirodenafil

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Undisclosed

                          Deal Size : $770.0 million

                          Deal Type : Agreement

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                          05

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 (mirodenafil dihydrochloride) is an oral PDE5 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of patients with Alzheimer's Disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 25, 2024

                          Lead Product(s) : Mirodenafil dihydrochloride

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 is an oral PDE5 inhibitor, small molecule drug candidate. It is being evaluated for the treatment of patients with Alzheimer's Disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 14, 2023

                          Lead Product(s) : Mirodenafil dihydrochloride

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AR1001 is a blood-brain barrier penetrating small molecule known to inhibit neuron apoptosis and promote neurogenesis, increase neuroplasticity and increase autophagy activity to remove toxic proteins.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 05, 2023

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Pre-clinical studies have confirmed neuroprotective effects of AR1001 via inhibiting neuron apoptosis and restoring synaptic plasticity, also has demonstrated notable effects against amyloid plaques and tau proteins via autophagy activation.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 04, 2022

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : Positive Phase II trial reported for AR1001, the results confirmed the possibility of developing a unique oral disease-modifying treatment for AD that improves cognitive function. The Company will complete Phase III clinical trials of AR1001 within the n...

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          December 20, 2021

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Cleveland Clinic

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Fi Europe 2024
                          Not Confirmed
                          Fi Europe 2024
                          Not Confirmed

                          Details : AriBio completed enrollment in a Phase 2 study of AR1001, a first in class, orally dosed investigational drug for mild to moderate Alzheimer’s disease.

                          Brand Name : AR1001

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 17, 2020

                          Lead Product(s) : Methylbenzylamine

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : SK Chemicals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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