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Biosciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Collaboration","leadProduct":"Casdatifan","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ AstraZeneca","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ AstraZeneca"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Aim ImmunoTech","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Rintatolimod","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ AstraZeneca","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ AstraZeneca"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Datopotamab Deruxtecan","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ Not Applicable"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Daiichi Sankyo","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Trastuzumab Deruxtecan","moa":"","graph1":"Technology","graph2":"Phase 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Sankyo","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Trastuzumab Deruxtecan","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ AstraZeneca","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ AstraZeneca"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Albuterol Sulfate","moa":"","graph1":"Technology","graph2":"Phase 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Pharmaceuticals"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Eccogene","pharmaFlowCategory":"D","therapeuticArea":"Nutrition and Weight Loss","country":"","productType":"Small molecule","year":"2024","type":"Licensing Agreement","leadProduct":"AZD5004","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":2.0099999999999998,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ AstraZeneca","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ AstraZeneca"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Palivizumab","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ Not Applicable"},{"orgOrder":0,"company":"AstraZeneca","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Tremelimumab","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"AstraZeneca","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"AstraZeneca \/ Not Applicable","highestDevelopmentStatusID":"14","companyTruncated":"AstraZeneca \/ Not Applicable"},{"orgOrder":0,"company":"Alexion Pharmaceuticals","sponsor":"Merck & Co","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Selumetinib","moa":"","graph1":"Technology","graph2":"Phase I\/II","graph3":"Alexion Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Technology","amount2New":0.94999999999999996,"dosageForm":"","sponsorNew":"Alexion Pharmaceuticals \/ Merck & Co","highestDevelopmentStatusID":"14","companyTruncated":"Alexion Pharmaceuticals \/ Merck & Co"}]

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                            01

                            AstraZeneca

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                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ENHERTU® Granted PR for HER2 Low or Ultralow Metastatic Breast Cancer Patients

                            Details : Enhertu (trastuzumab deruxtecan) is a HER2-directed ADC which is being evaluated for the treatment of previously treated patients with HR positive, HER2 low metastatic breast cancer.

                            Brand Name : Enhertu

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 30, 2024

                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            AstraZeneca

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                            Lead Product(s) : Datopotamab Deruxtecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Datopotamab Deruxtecan Overall Survival Results Reported in Metastatic Breast Cancer

                            Details : Dato-DXd (datopotamab deruxtecan) in combination with Imfinzi (durvalumab) is being evaluated for advanced or metastatic HR-positive, HER2-negative breast cancer.

                            Brand Name : Dato-DXd

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 23, 2024

                            Lead Product(s) : Datopotamab Deruxtecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            AstraZeneca

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                            Lead Product(s) : Dapagliflozin

                            Therapeutic Area : Endocrinology

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Farxiga approved in the US for the treatment of paediatric type-2 diabetes

                            Details : Farxiga (dapagliflozin), is first-in-class, oral, USFDA approved, once-daily SGLT2 inhibitor, for paediatric patients with type-2 diabetes aged 10 years and older.

                            Brand Name : Farxiga

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 12, 2024

                            Lead Product(s) : Dapagliflozin

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            AstraZeneca

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                            Lead Product(s) : Ac225-PSMA

                            Therapeutic Area : Oncology

                            Study Phase : Phase II/ Phase III

                            Recipient : Fusion Pharma

                            Deal Size : $2,400.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Acquisition of Fusion Pharmaceuticals Completed

                            Details : Through the acquisition, AstraZeneca will leverage the Fusion pipeline, which includes FPI-2265, a potential new treatment for patients with metastatic castration-resistant prostate cancer.

                            Brand Name : FPI-2265

                            Molecule Type : Small molecule

                            Upfront Cash : $2,000.0 million

                            June 04, 2024

                            Lead Product(s) : Ac225-PSMA

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II/ Phase III

                            Recipient : Fusion Pharma

                            Deal Size : $2,400.0 million

                            Deal Type : Acquisition

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                            05

                            AstraZeneca

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                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ENHERTU® Shows 13.2-Month PFS in HER2-Low Metastatic Breast Cancer After Endocrine Therapy

                            Details : Enhertu (trastuzumab deruxtecan) is a HER2-directed ADC which is being evaluated for the treatment of previously treated patients with HR positive, HER2 low metastatic breast cancer.

                            Brand Name : Enhertu

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 02, 2024

                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            AstraZeneca

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                            Lead Product(s) : Rilvegostomig

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Compugen

                            Deal Size : $210.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Compugen Receives Milestone Payment for Dosing First Patient in Phase 3 of Rilvegostomig

                            Details : AZD2936 (rilvegostomig) is a PD-1/TIGIT bispecific antibody where the TIGIT component is derived from Compugen's clinical stage anti-TIGIT antibody, COM902.

                            Brand Name : AZD2936

                            Molecule Type : Large molecule

                            Upfront Cash : $10.0 million

                            May 30, 2024

                            Lead Product(s) : Rilvegostomig

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Compugen

                            Deal Size : $210.0 million

                            Deal Type : Licensing Agreement

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                            07

                            AstraZeneca

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                            Lead Product(s) : Monoclonal Antibody-based Therapy

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Nona Biosciences

                            Deal Size : $604.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Nona Biosciences Signs Global License with AstraZeneca for Monoclonal Antibody Development

                            Details : Under the agreement, AstraZeneca will have the exclusive global license for preclinical monoclonal antibodies that will be used to create targeted therapies in oncology.

                            Brand Name : Undisclosed

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            May 22, 2024

                            Lead Product(s) : Monoclonal Antibody-based Therapy

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Nona Biosciences

                            Deal Size : $604.0 million

                            Deal Type : Licensing Agreement

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                            08

                            AstraZeneca

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                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ENHERTU® Shows Significant Progression-Free Survival in HER2 Low Metastatic Breast Cancer

                            Details : Enhertu (trastuzumab deruxtecan) is a HER2-directed antibody-drug conjugate in phase 3 trials for HR-positive, HER2-low metastatic breast cancer.

                            Brand Name : Enhertu

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 29, 2024

                            Lead Product(s) : Trastuzumab Deruxtecan

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Recipient : Daiichi Sankyo

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            AstraZeneca

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                            Lead Product(s) : Durvalumab,Cisplatin,Gemcitabine

                            Therapeutic Area : Oncology

                            Study Phase : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            IMFINZI® plus Chemotherapy Doubles Survival Rate for Advanced Biliary Tract Cancer

                            Details : Imfinzi (durvalumab), a human monoclonal antibody targeting PD-L1, is under evaluation for treating locally advanced or metastatic biliary tract cancer.

                            Brand Name : Imfinzi

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 16, 2024

                            Lead Product(s) : Durvalumab,Cisplatin,Gemcitabine

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase III

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Nirsevimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Approved

                            Sponsor : Sanofi

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Beyfortus Approved in Japan for the Prevention of RSV Disease in Infants

                            Details : Beyfortus (nirsevimab) is a long-acting antibody approved in China for preventing RSV lower respiratory tract infections in neonates and infants during their first RSV season.

                            Brand Name : Beyfortus

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 27, 2024

                            Lead Product(s) : Nirsevimab

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Approved

                            Sponsor : Sanofi

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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