11
ALL11
BiospliceYear
11
ALL3
20243
20225
2021DEALS // DEV.
11
ALL5
Deals6
DevelopmentsCountry
11
ALL11
U.S.A11
ALL1
Haisco Pharmaceutical6
Inapplicable1
Novo Nordisk1
Roskamp Institute1
Samil Pharmaceutical1
The Division of Cancer Treatment and DiagnosisTherapeutic Area
11
ALL1
Endocrinology6
Musculoskeletal1
Neurology3
OncologyStudy Phase
11
ALL6
Phase III3
Phase I2
PreclinicalDeal Type
11
ALL2
Collaboration1
Funding6
Inapplicable2
Licensing AgreementProduct Type
11
ALL10
Other Small Molecule1
UndisclosedDosage Form
11
ALL6
Intra-articular Injection1
Oral1
Oral Tablet3
UndisclosedLead Product
11
ALL3
Cirtuvivint6
Lorecivivint1
SM078831
UndisclosedTarget
11
ALL3
CLK/DYRK6
CLK22
UndisclosedLead Product(s) : Cirtuvivint
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Undisclosed
Deal Type : Collaboration
Biosplice Begins AML and MDS Trials Sponsored By National Cancer Institute
Details : The collaboration aims for Biosplice to expand its clinical candidate, SM08502 (cirtuvivint), as a standalone treatment and combination therapy in patients with AML and MDS.
Product Name : SM08502
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
December 09, 2024
Lead Product(s) : Cirtuvivint
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : SM07883
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Roskamp Institute
Deal Size : Undisclosed
Deal Type : Funding
Biosplice Receives DoD Award for Collaboration with The Roskamp Institute
Details : The funding will support the clinical development of SM07883, a DYRK1A inhibitor currently in preclinical trials for treating tauopathies like Alzheimer’s Disease and Frontotemporal Dementia.
Product Name : SM07883
Product Type : Other Small Molecule
Upfront Cash : Undisclosed
August 03, 2024
Lead Product(s) : SM07883
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Roskamp Institute
Deal Size : Undisclosed
Deal Type : Funding
Lead Product(s) : Undisclosed
Therapeutic Area : Endocrinology
Study Phase : Preclinical
Sponsor : Novo Nordisk
Deal Size : Undisclosed
Deal Type : Collaboration
Biosplice, Novo Nordisk Partner to Develop Drug Candidates for Treatment of Diabetes
Details : The collaboration combines Novo Nordisk’s expertise in diabetes and Biosplice’s research and development efforts focused on creating selective and potent DYRK inhibitors.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 13, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Endocrinology
Highest Development Status : Preclinical
Sponsor : Novo Nordisk
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Results from the study continue to support the potential efficacy of multiple injections of SM04690 (lorecivivint) in delaying structural progression and providing symptomatic benefic.
Product Name : SM04690
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
December 15, 2022
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : SM04690 (lorecivivint), demonstrated clinical efficacy in earlier, less structurally damaged patients, although these trials fell short of reaching statistical significance in their primary endpoints of Pain NRS (daily pain score) at week 12 with all sub...
Product Name : SM04690
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 11, 2022
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cirtuvivint
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Cirtuvivint (SM08502) is a small-molecule inhibitor of the CDC-like kinases (CLK) and Dual-specificity tyrosine phosphorylation-regulated (DYRK) kinases that are emerging as key contributors to numerous forms of cancer.
Product Name : SM08502
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
October 09, 2022
Lead Product(s) : Cirtuvivint
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Cirtuvivint,Abiraterone Acetate
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
First Subject Dosed in Biosplice Therapeutics Phase 1b Clinical Trial in Oncology
Details : Cirtuvivint is a small-molecule inhibitor of the CDC-like kinases (CLK) and Dual-specificity tyrosine phosphorylation-regulated (DYRK) kinases that are emerging as key contributors to numerous forms of cancer.
Product Name : SM08502
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
November 17, 2021
Lead Product(s) : Cirtuvivint,Abiraterone Acetate
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Study Phase : Phase III
Sponsor : Haisco Pharmaceutical
Deal Size : $140.0 million
Deal Type : Licensing Agreement
Details : Lorecivivint has showed structural benefit, as measured by X-ray analysis of medial joint space width, 52 weeks following a single injection in the target knee. Lorecivivint has appeared safe and well-tolerated in studies to date.
Product Name : SM04690
Product Type : Other Small Molecule
Upfront Cash : $20.0 million
September 15, 2021
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase III
Sponsor : Haisco Pharmaceutical
Deal Size : $140.0 million
Deal Type : Licensing Agreement
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Biosplice Phase 2B Lorecivivint Clinically Meaningful to Knee Osteoarthritis
Details : Biosplice showed that study subjects dosed with 0.07 mg lorecivivint were over two times more likely to meet the criteria for OMERACT-OARSI Strict Response, a measure that includes 50% improvement in pain or function, than those on placebo at 12 weeks.
Product Name : SM04690
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 22, 2021
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Study Phase : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Biosplice Publishes Successful Clinical Trial in Knee Osteoarthritis
Details : In this 24-week clinical trial, Biosplice’s groundbreaking knee OA drug candidate, lorecivivint, met primary endpoints of Pain NRS (daily pain measurement) at both 12 and 24-week timepoints.
Product Name : SM04690
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
April 26, 2021
Lead Product(s) : Lorecivivint
Therapeutic Area : Musculoskeletal
Highest Development Status : Phase III
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable