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    [{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nephrology","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Atrasentan","moa":"Endothelin A receptor","graph1":"Nephrology","graph2":"Approved FDF","graph3":"Novartis Pharmaceuticals Corporation","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet, Film Coated","sponsorNew":"Novartis Pharmaceuticals Corporation \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Novartis Pharmaceuticals Corporation \/ Inapplicable"},{"orgOrder":0,"company":"AbbVie Inc","sponsor":"Chinook Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Licensing Agreement","leadProduct":"Atrasentan","moa":"Endothelin A 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Leerink"},{"orgOrder":0,"company":"Chinook Therapeutics","sponsor":"SVB Securities","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Public Offering","leadProduct":"Atrasentan","moa":"Endothelin A receptor","graph1":"Nephrology","graph2":"Phase III","graph3":"Chinook Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Chinook Therapeutics \/ SVB Securities","highestDevelopmentStatusID":"10","companyTruncated":"Chinook Therapeutics \/ SVB Securities"},{"orgOrder":0,"company":"SanReno Therapeutics","sponsor":"Novartis Pharmaceuticals Corporation","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"CHINA","productType":"Other Small Molecule","year":"2024","type":"Acquisition","leadProduct":"Atrasentan","moa":"Endothelin A receptor","graph1":"Nephrology","graph2":"Phase III","graph3":"SanReno Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet, Film Coated","sponsorNew":"SanReno Therapeutics \/ Novartis Pharmaceuticals Corporation","highestDevelopmentStatusID":"10","companyTruncated":"SanReno Therapeutics \/ Novartis Pharmaceuticals Corporation"},{"orgOrder":0,"company":"Novartis Pharmaceuticals Corporation","sponsor":"CareMed","pharmaFlowCategory":"D","therapeuticArea":"Nephrology","country":"SWITZERLAND","productType":"Other Small Molecule","year":"2025","type":"Partnership","leadProduct":"Atrasentan","moa":"Endothelin A receptor","graph1":"Nephrology","graph2":"Approved FDF","graph3":"Novartis Pharmaceuticals Corporation","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Nephrology","amount2New":0,"dosageForm":"Oral Tablet, Film Coated","sponsorNew":"Novartis Pharmaceuticals Corporation \/ CareMed","highestDevelopmentStatusID":"15","companyTruncated":"Novartis Pharmaceuticals Corporation \/ CareMed"}]

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                            01

                            AbbVie Inc

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Chinook Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Chinook Therapeutics Obtains Worldwide Rights from AbbVie to Atrasentan with Plans to Develop for the Treatmen...

                            Details : Chinook Therapeutics in-license of atrasentan provides a unique opportunity for Chinook to add a potential new drug to its precision medicine portfolio for the treatment of rare CKD conditions.

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            October 01, 2020

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Chinook Therapeutics

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            02

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : CareMed

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            CareMed Chosen As Specialty Pharmacy Partner For VANRAFIA

                            Details : The partnership aims to distribute Novartis' Vanrafia (atrasentan HCl) through CareMed. It is indicated for the treatment of proteinuria in adults with primary immunoglobulin A nephropathy.

                            Product Name : Vanrafia

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            April 07, 2025

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : CareMed

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            03

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Novartis Gets FDA Approval for Vanrafia® to Reduce Proteinuria in IgAN

                            Details : Vanrafia (atrasentan HCl) is an investigational oral endothelin A receptor antagonist (ERA), which is approved for IgAN and early-stage development for other rare kidney diseases.

                            Product Name : Vanrafia

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            April 02, 2025

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Approved FDF

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Novartis Pharmaceuticals Corporation

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                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Novartis Shows Proteinuria Reduction Data from Atrasentan Phase III Trial in IgAN

                            Details : CHK-01 (atrasentan HCl) is an investigational oral endothelin A receptor antagonist (ERA), currently in Phase III development for IgAN and early-stage development for other rare kidney diseases

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 25, 2024

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            SanReno Therapeutics

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            SanReno Acquired By Novartis for Kidney Disease Therapeutics

                            Details : Novartis will acquire SanReno's pipeline, gaining exclusive rights for Greater China and Singapore for late-stage IgAN assets, ABT-627 (oral ERA antagonist) and zigakibart (monoclonal antibody).

                            Product Name : ABT-627

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            May 01, 2024

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : Undisclosed

                            Deal Type : Acquisition

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                            06

                            Chinook Therapeutics

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Novartis Bolsters Innovative Medicines Strategy and Renal Pipeline with Agreement to Acquire Chinook Therapeut...

                            Details : Through the acquisition, Novartis expands its portfolio with chinook's renal pipeline having 2 assets, CHK-01 (atrasentan hydrochloride), an oral endothelin A receptor antagonist and BION-1301 (zigakibart), an anti-APRIL monoclonal antibody, for Immunogl...

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : $3,500.0 million

                            December 06, 2023

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

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                            07

                            Chinook Therapeutics

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                            Chinook Therapeutics

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Novartis Completes Acquisition of Chinook Therapeutics

                            Details : Through the acquisition, Novartis expands its portfolio with chinook's renal pipeline having 2 assets, CHK-01 (atrasentan hydrochloride), an oral endothelin A receptor antagonist and BION-1301 (zigakibart), an anti-APRIL monoclonal antibody, for Immunogl...

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : $3,500.0 million

                            November 08, 2023

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Novartis Pharmaceuticals Corporation

                            Deal Size : $3,500.0 million

                            Deal Type : Acquisition

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                            08

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Novartis investigational atrasentan Phase III study demonstrates clinically meaningful and highly statisticall...

                            Details : CHK-01 (atrasentan hydrochloride) is an investigational oral endothelin A receptor antagonist (ERA), currently in Phase III development for IgAN and early-stage development for other rare kidney diseases

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 30, 2023

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Novartis Pharmaceuticals Corporation

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Novartis Investigational Atrasentan Phase III Study Demonstrates Clinically Meaningful and Highly Statisticall...

                            Details : CHK-01 (atrasentan hydrochloride), an oral endothelin A receptor antagonist is being evaluated phase 3 clinical trials for proteinuria reduction in patients with IgA nephropathy.

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            October 30, 2023

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Chinook Therapeutics

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                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Study Phase : Phase III

                            Sponsor : SVB Securities

                            Deal Size : $105.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Chinook Therapeutics Announces Pricing of a $105 Million Public Offering

                            Details : Chinook intends to use the net proceeds from this offering to continue its phase 3 ALIGN and phase 2 AFFINITY trials of atrasentan, fund a phase 3 clinical trial of BION-1301, continue development of CHK-336 and prepare for the potential commercial launc...

                            Product Name : CHK-01

                            Product Type : Other Small Molecule

                            Upfront Cash : Undisclosed

                            May 25, 2022

                            Lead Product(s) : Atrasentan

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase III

                            Sponsor : SVB Securities

                            Deal Size : $105.0 million

                            Deal Type : Public Offering

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