[{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Biocon","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2021","type":"Financing","leadProduct":"BCA101","moa":"EGFR","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Bicara Therapeutics","amount2":0.040000000000000001,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0.040000000000000001,"dosageForm":"","sponsorNew":"Bicara Therapeutics \/ Biocon","highestDevelopmentStatusID":"7","companyTruncated":"Bicara Therapeutics \/ Biocon"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2022","type":"Not Applicable","leadProduct":"BCA101","moa":"EGFR","graph1":"Oncology","graph2":"Phase I","graph3":"Bicara Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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Capital","highestDevelopmentStatusID":"6","companyTruncated":"Bicara Therapeutics \/ Red Tree Venture Capital"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Braidwell LP","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2023","type":"Series C Financing","leadProduct":"BCA101","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Bicara Therapeutics","amount2":0.17000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.17000000000000001,"dosageForm":"Infusion","sponsorNew":"Bicara Therapeutics \/ Braidwell LP","highestDevelopmentStatusID":"6","companyTruncated":"Bicara Therapeutics \/ Braidwell LP"},{"orgOrder":0,"company":"Bicara Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Large molecule","year":"2024","type":"Not 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Find Clinical Drug Pipeline Developments & Deals by Bicara Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The net proceeds from the financing will be used to support the development of BCA101 (ficerafusp alfa) a first-in-class, bifunctional EGFR/TGF-β antibody for head and neck squamous cell carcinoma.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 16, 2024

                          Lead Product(s) : Ficerafusp Alfa,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $362.0 million

                          Deal Type : Public Offering

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                          02

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The net proceeds from the financing will be used to support the development of BCA101 (ficerafusp alfa) a first-in-class, bifunctional EGFR/TGF-β antibody for head and neck squamous cell carcinoma.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 12, 2024

                          Lead Product(s) : Ficerafusp Alfa,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Morgan Stanley

                          Deal Size : $315.0 million

                          Deal Type : Public Offering

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                          03

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : BCA101 (ficerafusp alfa), a first-in-class bifunctional EGFR/TGF-β inhibitor, investigated for frontline HPV-negative, R/M HNSCC, advanced squamous NSCLC and cutaneous squamous cell carcinoma.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 27, 2024

                          Lead Product(s) : BCA101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The proceeds will be used to support the advancement of Bicara’s lead product, BCA101, a first-in-class bifunctional EGFR/TGF-β inhibitor, for multiple cancer types including frontline HPV-negative, R/M HNSCC, advanced squamous NSCLC and cutaneous squ...

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          December 12, 2023

                          Lead Product(s) : BCA101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Braidwell LP

                          Deal Size : $165.0 million

                          Deal Type : Series C Financing

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                          05

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : The Financing will support future studies of lead program BCA101, a first-in-class EGFR / TGF-β-trap bifunctional antibody, currently in Phase 1/1b clinical development in head and neck cancer, and pipeline growth.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          March 06, 2023

                          Lead Product(s) : BCA101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Red Tree Venture Capital

                          Deal Size : $108.0 million

                          Deal Type : Series B Financing

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                          06

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : BCA356 specifically targets CAIX-expressing tumor cells, and similar to wild type IL-12 cytokine, has the potential to reduce tumor proliferation with optimal activation of additional pro-inflammatory cytokines.

                          Brand Name : BCA356

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 07, 2022

                          Lead Product(s) : BCA356

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : BCA101 is a first-in-class antibody with a unique mechanism of anti-tumor activity that has demonstrated encouraging safety, pharmacokinetic, pharmacodynamic and efficacy profiles.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 03, 2022

                          Lead Product(s) : BCA101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Study will evaluate BCA101, EGFR / TGF-β-trap bifunctional antibody in patients with head and neck squamous cell carcinoma, squamous cell carcinoma of the anal canal and cutaneous squamous cell carcinoma.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 22, 2022

                          Lead Product(s) : BCA101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Bicara’s lead program, BCA101, a first-in-class EGFR / TGFβ-trap bifunctional antibody, entered a Phase 1/2 study at leading U.S. and Canadian cancer centers in July 2020.

                          Brand Name : BCA101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          March 15, 2021

                          Lead Product(s) : BCA101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Biocon

                          Deal Size : $40.0 million

                          Deal Type : Financing

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