Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Etakafusp Alfa,Tarlatamab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Amgen Inc
Deal Size : Undisclosed
Deal Type : Collaboration
Asher Bio, BeiGene Collaborate on AB248, T-Cell Engager for Lung Cancer
Details : As part of this collaboration agreement, Amgen will sponsor a global Phase 1b study to evaluate the early efficacy of AB248 (etakafusp alfa) in combination with Imdelltra in patients with ES-SCLC.
Product Name : AB248
Product Type : Protein
Upfront Cash : Undisclosed
January 08, 2025
Lead Product(s) : Etakafusp Alfa,Tarlatamab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Amgen Inc
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Etakafusp Alfa,Rilvegostomig
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : AstraZeneca
Deal Size : Undisclosed
Deal Type : Agreement
Asher Bio, BeiGene Collaborate on AB248 Phase 1b/2 NSCLC Clinical Trial
Details : As part of this agreement, AstraZeneca will operationalize a global study of AB248 (etakafusp alfa) as a first-line treatment in combination with rilvegostomig in patients with advanced NSCLC.
Product Name : AB248
Product Type : Protein
Upfront Cash : Undisclosed
January 07, 2025
Lead Product(s) : Etakafusp Alfa,Rilvegostomig
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : AstraZeneca
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : RA Capital Management
Deal Size : $55.0 million
Deal Type : Series C Financing
Asher Bio Closes $55 Million Series C Financing for Trials
Details : AB248, a novel IL-2 mutein fused to anti-CD8β antibody, is in Phase 1 trials as a CD8+ T cell selective IL-2 for cancer treatment.
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Undisclosed
April 16, 2024
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : RA Capital Management
Deal Size : $55.0 million
Deal Type : Series C Financing
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AB248 is a novel CD8+ T cell selective IL-2, it selectively and potently activate CD8+ T-cells, while avoiding NK cells, which can act as pharmacological sink and contribute to toxicity, and regulatory T (Treg) cells, which are immunosuppressive.
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Not Applicable
January 17, 2023
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AB821
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AB821, a CD8-IL21 cytokine has the potential to treat tumor types that may not be responsive to IL-2 and/or PD-1 therapy. PD-1-resistant tumors are associated with reduced memory T cell numbers and increased exhausted T cell numbers.
Product Name : AB821
Product Type : Cell and Gene therapy
Upfront Cash : Not Applicable
November 03, 2022
Lead Product(s) : AB821
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AB359
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AB359, a CD8-targeted interleukin-2 (IL-2) immunotherapy for the treatment of chronic viral infections is potentially more tolerable and more active IL‑2-based therapy for the treatment of chronic HBV.
Product Name : AB359
Product Type : Large molecule
Upfront Cash : Not Applicable
October 21, 2022
Lead Product(s) : AB359
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AB248
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AB248, Asher Bio’s lead cis-targeted immunotherapy, is a novel CD8-targeted IL-2 mutein designed to selectively activate interleukein-2 (IL-2) signaling on CD8+ T cells over natural killer cells and regulatory T (Treg) cells.
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Not Applicable
October 05, 2022
Lead Product(s) : AB248
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Trial evaluating AB248, a CD8+ T cell cis-targeted IL-2 immunotherapy, in combination with KEYTRUDA, aims to address unmet need for patients who are non-responsive to previous anti-PD-1 therapy or enhance current standard of care in an early line of ther...
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Undisclosed
June 01, 2022
Lead Product(s) : AB248,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Merck & Co
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : AB248
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AB248 demonstrated selectivity, with an approximately 1000-fold preference for the activation of CD8+ T cells over NK cells and Tregs, and induced dose-dependent, selective expansion of CD8+ T cells in non-human primates.
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Not Applicable
April 08, 2022
Lead Product(s) : AB248
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AB248
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : New preclinical data highlight the differentiated efficacy and safety profile of AB248, a fusion protein that selectively activates the IL-2 pathway in CD8+ T cells, which are key drivers of anti-tumor efficacy.
Product Name : AB248
Product Type : Large molecule
Upfront Cash : Not Applicable
March 10, 2022
Lead Product(s) : AB248
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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