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    [{"orgOrder":0,"company":"BioAegis Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Recombinant human plasma gelsolin therapy","moa":"","graph1":"Infections and Infectious Diseases","graph2":"Preclinical","graph3":"BioAegis Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Infectious Diseases","amount2New":0,"dosageForm":"","sponsorNew":"BioAegis Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"BioAegis Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"BioAegis Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Recombinant human plasma 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    Find Clinical Drug Pipeline Developments & Deals by BioAegis Therapeutics

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                            01

                            BioAegis Therapeutics

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                            Lead Product(s) : Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioAegis Enrolls First Patient in Phase 2 ARDS Trial for Gelsolin

                            Details : Rhu-pGSN (gelsolin) is a recombinant protein which acts as IL-1β inhibitor. It is being evaluated for the treatment of acute respiratory distress syndrome.

                            Brand Name : Rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 17, 2024

                            Lead Product(s) : Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            BioAegis Therapeutics

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                            Lead Product(s) : Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioAegis Unveils Study of Gelsolin as Treatment for Acute Respiratory Distress Syndrome

                            Details : Rhu-pGSN (gelsolin) is a recombinant protein which acts as IL-1β inhibitor. It is being evaluated for the treatment of acute respiratory distress syndrome.

                            Brand Name : Rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            February 27, 2024

                            Lead Product(s) : Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant Human Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : BARDA

                            Deal Size : $20.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            BioAegis Therapeutics Awarded $20 Million BARDA DRIVe Contract to Advance Gelsolin, an Immune Regulator, as a ...

                            Details : The funding will be used to advance recombinant human gelsolin (rhu-pGSN), a master regulator of the innate immune system, as a treatment for patients with for moderate-to-severe acute respiratory distress syndrome (ARDS).

                            Brand Name : Rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            October 16, 2023

                            Lead Product(s) : Recombinant Human Gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : BARDA

                            Deal Size : $20.0 million

                            Deal Type : Funding

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                            04

                            BioAegis Therapeutics

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                            BioAegis Therapeutics

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                            Lead Product(s) : Plasma Gelsolin Therapy

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioAegis Therapeutics Announces FDA Clearance of IND for its ‘Inflammation Regulator Protein,’ Gelsolin, f...

                            Details : Plasma gelsolin (pGSN) is a naturally occurring human protein that is an important component of the innate immune system. Plasma gelsolin is critically depleted in ARDS patients and has been shown to address both injurious and infectious inflammation.

                            Brand Name : Plasma Gelsolin Therapy

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 26, 2023

                            Lead Product(s) : Plasma Gelsolin Therapy

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            BioAegis Therapeutics

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                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : $22.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            BioAegis Therapeutics Completes $22 Million Institutional Sale of Equity in a Non-Brokered Transaction

                            Details : This funding will accelerate the expansion of BioAegis’ pipeline with new indications as the Company pursues its US Phase 2 program in severe pneumonia. The funds will also be used to further scale up manufacturing to support the development of seconda...

                            Brand Name : rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            March 22, 2022

                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : $22.0 million

                            Deal Type : Funding

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                            06

                            BioAegis Therapeutics

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                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioAegis Therapeutics to Present “Conquering Pneumonia and Systemic Inflammation with a Human Protein,” at...

                            Details : Supplementing human gelsolin with recombinant form (rhu-pGSN) is host-directed approach to treating inflammatory and infectious diseases. Gelsolin, naturally occurring human protein that is abundant in healthy individuals, is a key component of body’s ...

                            Brand Name : rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 29, 2021

                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            BioAegis Therapeutics

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                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Researchers Discover Previously Unknown Role of BioAegis’ Therapeutic Gelsolin as Key Signaling Protein Vita...

                            Details : Recombinant human plasma gelsolin is an ancient, highly conserved human protein that is a highly abundant plasma protein in healthy individuals. Its role is to keep inflammation localized to the site of injury and to boost the body’s ability to clear p...

                            Brand Name : Gelsolin

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            September 28, 2021

                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase II

                            Sponsor : BARDA

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            BioAegis Awarded BARDA Contract to Advance Development of Gelsolin

                            Details : Rhu-pGSN is a broad-acting threat-agnostic product that improves immune cell function at sites of injury by enhancing pathogen killing while also resolving inflammation.

                            Brand Name : rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            June 30, 2021

                            Lead Product(s) : Recombinant Human Plasma Gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase II

                            Sponsor : BARDA

                            Deal Size : Undisclosed

                            Deal Type : Funding

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                            09

                            BioAegis Therapeutics

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                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant human plasma gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Study Identifies New Role of BioAegis’ ‘Inflammation Regulator’ Gelsolin Relevant for a Range of Inflamm...

                            Details : Supplementation with rhu-pGSN mitigates the observed vascular pathology. Gelsolin is non-immunosuppressive unlike current treatments to quell inflammatory cytokines.

                            Brand Name : rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            April 08, 2021

                            Lead Product(s) : Recombinant human plasma gelsolin

                            Therapeutic Area : Infections and Infectious Diseases

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            BioAegis Therapeutics

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                            Lead Product(s) : Recombinant human plasma gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BioAegis Therapeutics Expands Phase 2 COVID-19 Treatment Clinical Trial in EU for Inflammation Regulator

                            Details : The study assesses rhu-pGSN, and its ability to regulate the overactive inflammatory response often responsible for causing lung damage and death in COVID-19 patients.

                            Brand Name : rhu-pGSN

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 15, 2020

                            Lead Product(s) : Recombinant human plasma gelsolin

                            Therapeutic Area : Pulmonary/Respiratory Diseases

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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