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Launches First-to-Market Authorized Generic Version of Combigan\u00ae Ophthalmic Solution in the United States","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Approved","country":"","productType":"Small molecule","productStatus":"Approved","date":"January 2022","year":"2022","type":"Not Applicable","leadProduct":"Brimonidine Tartrate","moa":"Adrenergic receptor alpha-2","url1":"","url2":"","graph1":"Ophthalmology","graph2":"Approved","graph3":"Apotex Fermentation Inc.","amount2":0,"therapeuticAreaNew":"Ophthalmology","highestDevelopmentStatusNew":"Approved","highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Ophthalmology","productSubType":"Small molecule","amount2New":0,"dosageForm":"Ophthalmic Suspension","sponsorNew":"Apotex Fermentation Inc. \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Apotex Fermentation Inc. \/ Not Applicable"},{"orgOrder":0,"company":"Visus Therapeutics","sponsor":"Not 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U.S.","therapeuticArea":"Ophthalmology","highestDevelopmentStatus":"Phase III","country":"","productType":"Small molecule","productStatus":"Approved","date":"July 2022","year":"2022","type":"Licensing Agreement","leadProduct":"Brimonidine Tartrate","moa":"Adrenergic receptor alpha-2","url1":"","url2":"","graph1":"Ophthalmology","graph2":"Phase III","graph3":"Slayback Pharma","amount2":0,"therapeuticAreaNew":"Ophthalmology","highestDevelopmentStatusNew":"Phase III","highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Ophthalmology","productSubType":"Small molecule","amount2New":0,"dosageForm":"Solution","sponsorNew":"Slayback Pharma \/ Dr. Reddy\u2019s Laboratories","highestDevelopmentStatusID":"10","companyTruncated":"Slayback Pharma \/ Dr. Reddy\u2019s Laboratories"},{"orgOrder":0,"company":"LENZ Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","amount":"Not Applicable","upfrontCash":"Not Applicable","newsHeadline":"LENZ Therapeutics Announces Positive 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Not Applicable"}]

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                          01

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : Brimonidine tartrate ophthalmic solution is an alpha adrenergic receptor agonist, indicated for treatment patients with open-angle glaucoma or ocular hypertension.

                          Brand Name : Alphagan P-Generic

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 28, 2024

                          Lead Product(s) : Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : The net proceeds will be used to fund the clinical advancement of LNZ100 (aceclidine & brimonidine tartrate), which is being evaluated in the late-stage clinical trial for the treatment of Presbyopia.

                          Brand Name : LNZ100

                          Molecule Type :

                          Upfront Cash : Undisclosed

                          July 15, 2024

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Ridgeback Capital

                          Deal Size : $30.0 million

                          Deal Type : Private Placement

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                          03

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : LNZ101 is a fixed dose opthalmic solution of aceclidine (mAChRs agonist) & brimonidine (ADRA2 agonist), which is being evaluated for the treatment of presbyopia.

                          Brand Name : LNZ101

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 03, 2024

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : The net proceeds will advance LENZ’s lead programs, LNZ100 and LNZ101, preservative-free, single-use, once-daily eye drops for treating presbyopia.

                          Brand Name : LNZ101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 21, 2024

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Versant Ventures

                          Deal Size : $53.5 million

                          Deal Type : Private Placement

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                          05

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : The collaboration will advance LENZ’s lead programs, LNZ100 and LNZ101, preservative-free eye drops containing aceclidine and aceclidine plus brimonidine for presbyopia treatment.

                          Brand Name : LNZ101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          March 21, 2024

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Graphite Bio

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          06

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : The combined will focus on the advancement of LENZ’s lead programs, LNZ100 and LNZ101, which are preservative-free, single-use, once-daily eye drops containing aceclidine and aceclidine plus brimonidine, respectively, for the treatment of presbyopia.

                          Brand Name : LNZ101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 15, 2023

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : LENZ Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          07

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : The net proceeds will be used on the advancement of LENZ’s lead programs, LNZ100 and LNZ101, which are preservative-free, single-use, once-daily eye drops containing aceclidine and aceclidine plus brimonidine, respectively, for the treatment of presbyo...

                          Brand Name : LNZ101

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          November 15, 2023

                          Lead Product(s) : Aceclidine Hydrochloride,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Versant Ventures

                          Deal Size : $53.5 million

                          Deal Type : Private Placement

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                          08

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : Brimocholâ„¢ PF (combination of carbachol and brimonidine tartrate) is a preservative-free topical ophthalmic solution which is used to lower pressure in the eyes, it is being investigated for the treatment of presbyopia.

                          Brand Name : Brimochol

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 20, 2023

                          Lead Product(s) : Carbachol,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : Brimonidine Tartrate is an Ophthalmic Solution, 0.15%, Of Abbvie Inc.a n Alpha Adrenergic Receptor Agonist, The Drug is Indicated for treatment of Elevated Intraocular Pressure in Patients With Open-Angle Glaucoma Or Ocular Hypertension.

                          Brand Name : Alphagan P-Generic

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 30, 2023

                          Lead Product(s) : Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          AAPS 2024
                          Not Confirmed
                          AAPS 2024
                          Not Confirmed

                          Details : Brimocholâ„¢ PF (combination of carbachol and brimonidine tartrate) is a preservative-free topical ophthalmic solution which is used to lower pressure in the eyes, it is being investigated for the treatment of presbyopia.

                          Brand Name : Brimochol

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          March 22, 2023

                          Lead Product(s) : Carbachol,Brimonidine Tartrate

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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