Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : AUM001,Pembrolizumab,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AUM001 is a mRNA translation inhibitor that targets MNK 1/2 and the chokepoint of multiple pro-oncogenic signalling pathways, being investigated for the treatment of metastatic colorectal cancer.
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 30, 2023
Lead Product(s) : AUM001,Pembrolizumab,Irinotecan Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AUM001 is highly selective translation inhibitor. In vitro, it was observed to selectively inhibit MAPK – interacting protein kinase (MNK) types 1/2 and is expected to thereby block phosphorylation of eIF4E, and in turn, interfere with CAP mediated RNA...
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 15, 2022
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Mountain Crest Acquisition Corp. V
Deal Size : Undisclosed
Deal Type : Merger
Details : AUM001 is a selective and synergistic MNK inhibitor as shown in current studies and expected to begin Phase 2 enrollment in the fourth quarter 2022. AUM601 is a promising therapy for TRK fusions and mutations within the kinase domain and is on track to e...
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 20, 2022
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Mountain Crest Acquisition Corp. V
Deal Size : Undisclosed
Deal Type : Merger
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : As a result, AUM plans to evaluate AUM001, in combination with MSD’s anti-PD-1 therapy KEYTRUDA (pembrolizumab), in a global Phase 2 clinical trial in patients with microsatellite stable colorectal cancer (MSS CRC).
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 07, 2022
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : MSD Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : This collaboration with MSD marks a major milestone and enables the joint clinical development of AUM001 in combination with KEYTRUDA. As a monotherapy, AUM001 demonstrated encouraging safety, tolerability and target engagement in two Phase 1 studies.
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
May 05, 2022
Lead Product(s) : AUM001,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : MSD Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : AUM001
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : SPRIM Global investments
Deal Size : $27.0 million
Deal Type : Series A Financing
Details : AUM plans to use the proceeds to advance the clinical development of its portfolio with immediate initiation of two Phase II programs for MNK and TRK inhibitors including AUM001.
Brand Name : AUM001
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 12, 2021
Lead Product(s) : AUM001
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : SPRIM Global investments
Deal Size : $27.0 million
Deal Type : Series A Financing
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