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    [{"orgOrder":0,"company":"Caelum Biosciences","sponsor":"Alexion Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"Bortezomib","moa":"","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Caelum Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous infusion","sponsorNew":"Caelum Biosciences \/ Alexion Pharmaceuticals, Inc.","highestDevelopmentStatusID":"10","companyTruncated":"Caelum Biosciences \/ Alexion Pharmaceuticals, Inc."},{"orgOrder":0,"company":"Caelum Biosciences","sponsor":"Alexion Pharmaceuticals","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2021","type":"Not Applicable","leadProduct":"Bortezomib","moa":"","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Caelum Biosciences","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Caelum Biosciences \/ Alexion","highestDevelopmentStatusID":"10","companyTruncated":"Caelum Biosciences \/ Alexion"},{"orgOrder":0,"company":"Caelum Biosciences","sponsor":"AstraZeneca","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2021","type":"Acquisition","leadProduct":"Bortezomib","moa":"","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Caelum Biosciences","amount2":0.5,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.5,"dosageForm":"Sterile Solution","sponsorNew":"Caelum Biosciences \/ AstraZeneca","highestDevelopmentStatusID":"10","companyTruncated":"Caelum Biosciences \/ AstraZeneca"},{"orgOrder":0,"company":"Caelum Biosciences","sponsor":"AstraZeneca","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Large molecule","year":"2021","type":"Acquisition","leadProduct":"Bortezomib","moa":"","graph1":"Genetic Disease","graph2":"Phase III","graph3":"Caelum Biosciences","amount2":0.34999999999999998,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Genetic Disease","amount2New":0.5,"dosageForm":"Sterile Solution","sponsorNew":"Caelum Biosciences \/ AstraZeneca","highestDevelopmentStatusID":"10","companyTruncated":"Caelum Biosciences \/ AstraZeneca"}]

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                            Caelum Biosciences

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                            Caelum Biosciences

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                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : $350.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Fortress Biotech Announces Closing of Acquisition of Caelum Biosciences by AstraZeneca

                            Details : Caelum was acquired by AstraZeneca pursuant to the developing and commercializing biopharmaceutical products and product candidates cost-effectively including Caelum’s lead asset, CAEL-101, is a novel antibody for the treatment of patients with light c...

                            Brand Name : CAEL-101

                            Molecule Type : Large molecule

                            Upfront Cash : $150.0 million

                            October 06, 2021

                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : $350.0 million

                            Deal Type : Acquisition

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                            02

                            Caelum Biosciences

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                            Caelum Biosciences

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                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : $500.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Astra Zeneca to Fully Acquire Caelum Biosciences

                            Details : AstraZeneca will accelerate ongoing Phase III clinical development of CAEL-101, a potential first-in-class medicine which is being evaluated in the Cardiac Amyloid Reaching for Extended Survival Phase III clinical programme in combination with standard-o...

                            Brand Name : CAEL-101

                            Molecule Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 29, 2021

                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : AstraZeneca

                            Deal Size : $500.0 million

                            Deal Type : Acquisition

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                            03

                            Caelum Biosciences

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                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Alexion Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Caelum and Alexion Present Additional Phase 2 Data Reinforcing Safety and Tolerability of CAEL-101 in AL Amylo...

                            Details : An e-poster featuring the first data from a new arm of the study demonstrated that CAEL-101 administered in combination with cyclophosphamide-bortezomib-dexamethasone (CyBorD) plus daratumumab was generally safe and well-tolerated in the first four weeks...

                            Brand Name : CAEL-101

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            June 11, 2021

                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Alexion Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            Caelum Biosciences

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                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase III

                            Sponsor : Alexion Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Caelum and Alexion Announce Upcoming Data Presentations at the 62nd American Society of Hematology Annual Meet...

                            Details : Accepted abstracts include Phase 2 safety, efficacy, and tolerability data for CAEL-101 in AL amyloidosis. Data, from Caelum, that further shows safety and tolerability of CAEL-101 and support the selection of the 1000 mg/m2 dose for the Phase 3 study wi...

                            Brand Name : CAEL-101

                            Molecule Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 04, 2020

                            Lead Product(s) : CAEL-101,Cyclophosphamide,Bortezomib

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase III

                            Sponsor : Alexion Pharmaceuticals

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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