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Applicable"},{"orgOrder":0,"company":"Trigr","sponsor":"Elpiscience","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Collaboration","leadProduct":"TR009","moa":"Dll4-Notch1","graph1":"Oncology","graph2":"Phase I","graph3":"Trigr","amount2":0.12,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.12,"dosageForm":"","sponsorNew":"Trigr \/ Elpiscience Biopharmaceuticals","highestDevelopmentStatusID":"6","companyTruncated":"Trigr \/ Elpiscience Biopharmaceuticals"},{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Asciminib","moa":"Bcr\/Abl","graph1":"Oncology","graph2":"Approved","graph3":"Novartis Pharmaceuticals 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Applicable"}]

Find Clinical Drug Pipeline Developments & Deals for Asciminib

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                          Top Deals by Deal Size (USD bn)

                          01

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : Scemblix (asciminib) works by specifically targeting Bcr/Abl fusion protein. It is being evaluated for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 31, 2024

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : Scemblix (asciminib) works by specifically targeting the ABL myristoyl pocket & acts as Bcr/Abl fusion protein inhibitor. It is being evaluated for the treatment of chronic myeloid leukemia.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          January 08, 2024

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : Approval based on trial, in which Scemblix® (asciminib) nearly doubled major molecular response rate vs. Bosulif®* (bosutinib) (25.5% vs. 13.2%) with more than three times lower discontinuation rate due to adverse reactions at 24 weeks and confirmed at...

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 29, 2022

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : Positive opinion based on data showed near doubling in major molecular response rate for patients treated with Scemblix® (asciminib) vs. Bosulif (bosutinib) and more than 3 times lower discontinuation rate due to adverse reactions at 24 weeks.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 24, 2022

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : Scemblix® (asciminib) continues to show superior efficacy with more-than-two-fold improvement in major molecular response rate vs. Bosulif®* (bosutinib) at 96 weeks (37.6% vs. 15.8%), building on 24-week results.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 07, 2022

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : ES104 (asciminib) demonstrated, 42% overall response rate (ORR) based on 10 patients with Partial Responses (PRs), including 9 PRs confirmed by RECIST 1.1 and 1 PR pending confirmation.

                          Brand Name : ES104

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 05, 2022

                          Lead Product(s) : Asciminib,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : CTX-009 (asciminib), a bispecific antibody demonstrated a 42% overall response rate (ORR) based on 10 patients with Partial Responses (PRs), including 9 PRs confirmed by RECIST 1.1 and 1 PR pending confirmation.

                          Brand Name : CTX-009

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 04, 2022

                          Lead Product(s) : Asciminib,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : CTX-009 (asciminib) is a bispecific antibody that simultaneously targets Delta-like ligand 4 (DLL4) and vascular endothelial growth factor A (VEGF-A), also has demonstrated clinical benefit in heavily pre-treated patients who have progressed after prior ...

                          Brand Name : CTX-009

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 03, 2022

                          Lead Product(s) : Asciminib,Paclitaxel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : New longer-term efficacy and safety data from pivotal Phase III ASCEMBL study for recently US-approved Scemblix® (asciminib) in patients with PH+ CML-CP.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          November 04, 2021

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          The Pharmacy Technology
                          Not Confirmed
                          The Pharmacy Technology
                          Not Confirmed

                          Details : SCEMBLIX® (asciminib) tablets is a prescription medicine used to treat adults with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML) in chronic phase (CP), previously treated with 2 or more tyrosine kinase inhibitor (TKI) medicines.

                          Brand Name : Scemblix

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 29, 2021

                          Lead Product(s) : Asciminib

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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