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Pharmaceutical","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"Oral Inhalation","sponsorNew":"STA Pharmaceutical \/ Qualigen Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"STA Pharmaceutical \/ Qualigen Therapeutics"},{"orgOrder":0,"company":"University of Louisville","sponsor":"Qualigen Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Agreement","leadProduct":"AS1411","moa":"Nucleolin","graph1":"Oncology","graph2":"Preclinical","graph3":"University of Louisville","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"University of Louisville \/ Qualigen Therapeutics","highestDevelopmentStatusID":"4","companyTruncated":"University of Louisville \/ Qualigen 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Find Clinical Drug Pipeline Developments & Deals for AS1411

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                          Top Deals by Deal Size (USD bn)

                          01

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : FDA for Qualigen's QN-165 with an initial target indication for the treatment of COVID-19 in hospitalized patients. QN-165, a DNA aptamer, is a broad-based antiviral drug candidate that has exhibited antiviral activity in multiple in vitro assays against...

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          July 14, 2021

                          Lead Product(s) : AS1411

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          University College London

                          Country arrow
                          MAGHREB PHARMA
                          Not Confirmed

                          University College London

                          Country arrow
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : ALAN is a combination of Qualigen’s AS1411 DNA aptamer plus a DNA-coated gold nanoparticle to dramatically increase its potency. This cancer drug candidate has the potential to target and destroy tumor cells in a various types of cancer with minimal si...

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          January 03, 2021

                          Lead Product(s) : AS1411

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Qualigen Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          03

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : The FDA's response solidifies Qualigen's intention to reprioritize its clinical development program and to first advance AS1411 into clinical trials in the first half of calendar 2021, to be followed by seeking to advance ALAN into clinical trials agains...

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          October 28, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : The new agreement provides a license under UofL's pending U.S. patent for the use of AS1411 for inhibiting or treating COVID-19. Qualigen has separately been developing ALAN as a drug candidate against cancer, under a previous technology license agreeme...

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          October 06, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : University of Louisville

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          05

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : The application covers methods for using the antiviral drug candidate AS1411 to prevent SARS-CoV-2 (the virus that causes COVID-19) from entering the body through mucous membranes in the nose, mouth and eyes.

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          September 17, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : Preclinical studies at the University of Louisville's (UofL) prestigious Center for Infectious Disease have demonstrated the ability of AS1411 to protect cells from the damaging effects of the novel coronavirus by binding to the nucleolin protein.

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          August 31, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Qualigen Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          07

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : Qualigen Therapeutics has signed a contract with STA Pharmaceutical, a subsidiary of WuXi AppTec, for GMP production of AS1411, Qualigen's lead drug candidate for the treatment of COVID-19 and other viral diseases, for potential clinical trials.

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          May 11, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Qualigen Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          08

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : Qualigen offers a number of revenue-generating therapeutic and diagnostic products that may help Ritter Pharmaceuticals to advance its pipeline and grow its business.

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          April 28, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Qualigen Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          09

                          MAGHREB PHARMA
                          Not Confirmed
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : Qualigen has completed the recertification of its supply of AS1411, and has begun final formulation and filling for use in the Company's proposed Phase 2a efficacy trials of AS1411 for the treatment of patients with COVID-19.

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          February 12, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          University of Louisville

                          Country arrow
                          MAGHREB PHARMA
                          Not Confirmed

                          University of Louisville

                          Country arrow
                          MAGHREB PHARMA
                          Not Confirmed

                          Details : Qualigen Therapeutics has entered into an amended Sponsored Research Agreement with the University of Louisville (UofL) to advance development of Qualigen's anticancer drug candidate AS1411-GNP, also known as ALAN (Aptamer-Linked Anti-Nucleolin).

                          Product Name : AS1411

                          Product Type : Oligonucleotide

                          Upfront Cash : Undisclosed

                          January 10, 2020

                          Lead Product(s) : AS1411

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Qualigen Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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