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Find Clinical Drug Pipeline Developments & Deals by BlueSphere Bio

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            Development Status

            Details:

            Through this partnership, BlueSphere will focus on the clinical development of lead product, BSB-1001 for treating patients with relapsed or refractory acute myeloid leukemia.

            Lead Product(s): BSB-1001

            Therapeutic Area: Oncology Product Name: BSB-1001

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: NMDP BioTherapies

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership June 25, 2024

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            Details:

            The collaboration will seek to advance a novel TCR T-cell therapy, TCX-201, targeting recurrent respiratory papillomatosis (RRP), a rare orphan disease.

            Lead Product(s): TCR T-cell Therapy

            Therapeutic Area: Rare Diseases and Disorders Product Name: Undisclosed

            Highest Development Status: Approved Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: National Cancer Institute

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration June 04, 2024

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            Details:

            BSB-1001 is an investigational T cell receptor (TCR) T-cell therapy developed by BlueSphere Bio. It is baing evaluated for the treatment of acute myeloid leukemia (AML).

            Lead Product(s): BSB-1001

            Therapeutic Area: Oncology Product Name: BSB-1001

            Highest Development Status: Phase I Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 03, 2024

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            Details:

            BSB-1001, targeting the minor HA-1 and part of BlueSphere’s TCX-101 Program, is the first TCR-based clinical candidate generated using TCXpress and is in development for the treatment of AML, ALL and MDS in conjunction with allogeneic hematopoietic stem cell transplantation.

            Lead Product(s): BSB-1001

            Therapeutic Area: Oncology Product Name: BSB-1001

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 01, 2023

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            Details:

            TCX-101 program targets minor histocompatibility antigens by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic stem cell transplant.

            Lead Product(s): TCX – 101

            Therapeutic Area: Oncology Product Name: TCX – 101

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 26, 2022

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            Details:

            TCX-101 program targets minor histocompatibility antigens by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic stem cell transplant.

            Lead Product(s): TCX – 101

            Therapeutic Area: Oncology Product Name: TCX – 101

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 19, 2022

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            Details:

            TCX-101, is a proprietary high-throughput and efficient T-cell receptor (TCR) capture, expression and functional screening platform capable of processing thousands of single T cells directly into functionally expressed TCRs.

            Lead Product(s): TCX-101

            Therapeutic Area: Oncology Product Name: TCX-101

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 25, 2022

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            Details:

            Preclinical data demonstrating the potential of its novel high throughput TCXpress™ platform to efficiently identify TCRs against minor histocompatibility antigens (miHAs) for the future clinical development of adoptive TCR T cell therapy.

            Lead Product(s): TCX-101

            Therapeutic Area: Oncology Product Name: TCX-101

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 08, 2022

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            Details:

            TCX-101 program targets minor histocompatibility antigens (miHAs) by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic stem cell transplant.

            Lead Product(s): TCX-101

            Therapeutic Area: Oncology Product Name: TCX-101

            Highest Development Status: IND Enabling Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 15, 2022

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