Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Ibrutinib,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The disappointed outcome of the confirmatory trials leads to voluntarily withdraw, in the U.S., accelerated IMBRUVICA® (ibrutinib) approvals for patients with the blood cancers mantle cell lymphoma who have received at least one prior therapy and with m...
Brand Name : Imbruvica
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 06, 2023
Lead Product(s) : Ibrutinib,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Johnson & Johnson Innovative Medicine
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
CALQUENCE® Granted Priority Review in The U.S. For Untreated Mantle Cell Lymphoma
Details : Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.
Brand Name : Calquence
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 03, 2024
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Acerta Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
CALQUENCE Plus Chemoimmunotherapy Reduces Progression Risk in Lymphoma Trial
Details : Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.
Brand Name : Calquence
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 16, 2024
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Acerta Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Acerta Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
CALQUENCE Combo Shows Significant Improvement in Progression-Free Survival in Lymphoma
Details : Calquence (acalabrutinib) is a next-generation, selective inhibitor of bruton’s tyrosine kinase (BTK). It is being evaluated for the treatment of mantle cell lymphoma in adults.
Brand Name : Calquence
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 02, 2024
Lead Product(s) : Acalabrutinib,Bendamustine Hydrochloride,Rituximab
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Acerta Pharma
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Apotex Corp. Launches Bendamustine Hydrochloride Injection in the United States
Details : Bendamustine hydrochloride is a bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring, which can lead to cell death via several pathways. It is active against both quiescent and dividing cells.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 26, 2023
Lead Product(s) : Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Dr. Reddy\'s Laboratories
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the settlement agreement, Dr. Reddy’s has the right to market its product BENDEKA® (bendamustine hydrochloride), an alkylating drug, indicated for treatment of patients with Chronic lymphocytic leukemia.
Brand Name : Bendeka
Molecule Type : Small molecule
Upfront Cash : Undisclosed
April 05, 2023
Lead Product(s) : Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Dr. Reddy\'s Laboratories
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The results demonstrated TT11 to be well-tolerated with promising efficacy in relapsed or refractory (r/r) CD30-positive classical Hodgkin lymphoma (cHL). The CD30.CAR-T cell therapy was demonstrated to be well tolerated with no unexpected safety signals...
Brand Name : TT11
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
December 12, 2022
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Rad51-IN-2,Rituximab,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : CYT-0851 is in a Phase 1/2 clinical trial as both a monotherapy and in combination with standard of care chemotherapy and has the potential to be a first-in-class MCT inhibitor. By impairing monocarboxylate transporter-mediated lactate transport, CYT-085...
Brand Name : CYT-0851
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 12, 2022
Lead Product(s) : Rad51-IN-2,Rituximab,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TT11 – is an autologous CD30 targeting CAR-T therapy currently being investigated as a potential treatment for relapsed or refractory classical Hodgkin lymphoma.
Brand Name : TT11
Molecule Type : Cell and Gene therapy
Upfront Cash : Not Applicable
June 13, 2022
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Polaris Partners
Deal Size : $126.0 million
Deal Type : Series A Financing
Tessa Therapeutics Completes US$126 Million Financing Led by Polaris Partners
Details : Tessa plans to use the proceeds from the financing to advance the ongoing clinical development of the company’s autologous CD30-CAR-T therapy (TT11) and allogeneic CD30.CAR EBVST therapy (TT11X) programs.
Brand Name : TT11
Molecule Type : Cell and Gene therapy
Upfront Cash : Undisclosed
June 09, 2022
Lead Product(s) : CD30.CAR-T,Fludarabine Phosphate,Bendamustine Hydrochloride
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Polaris Partners
Deal Size : $126.0 million
Deal Type : Series A Financing
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