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Co.","highestDevelopmentStatusID":"12","companyTruncated":"Bluebird Bio \/ Goldman Sachs & Co."},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Goldman Sachs","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Public Offering","leadProduct":"Idecabtagene Vicleucel","moa":"","graph1":"Oncology","graph2":"Approved","graph3":"2Seventy Bio","amount2":0.13,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Oncology","amount2New":0.13,"dosageForm":"Infusion","sponsorNew":"2Seventy Bio \/ Goldman Sachs","highestDevelopmentStatusID":"12","companyTruncated":"2Seventy Bio \/ Goldman Sachs"},{"orgOrder":0,"company":"2Seventy Bio","sponsor":"Bristol Myers Squibb","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Not Applicable","leadProduct":"Idecabtagene 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                          Top Deals by Deal Size (USD bn)

                          01

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy which binds to BCMA on the surface of multiple myeloma cells. It is being evaluated for newly diagnosed multiple myeloma.

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 25, 2024

                          Lead Product(s) : Idecabtagene Vicleucel,Lenalidomide,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bristol Myers Squibb

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Novo has acquired the Hemophilia A program and rights to 2seventy’s in vivo gene editing technology for autologous or allogeneic cell therapies of immune cells for the treatment of autoimmune disease.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          June 26, 2024

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Preclinical

                          Sponsor : Novo Nordisk

                          Deal Size : $40.0 million

                          Deal Type : Divestment

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                          03

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy for multiple myeloma, approved for treating triple-class exposed relapsed or refractory patients.

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          April 05, 2024

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Bristol Myers Squibb

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Proceeds will fund commercial launches of FDA-approved gene therapies, including Lyfgenia for sickle cell disease, Zynteglo for beta-thalassemia, and Skysona for cerebral adrenoleukodystrophy.

                          Brand Name : Lyfgenia

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 18, 2024

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved

                          Sponsor : Hercules Capital

                          Deal Size : Undisclosed

                          Deal Type : Financing

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                          05

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Bluebird Bio will commercialize Lyfgenia (lovotibeglogene autotemcelsickle) for sickle cell disease patients with vaso-occlusive events.

                          Brand Name : Lyfgenia

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          March 11, 2024

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved

                          Sponsor : Medicaid

                          Deal Size : Undisclosed

                          Deal Type : Agreement

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                          06

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Regeneron will have full development and commercialization rights to its pipeline of investigational immune cell therapies, including Abecma (idecabtagene vicleucel).

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $5.0 million

                          January 30, 2024

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Acquisition

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                          07

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : bluebird will support commercialization and manufacturing for its three approved gene therapies, Zynteglo (betibeglogene autotemcel) for beta-thalassemia, Skysona (elivaldogene autotemcel) and Lyfgenia (lovotibeglogene autotemcel) for sickle cell disease...

                          Brand Name : Zynteglo

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Undisclosed

                          December 18, 2023

                          Lead Product(s) : Betibeglogene Autotemcel

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Approved

                          Sponsor : Goldman Sachs & Co. LLC

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          08

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a BCMA directed CAR-T cell immunotherapy, for patients with relapsed or refractory multiple myeloma (RRMM) who have received at least two prior therapies, including an immunomodulatory agent, a proteasome inhibitor, and...

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 11, 2023

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Recipient : Bristol Myers Squibb

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : FDA approved, Casgevy(exagamglogene autotemcel) and Lyfgenia(lovotibeglogene autotemcel), representing the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older.

                          Brand Name : Lyfgenia

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 08, 2023

                          Lead Product(s) : Lovotibeglogene Autotemcel

                          Therapeutic Area : Hematology

                          Highest Development Status : Approved

                          Recipient : Vertex Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy that recognizes and binds to BCMA on the surface of multiple myeloma cells, for earlier lines of triple-class exposed relapsed or refractory multiple myeloma (RRMM).

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 20, 2023

                          Lead Product(s) : Idecabtagene Vicleucel

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Recipient : Bristol Myers Squibb

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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