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    [{"orgOrder":0,"company":"BlueSphere Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"TCX-101","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"BlueSphere Bio","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"BlueSphere Bio \/ Not Applicable","highestDevelopmentStatusID":"4","companyTruncated":"BlueSphere Bio \/ Not Applicable"},{"orgOrder":0,"company":"BlueSphere Bio","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"TCX-101","moa":"","graph1":"Oncology","graph2":"Preclinical","graph3":"BlueSphere 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    Find Clinical Drug Pipeline Developments & Deals by BlueSphere Bio

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                            01

                            BlueSphere Bio

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                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : NMDP BioTherapies

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            BlueSphere Bio Partners with NMDP BioTherapies for TCR-based Product Candidate Trial

                            Details : Through this partnership, BlueSphere will focus on the clinical development of lead product, BSB-1001 for treating patients with relapsed or refractory acute myeloid leukemia.

                            Brand Name : BSB-1001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 25, 2024

                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : NMDP BioTherapies

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            02

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                            Lead Product(s) : TCR T-cell Therapy

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Discovery

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            BlueSphere Collaborates with NCI to Advance Rare Respiratory Disease Treatments

                            Details : The collaboration will seek to advance a novel TCR T-cell therapy, TCX-201, targeting recurrent respiratory papillomatosis (RRP), a rare orphan disease.

                            Brand Name : Undisclosed

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            June 04, 2024

                            Lead Product(s) : TCR T-cell Therapy

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Discovery

                            Sponsor : National Cancer Institute

                            Deal Size : Undisclosed

                            Deal Type : Collaboration

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                            03

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                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            BlueSphere Bio Gets IND Clearance for First in Human Candidate in Leukemia

                            Details : BSB-1001 is an investigational T cell receptor (TCR) T-cell therapy developed by BlueSphere Bio. It is baing evaluated for the treatment of acute myeloid leukemia (AML).

                            Brand Name : BSB-1001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            June 03, 2024

                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

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                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BlueSphere Bio to Present at the Next Generation CAR & T Cell Therapies Conference

                            Details : BSB-1001, targeting the minor HA-1 and part of BlueSphere’s TCX-101 Program, is the first TCR-based clinical candidate generated using TCXpress and is in development for the treatment of AML, ALL and MDS in conjunction with allogeneic hematopoietic ste...

                            Brand Name : BSB-1001

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 01, 2023

                            Lead Product(s) : BSB-1001

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            BlueSphere Bio

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                            Lead Product(s) : TCX – 101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BlueSphere Bio Presents Data Demonstrating Efficiency of Parallel TCR Capture and Bioinformatics Platforms at ...

                            Details : TCX-101 program targets minor histocompatibility antigens by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic stem ce...

                            Brand Name : TCX – 101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 26, 2022

                            Lead Product(s) : TCX – 101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : TCX – 101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BlueSphere Bio to Present at the 7th Annual CAR-TCR Summit

                            Details : TCX-101 program targets minor histocompatibility antigens by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic stem ce...

                            Brand Name : TCX – 101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            September 19, 2022

                            Lead Product(s) : TCX – 101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

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                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            BlueSphere Bio Data to be Presented at the 2022 Joint ASTCT + EBMT Basic and Translational Scientific Retreat

                            Details : TCX-101, is a proprietary high-throughput and efficient T-cell receptor (TCR) capture, expression and functional screening platform capable of processing thousands of single T cells directly into functionally expressed TCRs.

                            Brand Name : TCX-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            May 25, 2022

                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

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                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            BlueSphere Bio Presents New Data Supporting the Potential of its TCXpress Platform at the 2022 AACR Meeting

                            Details : Preclinical data demonstrating the potential of its novel high throughput TCXpress™ platform to efficiently identify TCRs against minor histocompatibility antigens (miHAs) for the future clinical development of adoptive TCR T cell therapy.

                            Brand Name : TCX-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 08, 2022

                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

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                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            BlueSphere Bio Data to be Presented at the 2022 American Association for Cancer Research Annual Meeting

                            Details : TCX-101 program targets minor histocompatibility antigens (miHAs) by engineering TCR T cells specific to a particular miHA. This allows for achieving graft-vs.-leukemia (GVL) with a lower risk for graft-vs.-host disease (GVHD) in allogeneic hematopoietic...

                            Brand Name : TCX-101

                            Molecule Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            March 15, 2022

                            Lead Product(s) : TCX-101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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