Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AR-301 (tosatoxumab) is a fully human IgG1 monoclonal antibody that specifically targets S. aureus alpha-toxin, an important virulence factor that is secreted by both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus being deve...
Brand Name : AR-301
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 17, 2023
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AR-301 (tosatoxumab), a fully human IgG1 monoclonal antibody that specifically targets S. aureus alpha-toxin, an important virulence factor that is secreted by both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus, is being de...
Brand Name : AR-301
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 12, 2023
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AR-301 (tosatoxumab) is a fully human IgG1 monoclonal antibody that specifically targets S. aureus alpha-toxin, an important virulence factor that is secreted by both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus being deve...
Brand Name : AR-301
Molecule Type : Large molecule
Upfront Cash : Not Applicable
June 20, 2023
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AR-301 (tosatoxumab) is a fully human IgG1 monoclonal antibody that specifically targets S. aureus alpha-toxin, an important virulence factor that is secreted by both methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus being deve...
Brand Name : AR-301
Molecule Type : Large molecule
Upfront Cash : Not Applicable
May 31, 2023
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Suvratoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : AstraZeneca
Deal Size : $126.0 million
Deal Type : Termination
AstraZeneca Pulls Pneumonia Collab With Aridis Over Allegations Of A Missed Payment
Details : AstraZeneca terminated the collaboration with Aridis for the licensing of the AR-320 (suvratoxumab), a fully human, half-life extended IgG1 monoclonal antibody targeting S. aureus alpha toxin.
Brand Name : AR-320
Molecule Type : Large molecule
Upfront Cash : $11.0 million
March 31, 2023
Lead Product(s) : Suvratoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : AstraZeneca
Deal Size : $126.0 million
Deal Type : Termination
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Aridis Meets Primary and Secondary Endpoints in Phase 2a Study of AR-501 in Cystic Fibrosis Patients
Details : AR-501 is a novel inhaled formulation of gallium citrate with broad-spectrum anti-infective activity involving iron acquisition and metabolism, is being developed to treat chronic lung infections in cystic fibrosis (CF) patients.
Brand Name : AR-501
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 13, 2023
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AR-301 is a fully human IgG1 monoclonal antibody that targets S. aureus alpha-toxin (virulence factor that is secreted by both MRSA and MSSA). It is designed to protect against alpha-toxin mediated destruction of host cells, preserving a functional host ...
Brand Name : AR-301
Molecule Type : Large molecule
Upfront Cash : Not Applicable
January 25, 2023
Lead Product(s) : Tosatoxumab
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
New Approaches to Treating Infections in Cystic Fibrosis Patients - AR 501 Phase 2 Trial Update
Details : AR-501 is a novel inhaled formulation of gallium citrate with broad-spectrum anti-infective activity involving iron acquisition and metabolism, is being developed to treat chronic lung infections in cystic fibrosis (CF) patients.
Brand Name : AR-501
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 17, 2023
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Study Phase : Phase I/ Phase II
Sponsor : Cystic Fibrosis Foundation
Deal Size : $12.5 million
Deal Type : Funding
CF Foundation Invests Up to $4.85 Million in Aridis Pharmaceuticals for Testing of Anti-Infective
Details : AR-501 is a novel, small molecule and an inhalable form of gallium citrate, which acts as an iron analog to starve bacteria of iron. Gallium is believed to inhibit multiple iron-dependent synthetic and metabolic pathways required for pathogenicity.
Brand Name : AR-501
Molecule Type : Small molecule
Upfront Cash : Undisclosed
December 12, 2022
Lead Product(s) : Gallium Citrate
Therapeutic Area : Genetic Disease
Highest Development Status : Phase I/ Phase II
Sponsor : Cystic Fibrosis Foundation
Deal Size : $12.5 million
Deal Type : Funding
Lead Product(s) : MBP134
Therapeutic Area : Infections and Infectious Diseases
Study Phase : IND Enabling
Recipient : Mapp Biopharmaceutical
Deal Size : Undisclosed
Deal Type : Agreement
Details : The pan-Ebola program, MBP134, is a two mAb cocktail that has demonstrated effectiveness against Sudan virus (SUDV), Zaire Ebola virus (EBOV), Bundibugyo virus (BDBV), Taï Forest virus (TAFV), Reston virus (RESTV), and Bombali ebolavirus (BOMV).
Brand Name : MBP134
Molecule Type : Large molecule
Upfront Cash : Undisclosed
December 05, 2022
Lead Product(s) : MBP134
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : IND Enabling
Recipient : Mapp Biopharmaceutical
Deal Size : Undisclosed
Deal Type : Agreement
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