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Find Clinical Drug Pipeline Developments & Deals for Atuzaginstat
COR 388 (atuzaginstat) is an orally administered bacterial protease inhibitor, being developed for treatment of Alzheimer's Disease, targets the toxic proteases, or gingipains, produced by P. gingivalis, which have been discovered in greater than 90% of AD patients.
By engaging a novel upstream target, COR388 (atuzaginstat) demonstrated numerical trends to benefit in tau biomarkers, which is consistent with the observed slowing of Alzheimer’s disease progression.
Gain trial will assess the efficacy, safety, and tolerability of 2 dose levels of COR388 (atuzaginstat) oral capsules in subjects with probable AD dementia according to the National Institute on Aging-Alzheimer's Association (NIA-AA) criteria.
First-in-class lysine gingipain inhibitor, atuzaginstat, has the potential to reduce the malignant progression of oral potentially malignant disorders, In vitro study results demonstrate that PD-L1 is induced by P. gingivalis and can be blocked by atuzaginstat.
COR388 (atuzaginstat), a novel gingipain inhibitor decreases fragmentation of APOE in the central nervous system of Alzheimer’s disease patients in a Phase 2/3 GAIN Trial for P. gingivalis infection.
The study data showed that treatment with atuzaginstat slowed decline compared to placebo on the majority of clinical endpoints in prespecified populations that were selected based on P. gingivalis infection markers.
Atuzaginstat (COR388), an investigational orally administered small-molecule that targets gingipain proteases from the bacterium Porphyromonas gingivalis (P. gingivalis) to treat moderate patients with Alzheimer’s disease.
Cortexyme shares updated and new baseline biomarker data from the full set of patients in the study that supports that this is an appropriate population for testing atuzaginstat for Alzheimer’s disease.
Two poster presentations covering an update from its pivotal Phase 2/3 GAIN Trial of atuzaginstat, in addition to new data demonstrating the upstream role that P. gingivalis plays in key pathology of Alzheimer’s disease.
Multiple studies were used to determine an effective exposure and dose regimen. A previously peer-reviewed publication established efficacy of atuzaginstat in reducing oral infection and periodontal disease in a naturally occurring aged dog model.
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