[{"orgOrder":0,"company":"Biosplice","sponsor":"Samil Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Licensing Agreement","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Samil Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Samil Pharmaceutical"},{"orgOrder":0,"company":"Biosplice","sponsor":"Haisco Pharmaceutical","pharmaFlowCategory":"D","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Licensing Agreement","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Haisco Pharmaceutical","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Haisco Pharmaceutical"},{"orgOrder":0,"company":"Biosplice","sponsor":"The Division of Cancer Treatment and Diagnosis","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Collaboration","leadProduct":"Cirtuvivint","moa":"CLK\/DYRK","graph1":"Oncology","graph2":"Phase I","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biosplice \/ The Division of Cancer Treatment and Diagnosis","highestDevelopmentStatusID":"6","companyTruncated":"Biosplice \/ The Division of Cancer Treatment and Diagnosis"},{"orgOrder":0,"company":"Biosplice","sponsor":"Novo Nordisk","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Endocrinology","graph2":"Preclinical","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biosplice \/ Novo Nordisk","highestDevelopmentStatusID":"4","companyTruncated":"Biosplice \/ Novo Nordisk"},{"orgOrder":0,"company":"Biosplice","sponsor":"Roskamp Institute","pharmaFlowCategory":"D","therapeuticArea":"Neurology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Funding","leadProduct":"SM07883","moa":"Undisclosed","graph1":"Neurology","graph2":"Preclinical","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Biosplice \/ Roskamp Institute","highestDevelopmentStatusID":"4","companyTruncated":"Biosplice \/ Roskamp Institute"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Inapplicable"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Cirtuvivint","moa":"CLK\/DYRK","graph1":"Oncology","graph2":"Phase I","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Biosplice \/ Inapplicable"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Cirtuvivint","moa":"||CLK\/DYRK","graph1":"Oncology","graph2":"Phase I","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Biosplice \/ Inapplicable"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Inapplicable"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Inapplicable"},{"orgOrder":0,"company":"Biosplice","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Musculoskeletal","country":"U.S.A","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"Lorecivivint","moa":"CLK2","graph1":"Musculoskeletal","graph2":"Phase III","graph3":"Biosplice","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Musculoskeletal","amount2New":0,"dosageForm":"Intra-articular Injection","sponsorNew":"Biosplice \/ Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Biosplice \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals by Biosplice

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01

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : The collaboration aims for Biosplice to expand its clinical candidate, SM08502 (cirtuvivint), as a standalone treatment and combination therapy in patients with AML and MDS.

Product Name : SM08502

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

December 09, 2024

Lead Product(s) : Cirtuvivint

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : The Division of Cancer Treatment and Diagnosis

Deal Size : Undisclosed

Deal Type : Collaboration

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02

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : The funding will support the clinical development of SM07883, a DYRK1A inhibitor currently in preclinical trials for treating tauopathies like Alzheimer’s Disease and Frontotemporal Dementia.

Product Name : SM07883

Product Type : Other Small Molecule

Upfront Cash : Undisclosed

August 03, 2024

Lead Product(s) : SM07883

Therapeutic Area : Neurology

Highest Development Status : Preclinical

Sponsor : Roskamp Institute

Deal Size : Undisclosed

Deal Type : Funding

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03

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : The collaboration combines Novo Nordisk’s expertise in diabetes and Biosplice’s research and development efforts focused on creating selective and potent DYRK inhibitors.

Product Name : Undisclosed

Product Type : Undisclosed

Upfront Cash : Undisclosed

June 13, 2024

Lead Product(s) : Undisclosed

Therapeutic Area : Endocrinology

Highest Development Status : Preclinical

Sponsor : Novo Nordisk

Deal Size : Undisclosed

Deal Type : Collaboration

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04

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : Results from the study continue to support the potential efficacy of multiple injections of SM04690 (lorecivivint) in delaying structural progression and providing symptomatic benefic.

Product Name : SM04690

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

December 15, 2022

Lead Product(s) : Lorecivivint

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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05

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : SM04690 (lorecivivint), demonstrated clinical efficacy in earlier, less structurally damaged patients, although these trials fell short of reaching statistical significance in their primary endpoints of Pain NRS (daily pain score) at week 12 with all sub...

Product Name : SM04690

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 11, 2022

Lead Product(s) : Lorecivivint

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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06

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : Cirtuvivint (SM08502) is a small-molecule inhibitor of the CDC-like kinases (CLK) and Dual-specificity tyrosine phosphorylation-regulated (DYRK) kinases that are emerging as key contributors to numerous forms of cancer.

Product Name : SM08502

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

October 09, 2022

Lead Product(s) : Cirtuvivint

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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07

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : Cirtuvivint is a small-molecule inhibitor of the CDC-like kinases (CLK) and Dual-specificity tyrosine phosphorylation-regulated (DYRK) kinases that are emerging as key contributors to numerous forms of cancer.

Product Name : SM08502

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

November 17, 2021

Lead Product(s) : Cirtuvivint,Abiraterone Acetate

Therapeutic Area : Oncology

Highest Development Status : Phase I

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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08

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : Lorecivivint has showed structural benefit, as measured by X-ray analysis of medial joint space width, 52 weeks following a single injection in the target knee. Lorecivivint has appeared safe and well-tolerated in studies to date.

Product Name : SM04690

Product Type : Other Small Molecule

Upfront Cash : $20.0 million

September 15, 2021

Lead Product(s) : Lorecivivint

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase III

Sponsor : Haisco Pharmaceutical

Deal Size : $140.0 million

Deal Type : Licensing Agreement

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09

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : Biosplice showed that study subjects dosed with 0.07 mg lorecivivint were over two times more likely to meet the criteria for OMERACT-OARSI Strict Response, a measure that includes 50% improvement in pain or function, than those on placebo at 12 weeks.

Product Name : SM04690

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

July 22, 2021

Lead Product(s) : Lorecivivint

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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10

Interphex
Not Confirmed
Interphex
Not Confirmed

Details : In this 24-week clinical trial, Biosplice’s groundbreaking knee OA drug candidate, lorecivivint, met primary endpoints of Pain NRS (daily pain measurement) at both 12 and 24-week timepoints.

Product Name : SM04690

Product Type : Other Small Molecule

Upfront Cash : Inapplicable

April 26, 2021

Lead Product(s) : Lorecivivint

Therapeutic Area : Musculoskeletal

Highest Development Status : Phase III

Sponsor : Inapplicable

Deal Size : Inapplicable

Deal Type : Inapplicable

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