Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
vTv Therapeutics Cadisegliatin Program for Type 1 Diabetes Placed on Clinical Hold
Details : TTP399 (cadisegliatin) is an investigational liver-selective glucokinase activator that has been studied in healthy volunteers and in patients with type 1 and type 2 diabetes.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 26, 2024
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
vTv Announces Screening of First Patient in CATT1 Trial for Type 1 Diabetes
Details : TTP399 (cadisegliatin) is a novel, oral small molecule, liver-selective glucokinase activator with first-in-class potential as an adjunct treatment for type 1 diabetes.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 24, 2024
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
vTv Submits FDA Application for First Phase 3 Study of Cadisegliatin in Type 1 Diabetes
Details : TTP399 (cadisegliatin) is an investigational liver-selective glucokinase activator that has been studied in healthy volunteers and in patients with type 1 and type 2 diabetes.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 04, 2024
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : Samsara BioCapital, LLC
Deal Size : $51.0 million
Deal Type : Private Placement
vTv Therapeutics Announces $51 Million Private Placement
Details : vTv will utilize the net proceeds to finance the initial Phase 3 trial of its primary product candidate, TTP399 (cadisegliatin), a glucokinase activator intended for treating type 1 diabetes.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Undisclosed
February 28, 2024
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : Samsara BioCapital, LLC
Deal Size : $51.0 million
Deal Type : Private Placement
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Reneo Pharmaceuticals
Deal Size : $4.4 million
Deal Type : Agreement
vTv Therapeutics Announces Sale of Shares in Reneo Pharmaceuticals for Proceeds of $4.4 Million
Details : The proceeds will provide vTv with important financial support for preparing the launch of the TTP399 (cadisegliatin), a potential adjunctive therapy to insulin, phase 3 program in the treatment of type 1 diabetes.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 01, 2023
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Reneo Pharmaceuticals
Deal Size : $4.4 million
Deal Type : Agreement
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : CinPax
Deal Size : $10.0 million
Deal Type : Agreement
vTv Therapeutics Announces Investment by CinRx Pharma
Details : In addition to the investment, the agreements set forth the terms under which vTv will leverage the CinRx team’s industry experience to collaborate on the oversight of the clinical trials for pharmaceutical products that contain TTP399.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : $6.0 million
July 25, 2022
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : CinPax
Deal Size : $10.0 million
Deal Type : Agreement
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Results confirmed TTP399 improves glycemia without increasing hypoglycemia and suggest a protective effect of TTP399 against DKA in individuals with T1D.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 04, 2022
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase II
Sponsor : G42 Investments
Deal Size : $55.0 million
Deal Type : Collaboration
Details : The agreements set forth the terms under which vTv and an affiliate of G42 plan to collaborate on clinical trials for pharmaceutical products that contain TTP399, including G42’s affiliate funding a portion of the Phase 3 clinical trials for TTP399.
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : $12.5 million
June 01, 2022
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase II
Sponsor : G42 Investments
Deal Size : $55.0 million
Deal Type : Collaboration
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
vTv Therapeutics Shares Updated Corporate Presentation
Details : TTP399, a novel oral liver-selective glucokinase activator, as a transformative treatment in the reduction of hypoglycemic episodes for the global diabetes population, has been tested in almost 600 patients to date with no evidence of diabetic ketoacidos...
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 13, 2022
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The Breakthrough Therapy designation for TTP399 in type 1 diabetes was supported by the recent positive results from the phase 2 SimpliciT-1 study assessing the safety and efficacy of TTP399 as an adjunct to insulin therapy in adults with type 1 diabetes...
Brand Name : TTP399
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 13, 2021
Lead Product(s) : Cadisegliatin
Therapeutic Area : Endocrinology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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