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    [{"orgOrder":0,"company":"AviadoBio","sponsor":"New Enterprise Associates","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Cell and Gene therapy","year":"2021","type":"Series A Financing","leadProduct":"AVB-PGRN","moa":"","graph1":"Neurology","graph2":"Preclinical","graph3":"AviadoBio","amount2":0.080000000000000002,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0.080000000000000002,"dosageForm":"Intrathalamic","sponsorNew":"AviadoBio \/ New Enterprise Associates","highestDevelopmentStatusID":"4","companyTruncated":"AviadoBio \/ New Enterprise Associates"},{"orgOrder":0,"company":"AviadoBio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not 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    Find Clinical Drug Pipeline Developments & Deals by AviadoBio

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                            01

                            AviadoBio

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Astellas Pharma

                            Deal Size : $2,230.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Astellas & AviadoBio Announce License Agreement of AVB-101 for Frontotemporal Dementia

                            Details : Astellas receives an exclusive option to license AVB-101, an investigational, AAV-based gene therapy in Phase 1/2 development for patients with frontotemporal dementia with progranulin mutations.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : $50 million

                            October 08, 2024

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Astellas Pharma

                            Deal Size : $2,230.0 million

                            Deal Type : Agreement

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                            02

                            AviadoBio

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                            Lead Product(s) : AAV-PGRN

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : The Ohio State University Wexner Medical Center

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ASPIRE-FTD Phase 1/2 Trial Opens at Ohio State University Wexner Medical Center

                            Details : AVB-101 (AAV-PGRN) is an investigational gene therapy delivered as a one-time intrathalamic infusion, enabling distribution to brain areas affected by GRN-mutated FTD while limiting systemic exposure.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            July 01, 2024

                            Lead Product(s) : AAV-PGRN

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : The Ohio State University Wexner Medical Center

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            AviadoBio Announces First Patient Treated in ASPIRE-FTD Trial Evaluating AVB-101

                            Details : AVB-101 is an investigational gene therapy that contains a correct (non-mutated) version of the GRN gene. It is being evaluated for the treatment of frontotemporal dementia with GRN mutations.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 15, 2024

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            AviadoBio Announces FDA IND Clearance and Fast Track Designation for AVB-101 for the Treatment of Frontotempor...

                            Details : AVB-101 is an investigational gene therapy delivered as a one-time infusion directly to the brain, enabling distribution to brain areas affected by FTD while limiting systemic exposure.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            November 06, 2023

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            AviadoBio Announces Initiation of Phase 1/2 Clinical Trial, ASPIRE-FTD, Evaluating AVB-101 in People with Fron...

                            Details : AVB-101 is an investigational gene therapy designed to halt disease progression by delivering a functional copy of the GRN gene to restore appropriate progranulin levels in the brain for the treatment of frontotemporal dementia.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            October 10, 2023

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            AviadoBio Presents Preclinical Data at ASGCT 2022 Demonstrating that AVB-101 Represents a Novel and Promising ...

                            Details : In pre-clinical pharmacology studies, AVB-101 administration via intrathalamic injection, in a progranulin-deficient mouse model, demonstrated neuronal specific PGRN brain expression and reduction in disease pathology.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 17, 2022

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            AviadoBio to Present Pre-clinical Data on its Gene Therapy Candidate for Frontotemporal Dementia at ASGCT 2022

                            Details : AVB-101 is an investigational AAV gene therapy designed to slow or stop disease progression by delivering a functional copy of the GRN gene throughout the central nervous system to restore progranulin levels.

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 04, 2022

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            AviadoBio’s Gene Therapy Candidate Receives Orphan Designation from Food and Drug Administration and Europea...

                            Details : AVB-101, an investigational, adeno-associated virus gene therapy designed for patients with FTD with mutations in progranulin gene, designed to slow or arrest disease progression by delivering a functional copy of GRN gene throughout CNS to restore norma...

                            Brand Name : AVB-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 27, 2022

                            Lead Product(s) : AVB-101

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            AviadoBio

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                            Lead Product(s) : AVB-PGRN

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : New Enterprise Associates

                            Deal Size : $80.0 million

                            Deal Type : Series A Financing

                            DEALS_DEV arrow-down

                            AviadoBio™ Raises $80 million in Series A Financing to Advance Neurodegenerative Gene Therapy Platform

                            Details : The funds will be used to advance AviadoBio’s lead program AVB-PGRN, in frontotemporal dementia (FTD) into the clinic, progress its preclinical assets, including for amyotrophic lateral sclerosis (ALS), whilst continuing to expand its industry-leading ...

                            Brand Name : AVB-PGRN

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            December 02, 2021

                            Lead Product(s) : AVB-PGRN

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : New Enterprise Associates

                            Deal Size : $80.0 million

                            Deal Type : Series A Financing

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