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Inapplicable"},{"orgOrder":0,"company":"Biogen","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Oligonucleotide","year":"2020","type":"Inapplicable","leadProduct":"Tofersen","moa":"SOD1","graph1":"Nutrition and Weight Loss","graph2":"Approved FDF","graph3":"Biogen","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Nutrition & Weight Loss","amount2New":0,"dosageForm":"Intrathecal Injection","sponsorNew":"Biogen \/ Inapplicable","highestDevelopmentStatusID":"15","companyTruncated":"Biogen \/ Inapplicable"},{"orgOrder":0,"company":"Biogen","sponsor":"Ionis Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Nutrition and Weight Loss","country":"U.S.A","productType":"Oligonucleotide","year":"2021","type":"Inapplicable","leadProduct":"Tofersen","moa":"SOD1","graph1":"Nutrition and Weight Loss","graph2":"Approved 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Pharmaceuticals","pharmaFlowCategory":"D","therapeuticArea":"Rare Diseases and Disorders","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Licensing Agreement","leadProduct":"BIIB115","moa":"SMN protein synthesis","graph1":"Rare Diseases and Disorders","graph2":"Preclinical","graph3":"Biogen","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Rare Diseases","amount2New":0,"dosageForm":"","sponsorNew":"Biogen \/ Biogen","highestDevelopmentStatusID":"4","companyTruncated":"Biogen \/ Biogen"},{"orgOrder":0,"company":"Biogen","sponsor":"Xbrane Biopharma","pharmaFlowCategory":"D","therapeuticArea":"Immunology","country":"SWEDEN","productType":"Antibody-drug Conjugate","year":"2022","type":"Licensing Agreement","leadProduct":"Certolizumab Pegol","moa":"TNF 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Therapeutics","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Oligonucleotide","year":"2025","type":"Collaboration","leadProduct":"Zorevunersen Sodium","moa":"Nav1.1","graph1":"Neurology","graph2":"Phase II","graph3":"Biogen","amount2":0.55000000000000004,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Neurology","amount2New":0.55000000000000004,"dosageForm":"Intrathecal Injection","sponsorNew":"Biogen \/ Biogen","highestDevelopmentStatusID":"8","companyTruncated":"Biogen \/ Biogen"}]

Find Clinical Drug Pipeline Developments & Deals by Biogen

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                          Top Deals by Deal Size (USD bn)

                          01

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : The collaboration aims to support the development and commercialization of STK-001 (zorevunersen sodium), a potential first-in-class disease modifying medicine for the treatment of Dravet syndrome.

                          Product Name : STK-001

                          Product Type : Oligonucleotide

                          Upfront Cash : $165.0 million

                          February 18, 2025

                          Lead Product(s) : Zorevunersen Sodium

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Recipient : Stoke Therapeutics

                          Deal Size : $550.0 million

                          Deal Type : Collaboration

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                          02

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : The collaboration aims to advance the clinical development of late-stage program BIIB059 (litifilimab). It is being evaluated for the treatment of systemic lupus erythematosus.

                          Product Name : BIIB059

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          February 12, 2025

                          Lead Product(s) : Litifilimab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase III

                          Sponsor : Royalty Pharma

                          Deal Size : $250.0 million

                          Deal Type : Collaboration

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                          03

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Leqembi (lecanemab) is an IgG1 mAb directed against aggregated soluble and insoluble forms of amyloid-beta. It is now approved for alzheimer’s disease with mild cognitive impairment.

                          Product Name : Leqembi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 31, 2025

                          Lead Product(s) : Lecanemab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Eisai

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Leqembi (lecanemab) is an IgG1 mAb directed against aggregated soluble and insoluble forms of amyloid-beta. It is now approved for alzheimer’s disease with mild cognitive impairment.

                          Product Name : Leqembi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 26, 2025

                          Lead Product(s) : Lecanemab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved FDF

                          Sponsor : Eisai

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Spinraza (nusinersen) is a survival motor neuron-2 (SMN2)-directed antisense oligonucleotide indicated for the treatment of spinal muscular atrophy (SMA) in pediatric and Toddlers.

                          Product Name : Spinraza

                          Product Type : Oligonucleotide

                          Upfront Cash : Inapplicable

                          January 23, 2025

                          Lead Product(s) : Nusinersen Sodium

                          Therapeutic Area : Rare Diseases and Disorders

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Leqembi (lecanemab) is an IgG1 mAb directed against aggregated soluble and insoluble forms of amyloid-beta. It is being investigated for alzheimer’s disease with mild cognitive impairment.

                          Product Name : Leqembi

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 13, 2025

                          Lead Product(s) : Lecanemab

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase III

                          Sponsor : Eisai

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Opuviz (aflibercept) is a vascular endothelial growth factor (VEGF) inhibitor indicated for the treatment of patients with Neovascular (Wet) Age-Related Macular Degeneration

                          Product Name : Opuviz

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 18, 2024

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Recipient : Samsung Bioepis

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : Leqembi (lecanemab) selectively binds to soluble Aβ aggregates (protofibrils), as well as insoluble amyloid beta aggregates (fibrils) which are a major component of amyloid beta plaques in AD.

                          Product Name : Leqembi

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 14, 2024

                          Lead Product(s) : Lecanemab

                          Therapeutic Area : Neurology

                          Highest Development Status : Approved

                          Recipient : Eisai

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : The collaboration aims to leverage Neomorph's proprietary molecular glue discovery platform to expedite the identification and validation of new small-molecule therapeutics for Alzheimer’s disease.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 29, 2024

                          Lead Product(s) : Molecular Glue Degrader-based Therapy

                          Therapeutic Area : Neurology

                          Highest Development Status : Discovery Platform

                          Recipient : Neomorph

                          Deal Size : $1,450.0 million

                          Deal Type : Collaboration

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                          10

                          PharmScience R&D
                          Not Confirmed
                          PharmScience R&D
                          Not Confirmed

                          Details : MOR202 (felzartamab) is an investigational monoclonal antibody designed to specifically target and deplete CD38+ cells. It is being evaluated for late AMR in kidney transplant recipients.

                          Product Name : MOR202

                          Product Type : Large molecule

                          Upfront Cash : Not Applicable

                          October 09, 2024

                          Lead Product(s) : Felzartamab

                          Therapeutic Area : Immunology

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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