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                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Opdivo (nivolumab) in combination with Yervoy (ipilimumab) is being evaluated for the treatment of microsatellite instability–high or mismatch repair deficient metastatic colorectal cancer.

                          Brand Name : Opdivo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 15, 2024

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Prime Medicine will design optimized Prime Editor reagents for a select number of targets, including reagents that use its Prime Assisted Site-Specific Integrase Gene Editing (PASSIGE™) technology.

                          Brand Name : Undisclosed

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : $110.0 million

                          September 30, 2024

                          Lead Product(s) : T-Cell-based Therapy

                          Therapeutic Area : Hematology

                          Highest Development Status : Preclinical

                          Recipient : Prime Medicine

                          Deal Size : $3,610.0 million

                          Deal Type : Collaboration

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                          03

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Abecma (idecabtagene vicleucel) is a CAR T cell therapy which binds to BCMA on the surface of multiple myeloma cells. It is being evaluated for newly diagnosed multiple myeloma.

                          Brand Name : Abecma

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          September 25, 2024

                          Lead Product(s) : Idecabtagene Vicleucel,Lenalidomide,Fludarabine Phosphate

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : 2Seventy Bio

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Camzyos (mavacamten) is a cardiac myosin inhibitor, indicated for the treatment of adults with class II-III symptomatic obstructive hypertrophic cardiomyopathy.

                          Brand Name : Camzyos

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          September 01, 2024

                          Lead Product(s) : Mavacamten

                          Therapeutic Area : Cardiology/Vascular Diseases

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Combination of Opdivo (nivolumab) and Yervoy(Ipilimumab) met the main goal of a late-stage study evaluating it as an initial treatment for patients with advanced hepatocellular carcinoma.

                          Brand Name : Opdivo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          July 19, 2024

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : With the termination of its agreement with BMS, Eisai will solely focus on the development & commercialization of MORAb-202 (farletuzumab ecteribulin), is being evaluated for the treatment of NSCLC.

                          Brand Name : MORAb-202

                          Molecule Type : Large molecule

                          Upfront Cash : $650.0 million

                          July 01, 2024

                          Lead Product(s) : Farletuzumab Ecteribulin

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Recipient : Eisai

                          Deal Size : $3,100.0 million

                          Deal Type : Termination

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                          07

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : KRAZATI (adagrasib), a potent oral small-molecule inhibitor of KRASG12C, is indicated in combination with cetuximab for patients with locally advanced or metastatic colorectal cancer.

                          Brand Name : Krazati

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 21, 2024

                          Lead Product(s) : Adagrasib,Cetuximab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Combination of Opdivo (nivolumab) and Yervoy(Ipilimumab) met the main goal of a late-stage study evaluating it as an initial treatment for patients with advanced hepatocellular carcinoma.

                          Brand Name : Opdivo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 04, 2024

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Opdivo (Nivolumab) and Yervoy (Ipilimumab) IV infusion, when given prior to surgery whose skin cancer had spread to lymph nodes, had better outcomes than those who did not get the drugs.

                          Brand Name : Opdivo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 03, 2024

                          Lead Product(s) : Nivolumab,Ipilimumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Netherlands Cancer Institute

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          Antibody Engineering
                          Not Confirmed
                          Antibody Engineering
                          Not Confirmed

                          Details : Opdivo (nivolumab) is a PD-1 immune checkpoint inhibitor, which is approved in combination with cisplatin and gemcitabine, for the patients with unresectable or metastatic urothelial carcinoma.

                          Brand Name : Opdivo

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          May 29, 2024

                          Lead Product(s) : Nivolumab,Cisplatin,Gemcitabine

                          Therapeutic Area : Oncology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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