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    [{"orgOrder":0,"company":"Biodexa Pharmaceuticals","sponsor":"Luca Szalontay","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Panobinostat lactate","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Biodexa Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Biodexa Pharmaceuticals \/ Luca Szalontay","highestDevelopmentStatusID":"6","companyTruncated":"Biodexa Pharmaceuticals \/ Luca Szalontay"},{"orgOrder":0,"company":"Biodexa Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Panobinostat lactate","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"Biodexa 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    Find Clinical Drug Pipeline Developments & Deals by Biodexa Pharmaceuticals

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                            01

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa’s MX-110 Promising in Recurrent Glioblastoma Treatment

                            Details : MTX110 is a proprietary combination of water-soluble panobinostat. It is being evaluating in the early-stage trial studies for the treatment of recurrent glioblastoma.

                            Brand Name : MTX110

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 17, 2024

                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa Provides Update On Progression Free and Overall Survival in MTX110 Study

                            Details : MTX110 is a solubilised formulation of the histone deacetylase (HDAC) inhibitor, panobinostat, which is being evaluated for the treatment of recurrent glioblastoma.

                            Brand Name : MTX110

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            October 04, 2024

                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : CPRIT

                            Deal Size : $17.0 million

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Company Pays $3M Final Match For $17M CPRIT Grant Access

                            Details : The proceeds will be used to fund company's upcoming Phase 3 registrational study of eRapa, a proprietary oral tablet formulation of rapamycin, in Familial Adenomatous Polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            September 16, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : CPRIT

                            Deal Size : $17.0 million

                            Deal Type : Funding

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                            04

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Ladenburg Thalmann & Co

                            Deal Size : $5.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            Announces Pricing of $5M Registered Direct Offering and Concurrent Private Placement

                            Details : The net proceeds will be used to advance the clinical development of eRapa (rapamycin), also known as sirolimus. It is being evaluated for treating Familial Adenomatous Polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            July 19, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Ladenburg Thalmann & Co

                            Deal Size : $5.0 million

                            Deal Type : Public Offering

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                            05

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Tolimidone

                            Therapeutic Area : Endocrinology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa Announces Health Canada Approval for Phase 2a Tolimidone in Type 1 Diabetes

                            Details : MLR-1023 (tolimidone), a selective activator of the enzyme lyn kinase which increases phosphorylation of insulin substrate 1, being developed for the treatment of type 1 diabetes.

                            Brand Name : MLR-1023

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 16, 2024

                            Lead Product(s) : Tolimidone

                            Therapeutic Area : Endocrinology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa Reports 12-Month Data from Phase 2 eRapa Trial for GI Tract Polyps

                            Details : eRapa is a proprietary oral capsule formulation of rapamycin (mTOR inhibitor), also known as sirolimus. It is being developed for treating Familial Adenomatous Polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 11, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa Reports Positive Phase 2 Results of eRapa™ in Familial Adenomatous Polyposis

                            Details : eRapa is a proprietary oral capsule formulation of rapamycin (mTOR inhibitor), also known as sirolimus. It is being developed for treating Familial Adenomatous Polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 24, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Biodexa Pharmaceuticals

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                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Sponsor : Ladenburg Thalmann

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            Biodexa Announces $7 Million of Gross Proceeds from Warrant Exercises

                            Details : The proceeds will be used to develop, manufacture, commercialize and advance the clinical potential of eRapa, an oral tablet of rapamycin and an mTOR inhibitor, for familial adenomatous polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            May 22, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Sponsor : Ladenburg Thalmann

                            Deal Size : $7.0 million

                            Deal Type : Private Placement

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                            09

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase II

                            Recipient : Emtora Biosciences

                            Deal Size : $41.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Biodexa Licenses eRapa™ for Familial Adenomatous Polyposis Treatment

                            Details : Under the agreement, Biodexa gains rights to develop and commercialize eRapa, a proprietary oral rapamycin formulation and mTOR inhibitor for the treatment of Familial Adenomatous Polyposis.

                            Brand Name : eRapa

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            April 26, 2024

                            Lead Product(s) : Sirolimus

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase II

                            Recipient : Emtora Biosciences

                            Deal Size : $41.5 million

                            Deal Type : Licensing Agreement

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                            10

                            Biodexa Pharmaceuticals

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                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Biodexa Announces Positive Phase I Results for Diffuse Midline Glioma and R&D Update

                            Details : MTX110 is a solubilised formulation of the histone deacetylase (HDAC) inhibitor, panobinostat, which is being studied in aggressive rare/orphan brain cancer, including diffuse midline glioma, or DMG.

                            Brand Name : MTX110

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 23, 2024

                            Lead Product(s) : Panobinostat lactate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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