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    [{"orgOrder":0,"company":"vTv Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Azeliragon","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"vTv Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Capsule","sponsorNew":"vTv Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"vTv Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"vTv Therapeutics","sponsor":"Lincoln Park Capital Fund","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"","productType":"Small molecule","year":"2020","type":"Agreement","leadProduct":"Azeliragon","moa":"","graph1":"Neurology","graph2":"Phase III","graph3":"vTv Therapeutics","amount2":0.050000000000000003,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals for Azeliragon

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                            01

                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex Pharmaceuticals Gets FDA Orphan Drug Status for Azeliragon in Pancreatic Cancer

                            Details : TTP488 (azeliragon) is an oral capsule, inhibiting interactions of the receptor for advanced glycation end products with ligands, including HMGB1 and S100 proteins in the tumor microenvironment.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 20, 2024

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase III

                            Sponsor : Michigan Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex and Michigan Medicine Announce Initiation of a Randomized, Double-Blind, Placebo-Controlled, Multicente...

                            Details : TTP488 (azeliragon), is an orally active, small molecule, antagonist of the receptor for advanced glycation endproducts (RAGE). It is being investigated for the treatment of hospitalized patients for COVID-19 infection.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 27, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase III

                            Sponsor : Michigan Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex and Allegheny Health Network Announce Initiation of a Phase 1/2 Study of Azeliragon in Patients Refract...

                            Details : TTP488 (azeliragon), is an orally active, small molecule, antagonist of the receptor for advanced glycation endproducts (RAGE). It is being investigated for the treatment of refractory to first-line treatment of metastatic pancreatic cancer.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 26, 2023

                            Lead Product(s) : Azeliragon,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Lenox Hill Hospital

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex Pharmaceuticals and Lenox Hill Hospital Announce Initiation of a Phase 2 Study of RAGE Inhibitor Azelir...

                            Details : TTP488 (azeliragon), is an orally active, small molecule, antagonist of the receptor for advanced glycation endproducts (RAGE). It is being investigated for the treatment of patients newly diagnosed unmethylated glioblastoma.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 18, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Lenox Hill Hospital

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon,Dexamethasone

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex Pharmaceuticals Announces Initiation of an Investigator-Initiated Phase 2 Clinical Trial Investigating ...

                            Details : Azeliragon is an orally administered capsule, taken once daily, that inhibits interactions of RAGE with certain ligands, including HMGB1 and S100 proteins in the tumor microenvironment.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            August 28, 2023

                            Lead Product(s) : Azeliragon,Dexamethasone

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Georgetown University

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                            Georgetown University

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                            Lead Product(s) : Azeliragon,Doxorubicin Hydrochloride,Cyclophosphamide

                            Therapeutic Area : Neurology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Cantex Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            vTv Therapeutics Partner Cantex Pharmaceuticals Licenses Exclusive Rights to Intellectual Property from George...

                            Details : Under the agreement, Cantex gets exclusive worldwide license for intellectual property related to the potential use of TTP488 (azeliragon), a small molecule RAGE inhibitor, to treat, prevent or alleviate cancer treatment-related cognitive decline.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            June 16, 2023

                            Lead Product(s) : Azeliragon,Doxorubicin Hydrochloride,Cyclophosphamide

                            Therapeutic Area : Neurology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Cantex Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            07

                            Georgetown University

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                            Georgetown University

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Psychiatry/Psychology

                            Study Phase : Preclinical

                            Sponsor : Cantex Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Cantex Pharmaceuticals Obtains Exclusive Worldwide Rights to Intellectual Property from Georgetown University ...

                            Details : Under the agreement, Cantex obtained an exclusive worldwide license for intellectual property related to the potential use of TTP-488 (azeliragon) to treat, prevent or alleviate cancer-treatment related cognitive decline.

                            Brand Name : TTP-488

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            June 01, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Psychiatry/Psychology

                            Highest Development Status : Preclinical

                            Sponsor : Cantex Pharmaceuticals

                            Deal Size : Undisclosed

                            Deal Type : Licensing Agreement

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                            08

                            vTv Therapeutics

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                            vTv Therapeutics

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            vTv Therapeutics Announces Issuance of U.S. Patent for Azeliragon as a Treatment of Glioblastoma to Cantex Pha...

                            Details : TTP488 (azeliragon) is an orally administered small molecule, taken once daily, that inhibits interactions of the receptor for advanced glycation end products (known as RAGE) with certain ligands, including HMGB1 and S100 proteins in the glioblastoma mic...

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 24, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Cantex Pharmaceuticals

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                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex Pharmaceuticals Announces Issuance of A Patent for Azeliragon as A Treatment of Glioblastoma

                            Details : TTP488 (azeliragon) is an orally active, small molecule, antagonist of the receptor for advanced glycation endproducts (RAGE). By preventing interaction of RAGE with these ligands, azeliragon may inhibit glioblastoma and overcome its resistance to effect...

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 16, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Cantex Pharmaceuticals

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                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II/ Phase III

                            Sponsor : Michigan Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Cantex and Michigan Medicine Announce Initiation of a Randomized, Double-Blind, Placebo-Controlled Phase 2/3 C...

                            Details : TTP488 (azeliragon), is an orally active, small molecule, antagonist of the receptor for advanced glycation endproducts (RAGE). It is being investigated for the treatment of patients hospitalized for COVID-19.

                            Brand Name : TTP488

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 20, 2023

                            Lead Product(s) : Azeliragon

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II/ Phase III

                            Sponsor : Michigan Medicine

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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