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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : MSRD will finance key non-human primate studies for the pre-clinical development of BITT’s CD40 antagonist, BITD401412, in autoimmune diseases, including autoimmune thyroiditis, T1D & IBD.

                          Brand Name : BITD401412

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 16, 2024

                          Lead Product(s) : BITD401412

                          Therapeutic Area : Immunology

                          Highest Development Status : IND Enabling

                          Sponsor : MSRD

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          02

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : The funding will support the preclinical development of BITT’s BITT-101, a novel dominant CD40 antagonist antibody for use in the treatment of Sjögren’s Syndrome.

                          Brand Name : BITT-101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          August 31, 2023

                          Lead Product(s) : BITT-101

                          Therapeutic Area : Immunology

                          Highest Development Status : Preclinical

                          Sponsor : National Institutes of Health

                          Deal Size : Undisclosed

                          Deal Type : Funding

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                          03

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : BITT2101 is an investigational, novel, tumor necrosis factor superfamily receptor (TNFSR) antagonist antibody, which is being investigated for the treatment in patients with relapsed or refractory Non-Hodgkin’s lymphomas.

                          Brand Name : BITT2101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          August 18, 2023

                          Lead Product(s) : BITT2101

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : BITT-CD4D11 and BITT-CD4F10, CD40 antagonists, are being developed for indications in autoimmunity and inflammation including Crohn’s disease, inflammatory bowel disease, psoriasis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus...

                          Brand Name : BITT-CD4D11

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          February 13, 2023

                          Lead Product(s) : BITT-CD4D11

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : The agreement focuses to develop the cell line for BITR2101, BITT’s lead tumor necrosis factor receptor 2 (TNFR2) antagonist antibody for the treatment of cancers and infectious diseases.

                          Brand Name : BITR2101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          March 09, 2021

                          Lead Product(s) : BITR2101

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Recipient : KBI Biopharma

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          PharmaVenue
                          Not Confirmed
                          PharmaVenue
                          Not Confirmed

                          Details : BeiGene has secured an option to an exclusive license to develop, manufacture, and commercialize BITT’s TNFR2 antagonist antibodies in Asia (ex-Japan), Australia, and New Zealand. Parties plan to conduct Phase 1 trials of BITR2101 and combination studi...

                          Brand Name : BITR2101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          February 17, 2021

                          Lead Product(s) : BITR2101,Tislelizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : BeiGene

                          Deal Size : $125.6 million

                          Deal Type : Collaboration

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