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Pharmaceuticals","sponsor":"Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"SWITZERLAND","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Ribociclib","moa":"CDK4\/CDK6","graph1":"Oncology","graph2":"Approved","graph3":"Astex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Astex Pharmaceuticals \/ Astex Pharmaceuticals","highestDevelopmentStatusID":"12","companyTruncated":"Astex Pharmaceuticals \/ Astex Pharmaceuticals"},{"orgOrder":0,"company":"Astex Pharmaceuticals","sponsor":"Otsuka Pharmaceutical","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Guadecitabine","moa":"","graph1":"Oncology","graph2":"Phase III","graph3":"Astex 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Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Astex Pharmaceuticals \/ AstraZeneca","highestDevelopmentStatusID":"15","companyTruncated":"Astex Pharmaceuticals \/ AstraZeneca"}]

Find Clinical Drug Pipeline Developments & Deals by Astex Pharmaceuticals

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                          Top Deals by Deal Size (USD bn)

                          01

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Inqovi is a combination of decitabine and cedazuridine, evaluated in combination with venetoclax for treating higher-risk myelodysplastic syndromes and chronic myelomonocytic leukemia.

                          Product Name : Inqovi

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 22, 2024

                          Lead Product(s) : Decitabine,Cedazuridine,Venetoclax

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Genentech

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Truqap, a first-in-class AKT inhibitor, discovered by AstraZeneca subsequent to its collaboration with Astex, recently approved by FDA in combination with Faslodex, for treatment for adult patients with HR-positive, HER2-negative, locally advanced or met...

                          Product Name : Truqap

                          Product Type : Other Small Molecule

                          Upfront Cash : $5.0 million

                          November 22, 2023

                          Lead Product(s) : Capivasertib,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : AstraZeneca

                          Deal Size : $275.0 million

                          Deal Type : Collaboration

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                          03

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Truqap (capivasertib), a first in class, oral targeted inhibitor of the cancer-driving protein AKT, was discovered by AstraZeneca subsequent to its discovery collaboration with Astex.

                          Product Name : Truqap

                          Product Type : Other Small Molecule

                          Upfront Cash : $5.0 million

                          November 20, 2023

                          Lead Product(s) : Capivasertib,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Sponsor : AstraZeneca

                          Deal Size : $275.0 million

                          Deal Type : Collaboration

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                          04

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Inaqovi (decitabine and cedazuridine) is an orally administered, fixed-dose combination and inhibitor of cytidine deaminase, which is indicated for newly diagnosed acute myeloid leukaemia.

                          Product Name : Inaqovi

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          September 19, 2023

                          Lead Product(s) : Cedazuridine,Decitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved FDF

                          Recipient : Otsuka Holdings

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Under the collaboration, Astex will apply its fragment-based drug discovery platform to develop small molecule candidates targeting multiple forms of the p53 tumour suppressor protein for the treatment of cancer.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : $35.0 million

                          August 08, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery

                          Sponsor : Merck & Co

                          Deal Size : $535.0 million

                          Deal Type : Expanded Collaboration

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                          06

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Under the terms of the agreement, scientists at the MDI and Astex will collaborate to carry out drug discovery research against a chosen lysosomal target with the aim to identify and optimise compounds that modulate its activity to treat neurodegenerativ...

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          February 13, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery

                          Recipient : Cardiff University

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : In new exploratory analysis of data from MONALEESA-2 study, Kisqali (ribociclib) plus letrozole maintained an OS benefit for postmenopausal patients with metastatic breast cancer treated in first-line, including for those patients who required dose modif...

                          Product Name : Kisqali

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 03, 2022

                          Lead Product(s) : Ribociclib,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Novartis Pharmaceuticals Corporation

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : Latest in HR+/HER2- metastatic breast cancer, including data on CDK recycling with Kisqali® plus endocrine therapy, further MONALEESA-2 quality of life and overall survival analyses, and a new biomarker analysis of Piqray® plus fulvestrant.

                          Product Name : Kisqali

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 12, 2022

                          Lead Product(s) : Ribociclib,Letrozole

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Novartis Pharmaceuticals Corporation

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : ASCERTAIN - AML clinical study of decitabine and cedazuridine, as a fixed-dose combination (ASTX727), in adult patients with AML not candidates for chemotherapy demonstrated decitabine exposure equivalence of total 5-day dosing between oral ASTX727 and i...

                          Product Name : ASTX727

                          Product Type : Cytotoxic Drug

                          Upfront Cash : Inapplicable

                          May 12, 2022

                          Lead Product(s) : Decitabine,Cedazuridine

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Immuno-Oncology 360
                          Not Confirmed
                          Immuno-Oncology 360
                          Not Confirmed

                          Details : With further follow-up of MONALEESA-3, Kisqali (ribociclib) plus fulvestrant achieved a median overall survival (OS) of more than five-and-a-half years (67.6 months) in the first-line (1L) setting for postmenopausal women living with HR+/HER2- aBC.

                          Product Name : Kisqali

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 04, 2022

                          Lead Product(s) : Ribociclib,Fulvestrant

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Novartis Pharmaceuticals Corporation

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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