Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TRK-950,Ramucirumab,Paclitaxel
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Toray Industries
Deal Size : Undisclosed
Deal Type : Collaboration
Bolt Biotherapeutics Updates Cancer Immunotherapy Co-Development with Toray
Details : The collaboration aims to develop TRK-950, an Caprin-1 designed to target multiple solid tumor types. Currently, it is being evaluated for the treatment of gastric cancer.
Product Name : TRK-950
Product Type : Antibody
Upfront Cash : Undisclosed
February 11, 2025
Lead Product(s) : TRK-950,Ramucirumab,Paclitaxel
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Toray Industries
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : BDC-1001,Pertuzumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : BDC-1001 is an investigational immune-stimulating antibody conjugate (ISAC), which is being developed for the treatment of patients with HER2-Positive Breast Cancer.
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
December 05, 2023
Lead Product(s) : BDC-1001,Pertuzumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : BDC-3042,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : BDC-3042, a novel Dectin-2 agonistic antibody that stimulates the innate immune system, is being evaluated in a Phase 1/2 dose-escalation and expansion study in patients with a broad range of solid tumors.
Product Name : BDC-3042
Product Type : Large molecule
Upfront Cash : Not Applicable
October 17, 2023
Lead Product(s) : BDC-3042,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Bolt Biotherapeutics Receives Orphan Drug Designation for BDC-1001 for Treatment of Gastric Cancers
Details : BDC-1001 is an investigational immune-stimulating antibody conjugate (ISAC), which is being developed for the treatment of patients with gastric cancer, including gastroesophageal junction cancer.
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
September 28, 2023
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : BDC-1001 is a Boltbody™ Immune-Stimulating Antibody Conjugate comprising a HER2-targeting biosimilar of trastuzumab conjugated with a non-cleavable linker to a proprietary TLR7/8 agonist, in development forHER2-positive colorectal, endometrial and gast...
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
August 03, 2023
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : BDC-1001 is an investigational immune-stimulating antibody conjugate (ISAC), which is being developed for the treatment of patients with HER2-expressing cancer.
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
March 29, 2023
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : F. Hoffmann-La Roche
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : BDC-1001,Pertuzumab
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the agreement, Roche will provide pertuzumab in support of a Phase 2 metastatic breast cancer trial to evaluate pertuzumab in combination with BDC-1001.
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Undisclosed
March 29, 2023
Lead Product(s) : BDC-1001,Pertuzumab
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : F. Hoffmann-La Roche
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Bolt is developing a pipeline of myeloid-targeting therapies, including BDC-1001, immune-stimulating antibody conjugates (ISACs) and BDC-3042 (a Dectin-2 agonistic antibody), designed to kill tumors through activation of myeloid cells and subsequent recr...
Product Name : BDC-1001
Product Type : Antibody-drug Conjugate
Upfront Cash : Inapplicable
May 27, 2022
Lead Product(s) : BDC-1001,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : BDC-2034
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Three of Bolt Biotherapeutics’ preclinical programs will be featured in presentation: (1) BDC-2034, a CEA-targeting immune-stimulating antibody conjugate (2) BDC-3042, a Dectin-2-targeting, myeloid-modulating antibody, and (3) a PD-L1-targeting ISAC.
Product Name : BDC-2034
Product Type : Large molecule
Upfront Cash : Not Applicable
March 08, 2022
Lead Product(s) : BDC-2034
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Trastuzumab-TLR7/8 conjugate,Nivolumab
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Bristol Myers Squibb
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Initial safety and early efficacy findings reported from the ongoing monotherapy arm of the Phase 1/2 clinical trial make BDC-1001 (Trastuzumab-TLR7/8 conjugate) a potentially promising candidate for the treatment of patients with HER2 in combination wit...
Product Name : BDC-1001
Product Type : Large molecule
Upfront Cash : Not Applicable
January 06, 2022
Lead Product(s) : Trastuzumab-TLR7/8 conjugate,Nivolumab
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Bristol Myers Squibb
Deal Size : Not Applicable
Deal Type : Not Applicable