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                          Top Deals by Deal Size (USD bn)

                          01

                          PackExpo
                          Not Confirmed
                          PackExpo
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                          Details : Caelum was acquired by AstraZeneca pursuant to the developing and commercializing biopharmaceutical products and product candidates cost-effectively including Caelum’s lead asset, CAEL-101, is a novel antibody for the treatment of patients with light c...

                          Brand Name : CAEL-101

                          Molecule Type : Large molecule

                          Upfront Cash : $150.0 million

                          October 06, 2021

                          Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : $350.0 million

                          Deal Type : Acquisition

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                          02

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : AstraZeneca will accelerate ongoing Phase III clinical development of CAEL-101, a potential first-in-class medicine which is being evaluated in the Cardiac Amyloid Reaching for Extended Survival Phase III clinical programme in combination with standard-o...

                          Brand Name : CAEL-101

                          Molecule Type : Large molecule

                          Upfront Cash : Undisclosed

                          September 29, 2021

                          Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : AstraZeneca

                          Deal Size : $500.0 million

                          Deal Type : Acquisition

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                          03

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : An e-poster featuring the first data from a new arm of the study demonstrated that CAEL-101 administered in combination with cyclophosphamide-bortezomib-dexamethasone (CyBorD) plus daratumumab was generally safe and well-tolerated in the first four weeks...

                          Brand Name : CAEL-101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          June 11, 2021

                          Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Alexion Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          PackExpo
                          Not Confirmed
                          PackExpo
                          Not Confirmed

                          Details : Accepted abstracts include Phase 2 safety, efficacy, and tolerability data for CAEL-101 in AL amyloidosis. Data, from Caelum, that further shows safety and tolerability of CAEL-101 and support the selection of the 1000 mg/m2 dose for the Phase 3 study wi...

                          Brand Name : CAEL-101

                          Molecule Type : Large molecule

                          Upfront Cash : Not Applicable

                          November 04, 2020

                          Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                          Therapeutic Area : Genetic Disease

                          Highest Development Status : Phase III

                          Sponsor : Alexion Pharmaceuticals

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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