Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : BNT211,CARVac
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $250.0 million
Deal Type : Collaboration
BioNTech and Autolus Collaborate To Advance CAR-T Cell Therapy Pipeline
Details : The collaboration will support Autolus in developing BNT211 (CLDN6 CAR-T) for treating relapsed or refractory advanced solid tumors, including ovarian cancer and sarcoma.
Brand Name : BNT211
Molecule Type : Cell and Gene therapy
Upfront Cash : $50.0 million
February 08, 2024
Lead Product(s) : BNT211,CARVac
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : BioNTech
Deal Size : $250.0 million
Deal Type : Collaboration
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Autolus Announces Acceptance of BLA for Obe-Cel in B-cell ALL Treatment
Details : AUTO1 (obecabtagene autoleucel) is a CD19 CAR T cell investigational therapy. It is being evaluated in phase 1/2 clinical trials for relapsed/refractory adult B-cell Acute Lymphoblastic Leukemia.
Brand Name : AUTO1
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
January 22, 2024
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obecabtagene Autoleucel
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering
Autolus Announces Pricing of Public Offering
Details : AUTO1 (obecabtagene autoleucel) is an autologous CD19 CAR T cell therapy with a unique CD19 CAR. The CAR is designed to have a fast-off kinetic which mimics physiological T-cell receptor interactions.
Brand Name : AUTO1
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
December 08, 2022
Lead Product(s) : Obecabtagene Autoleucel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Jefferies
Deal Size : $150.0 million
Deal Type : Public Offering
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Obe-cel (AUTO1), is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies.
Brand Name : AUTO1
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 08, 2022
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : mRNA-based Therapeutic
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Moderna Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Moderna Exercises Option To License Proprietary Targeting Technology From Autolus
Details : This follows an original agreement with Moderna, granting Moderna an exclusive option to license Autolus’ proprietary binders for up to four immuno-oncology targets for incorporation in certain mRNA therapeutics.
Brand Name : Undisclosed
Molecule Type : Large molecule
Upfront Cash : Undisclosed
October 12, 2022
Lead Product(s) : mRNA-based Therapeutic
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Moderna Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Lead Product(s) : CAR-T Cell Therapy
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Bristol Myers Squibb
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the terms of the agreement, Autolus will receive payment for access to the RQR8 safety switch for the initial set of cell therapy programs with the potential for near term option exercise fees and development milestone payments.
Brand Name : Undisclosed
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
October 04, 2022
Lead Product(s) : CAR-T Cell Therapy
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Bristol Myers Squibb
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : AUTO4,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : AUTO4 is a programmed T cell product candidate in clinical development for T cell lymphoma, a setting where there are currently no approved programmed T cell therapies.
Brand Name : AUTO4
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
May 12, 2022
Lead Product(s) : AUTO4,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Obecabatagene autoleucel, a CD19-directed autologous CAR-T therapy, reduce toxicity and be less prone to T cell exhaustion, which could enhance persistence and improve ability of programmed T cells to engage in serial killing of target cancer cells.
Brand Name : AUTO1
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
April 25, 2022
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Obe-cel is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies. Obe-cel is currently being evaluated in a Phase 1 clinical trials for B-NHL.
Brand Name : Obe-cel
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
March 31, 2022
Lead Product(s) : Obecabtagene Autoleucel,Cyclophosphamide,Fludarabine Phosphate
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obecabtagene Autoleucel
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Blackstone Life Sciences
Deal Size : $250.0 million
Deal Type : Acquisition
Details : Obecabtagene Autoleucel (Obe-cel) is a CD19 CAR T cell investigational therapy designed to overcome the limitations in clinical activity and safety compared to current CD19 CAR T cell therapies used in adult ALL and B-NHL.
Brand Name : Obe-cel
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
November 08, 2021
Lead Product(s) : Obecabtagene Autoleucel
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Blackstone Life Sciences
Deal Size : $250.0 million
Deal Type : Acquisition
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