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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"BioXcel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BioXcel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"BioXcel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"Talabostat Mesylate","moa":"||DPP-8\/DPP-9","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"BioXcel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"BioXcel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BioXcel Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"BioXcel Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2023","type":"Inapplicable","leadProduct":"Talabostat Mesylate","moa":"||DPP-8\/DPP-9","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"BioXcel Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"BioXcel Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"BioXcel Therapeutics \/ Inapplicable"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : Strengthened cash position will support advancement of SERENITY trial, to evaluate BXCL501, an ODT of dexmedetomidine, for agitation associated with bipolar disorders or schizophrenia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 11, 2025

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Approved FDF

                          Sponsor : Undisclosed

                          Deal Size : $14.0 million

                          Deal Type : Financing

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                          02

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : An orally dissolving film formulation of BXCL501 (dexmedetomidine), in the at-home setting is being investigated for acute treatment of agitation associated with bipolar disorders or schizophrenia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          March 07, 2025

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Approved FDF

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          blank

                          03

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : The proceeds from the financing will be used to commercialize Igalmi (dexmedetomidine HCl). It is being indicated for the treatment of agitation associated with schizophrenia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          March 04, 2025

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Approved FDF

                          Sponsor : Rodman & Renshaw LLC

                          Deal Size : $14.0 million

                          Deal Type : Public Offering

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                          04

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : BXCL501 (dexmedetomidine Hc;) is being evaluated in the late-stage clinical trials studies for the treatment of Agitation Associated with Bipolar Disorders and Schizophrenia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 11, 2024

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase III

                          Sponsor : CSL Vifor

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : BXCL701 (talabostat mesylate) is an oral small molecule DPP inhibitor under investigation for small cell neuroendocrine prostate cancer treatment.

                          Product Name : BXCL701

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 02, 2024

                          Lead Product(s) : Talabostat Mesylate,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : BXCL501 (dexmedetomidine HCl) is an adrenergic receptor alpha-2 agonist, small molecule drug candidate, which is currently being evaluated for agitation associated With alzheimer’s dementia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 04, 2024

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Neurology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : BXCL501 (dexmedetomidine HCl) is an adrenergic receptor alpha-2 agonist, which is currently being evaluated for the treatment of Bipolar Disorder and Schizophrenia.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          September 19, 2024

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : The company will use net proceeds for ongoing clinical trials and commercialization of Igalmi (dexmedetomidine), for treating agitation associated with schizophrenia or bipolar disorder.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          August 02, 2024

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Approved FDF

                          Sponsor : BofA Securities

                          Deal Size : $60.0 million

                          Deal Type : Public Offering

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                          09

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : Igalmi (dexmedetomidine) sublingual film is being evaluated in late-stage clinical trial studies for the treatment of agitation associated with schizophrenia or bipolar I or II disorder.

                          Product Name : Igalmi

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 25, 2024

                          Lead Product(s) : Dexmedetomidine Hydrochloride

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          World Vaccine Conference
                          Not Confirmed
                          World Vaccine Conference
                          Not Confirmed

                          Details : BXCL701 (talabostat mesylate) is an oral innate immune activator evaluated in phase 2 clinical trials in combination with Keytruda for treating metastatic pancreatic ductal adenocarcinoma.

                          Product Name : BXCL701

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 02, 2024

                          Lead Product(s) : Talabostat Mesylate,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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